Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
Dendritic arbors provide neuroscience with an ideal opportunity to study how individual neurons interact with their broader circuitry and are the field’s best bet to bridge cellular and systems neuroscience, writes @justinkohare.bsky.social.
#neuroskyence
www.thetransmitter.org/dendrites/de...
I spoke with Laura Schenkman at The Transmitter about my candidacy for the House!
Going from the lab to public life is a huge transition. From a lifetime of research to biotech to democracy to running for office, here’s the story of one scientist: www.thetransmitter.org/policy/is-th...
A brief trip to visit the Weizmann Institute and Hebrew University of Jerusalem.
The students left a big impression - some of most engaging trainees I've met. They care a lot about the science. I hope they enjoyed the exchange of ideas as much as I did.
PS - hummus! We had hummus every meal.
Spiking of head-direction cells in the postsubiculum during movement (top) and during the transition from non-REM to REM sleep (bottom). Cells are sorted and colour-coded according to their preferred directions.
I don't think I'll ever get bored of looking at raster plots of head-direction cells 🤩
Yikes. Even if so, and that happened recently to us, they should issue a publishers correction 🤦♂️
This 👇is the last revolution. We are working on the next one - and need your help.
HIRING: Postdoc at NYU (Center for Psychedelic Medicine). Looking for strong neuroimaging, human subjects experience, a publication track record, and top scientistiness.
Send CV to joshua.siegel@nyulangone.org
Seems risky to start with a receptor specific agonist with unclear clinical relevance 🤷♂️
That’s why we go with receptor knockouts..
Different approach - top-down or bottom-up?
Regarding point 8, it is a confound if the goal is to hone in on 5-HT2A agonism.
Usually we are interested in the drug itself, where as you show - polypharmacology is part of the deal. That is the whole package and the totality of the effects is what we want to measure in the brain.
Our paper with @vyazovskiy.bsky.social showcasing research conducted at @ox.ac.uk @oxforddpag.bsky.social is out!
We describe the effects of the psychedelic 5-MeO-DMT on brain states and sleep via EEG, LFP & freely moving oculometry.
Read more: www.nature.com/articles/s42...
#EEG #neuroskyence
Science 4 building at Binghamton University.
A quick trip down the road to visit Binghamton University today.
First thing I saw was these giant brain prints on the windows. 🧠😀
News from central Jersey: I'm running to represent New Jersey's 12th Congressional District.
By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come!
samwang.substack.com/p/entering-t...
BG GRC Oath: I acknowledge that the go/no-go model of the BG was useful but it is outdated and incorrect, or at least incomplete. I pledge not to use the go/no-go model as a strawman to motivate my work.
Taking the #GRCBasalGanglia Oath ✋🏼
I acknowledge that the go/no-go model of the BG was useful but it is outdated and incorrect, or at least incomplete. I pledge not to use the go/no-go model as a strawman to motivate my work.
Not sure where your pACC sits relative to our coordinates though. The region we targeted for tracing may be more anterior.
We saw a fair amount of input cells in AId and AIv with monosynaptic rabies tracing from ACAd in the recent paper.
Those inputs where notably modified after drug administration.
pubmed.ncbi.nlm.nih.gov/41352354/
🙏🙏🙏
Thanks it is definitely giving us some experiments to try!
Are there variants of these models that include interneuron subtypes?
We may have some data to evaluate the variability aspect of your hypothesis - e.g., signal and noise correlation measurements.
Top-down and button-up inputs can be strictly defined in a model, but it may not be so clear cut in the brain to be testable. Though the idea is certainty enticing.
Important to developing stronger models to understand psychedelic's effects!
It was particularly surprising for me to see that plasticity was elevated at intermediate alpha, given the gating scheme in the architecture. Your explanation makes sense.
cc @tyrellturing.bsky.social
A line grant showing new and competitive renewal awards made by NIH is fiscal year 2026 compared to 2021-2025. The line for fiscal year 2026 is very close to zero.
My (now) weekly update on 2026 NIH funding.
New and competitive renewal awards.
3 new awards (compared to ~100 expected based on recent years).
No new ICs... still just NIA, NINDS, NIDCD, and NIDCR.
1/2
Our paper on the "Oneirogen hypothesis" is now up in its revised form on eLife!
This is the hypothesis that psychedelics induce a dream-like state, which we show via modelling could explain a variety of perceptual and learning effects from such drugs.
elifesciences.org/reviewed-pre...
🧠📈 🧪
Hammock at the beach.
Still working and catching up on emails, but this will be my office today 🇧🇸 #ACNP2026
Important message from Nev Jones to sr people in the field:
Don’t treat young emerging researchers w/ lived experience as a checkbox. Asking them for a grant letter solely because of lived experience puts them in a difficult-to-impossible bind due to power dynamics @acnporg.bsky.social #ACNP2026
Congratulations!!
Can humans & animals really use internal maps to take shortcuts?
Tolman famously said yes - based largely on his Sunburst maze.
Our new review & meta-analysis suggests evidence is far weaker than you might think.
🧵👇 doi.org/10.1111/ejn....
@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social
Been waiting for such a study to relate #psilocybin dose to 5-HT2AR occupancy in the mouse brain.
They found RO₅₀ = 0.88 mg/kg.
journals.sagepub.com/doi/10.1177/...
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
Thanks for sharing this. Trying to learn more about networks delineated by neuroimaging since our last study, and this video is the clearest explanation yet. 👍
Number of BME faculty job opening is noticeably down this year.
We just had this question at a faculty meeting and @pratted.bsky.social has the visualization for the answer.
