cosy home office time 🐱
12.12.2025 20:31
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cosy home office time 🐱
No, James Watson was not a "complicated" person. He was a bad person, and also a bad scientist. These racist, sexist statements, his sincere beliefs, are both morally indefensible and scientifically absurd. With every year that passes, let his name fade and Rosalind Franklin's shine the brighter.
today was my last day in the group — will miss my small mathematikon family so so much! 💗
ah, and I also submitted my dissertation ✨
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🔗 check the preprint for more details!
www.medrxiv.org/content/10.1...
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🙏 a special thanks to @abigailsuwala.bsky.social, @moritzgerstung.bsky.social, and Felix Sahm for their exceptional guidance and mentorship throughout this project. and heartfelt thanks to all our co-authors for valuable contributions and discussions!
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💭 together, these results highlight how tumour–immune cell interactions shape radiation-induced brain changes, distinct from true progression.
our work provides a molecular foundation to improve diagnostics and treatment in GB patients.
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in RN:
🔍 high numbers of tumour cells with low EGFR expression and no proliferation despite EGFR amplification.
🔍 the tumour cells colocalised with infiltrating border-associated macrophages releasing cytokines, likely contributing to gliosis.
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🧠 our key findings:
in recurrent GB, we found progenitor and proliferating tumour cells with high EGFR expression.
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🎨 we built a spatially resolved single cell atlas of ~1,19M cells encompassing nine cell types –– the first of its kind directly comparing histologically confirmed RN changes and recurrence in GB.
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🔦 we analysed 10 samples from 9 GB patients who all showed radiological progression. however, histopathology revealed:
🧠 4 true recurrences
🔬 4 RN changes
🖇️ 1 mixed case
we profiled these with 10x Xenium and the Brain Expression Panel.
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💡 why this matters?
radiotherapy is standard treatment for GB, but it can cause RN changes that mimic tumour progression on MRI and cause similar symptoms – yet require very different management. hence, histopathology remains the diagnostic gold standard.
🚨 new glioblastoma preprint alert!
we present the first spatially resolved single cell atlas comparing radionecrotic changes (RN) and recurrent IDH-wildtype glioblastoma (GB) –– shedding light on a long-standing diagnostic challenge.
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