How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ?
Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...
Hey Chromatin Friends!
Long time no chromatin question...
For many of you, CUT&x (RUN/Tag) works really well but some of you have had their frustrations with CUT and "gone back" to ChIP-Seq. Can you share your experiences in the comments!?
Would love to hear from you!
Sharing is appreciated : )
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
Structural basis for non-AUG translation regulation by 5MPs https://www.biorxiv.org/content/10.64898/2025.12.28.696766v1
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
Its out!!!
IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
It has not escaped our notice that LLM generate replaceable, non-intuitive statements suggesting a mechanism of dullness and copy paste
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
General framework for centromere organisation built on a model of the internal stratification of the Earth
Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
There are two big traps that US higher education fell into.
First: the research building boom. Universities realized that by constructing new research buildings, they could raise their indirect cost rate, the percentage of federal grant money that they can claim for overhead.
2/10
I don’t think most people (including academics) realize just how screwed American universities are right now. Yes, the Trump attacks hurt. But the deeper crisis comes from the slow rot of a corporate mindset in university leadership that traded mission for growth. Let’s talk about that.
A 🧵
1/10
Leider wahr. #DenkIchAnDeutschland
gersemann.substack.com/p/2-how-germ...
UMass Chan Medical School has received a five-year, $4.4M grant to study how transfer RNAs may drive the spread of melanoma: direc.to/nJeJ
Richard I. Gregory, PhD, is collaborating with Beth Israel Deaconess Medical Center and Brown University.
#CancerResearch #melanoma @bidmcreseach.bsky.social
Many thanks to all attendees of the GfG Sympsoium "Epigenetics & Chromatin" for making this conference such a great success! Go to www.gfgenetik.de for more information and fotos. Become a GfG member!
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Bäm
Please never show this to my mom!
I love the smell of toxische Abgase in the morning
I too have never seen star activity in EcoRI digests.
Öffentliche Briefwahl
Guter Kandidat für Porno pingpong
Endlich sagt’s mal einer!
Hoodie statt Hemd. Stabil.🤘
