Mara Sherman

Congratulations!! Amazing team and inspiring story! ✨

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.

Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social

www.nature.com/articles/s41...

AMEN SISTER 🩵

We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—

Heads up to any pancreatic cancer research that either had their R01 yanked or missed funding due to the newly restrictive paylines in 2025 (specifically anyone who scored 15%ile or below, but didn't get funding). media.pancan.org/rsa/2026/Pan...

Thrilled to share our new paper published in Cancer Research (@theaacr.bsky.social), led by outstanding work from Priyanka Gupta in our lab. Our study uncovers how stromal aging fundamentally reshapes pancreatic ductal adenocarcinoma (PDAC) biology. aacrjournals.org/cancerres/ar...

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Submit an abstract by October 1 for the AACR Special Conference on Cancer Evolution (December 4-6; Albuquerque), chaired by Mariam Jamal-Hanjani, Kenneth J. Pienta, and Mara H. Sherman and held in association with #AACRCEWG.
buff.ly/meDBvm2
#AACRevol25 @marasherman.bsky.social

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...

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Gerstner Sloan Kettering Graduate School of Biomedical Sciences The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1

How can we reawaken the body’s own anti-viral defenses to fight brain cancer?

Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏

#BrainTIME 🧠🦠🧪
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www.sciencedirect.com/science/arti...

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer PI5P4Kα is a critical metabolic gatekeeper in PDAC, promoting glucose and iron acquisition to support tumor survival. Arora et al. demonstrate that PI5P4Kα suppression disrupts the metabolic flexibili...

Thrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Mechanical confinement governs phenotypic plasticity in melanoma - Nature Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

Mechanical confinement governs phenotypic plasticity in melanoma

www.nature.com/articles/s41...

To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨

Where we’re going, we don’t need paylines. 😳🙈

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...

www.nature.com/articles/s41...

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunit

the treasure trove of all sequencing datasets

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...

Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

Alright! Took me way too long but I’m here and trying to re-engage. The world is burning but the #BAPlab is not! Up next! In two weeks our lab twins Garima Baral and Clair Pfeffer will defend their Ph.D.s 🔬I may burst from excitement or stress, one of the two. @cancer-inst-purdue.bsky.social

“America First” Will Destroy U.S. Science The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨

BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our u...

I am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer.

www.biorxiv.org/content/10.1...

Registration is OPEN for the next edition of The Tumour Ecosystem! 🎉

Taking place next March in Bergamo, this conference will cover the latest advances in research of the tumour microenvironment.

Learn more and register now: eacr.org/conference/t...

Thank you my queen!! 💜💜 Inspired by you and other leaders, we are so keen to learn more about tissue-level tumor suppression alongside our amazing pancreatic cancer research community ✨

Check out this seminal study @theaacr.bsky.social by the one and only @marasherman.bsky.social

aacrjournals.org/cancerdiscov...

& the commentary about its importance to gain understanding on the inherent tumor-suppressive #PancreaticCancer #TME (by yours truly)

aacrjournals.org/cancerdiscov...

Last night, past Mark Foundation Emerging Leader Award winners gathered with this year’s recipients, @marasherman.bsky.social , @liron1bar-peled.bsky.social, Kai Kessenbrock, Ansu Satpathy, and Dan Wahl, to celebrate seven years of this transformational program. #MarkSymposium

Wowww! Congratulations to the unstoppable Bar-Peled lab! 🥳