So exciting!!

Restoration of pancreatic beta cell identity and autophagy in KATP-induced diabetes by intermittent fasting - Diabetologia Aims/hypothesis The loss of pancreatic beta cell mass and identity is a hallmark of diabetes. While factors such as beta cell overwork (insulin hypersecretion) and elevated intracellular calcium have been implicated, beta cell identity loss also occurs in KATP gain-of-function (KATP-GOF) mice, a model of human neonatal diabetes, even in the absence of these factors. This suggests additional underlying mechanisms. Autophagy, a key process for cellular homeostasis, is impaired in the islets and beta cells of both type 1 and type 2 diabetes, but its role in monogenic diabetes with insulin secretory deficiency remains unclear. We hypothesise that autophagy dysfunction contributes to beta cell identity loss in KATP-GOF mice, and that intermittent fasting (IF) can restore autophagic flux, thereby preserving functional beta cell mass. Methods To test this, adult tamoxifen-inducible KATP-GOF mice and littermate controls were randomly assigned to two groups: (1) chow diet ad libitum; and (2) chow diet with alternate-day IF. Results KATP-GOF mice fed ad libitum developed severe hyperglycaemia due to impaired insulin secretion. This was followed by a reduction in insulin content, disruption of beta cell autophagic flux, autophagosome accumulation and, ultimately, the loss of beta cell identity and dedifferentiation. In contrast, KATP-GOF mice subjected to alternate-day IF exhibited lower blood glucose levels, improved mitochondrial morphology, restoration of autophagic flux and reestablishment of beta cell identity. Conclusions/interpretation This study provides the first evidence of autophagy impairment in non-obese, insulin secretory-deficient, KATP-induced diabetes mice and demonstrates that IF restores both autophagic flux and beta cell identity. This finding suggests that similar mechanisms may contribute to beta cell dysfunction in other forms of diabetes. Graphical Abstract

Based on studies of autophagy in non-obese, insulin secretory-deficient KATP-GOF mice the authors propose that #IntermittentFasting prevents the gradual loss of beta cell identity by enhancing autophagy link.springer.com/article/10.1...

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A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...

Thank you!

Thank you Peter!

Thank you!

Thank you Scott!

Thanks so much!

Thank you!!

I'm very excited to share that I'll be starting as an Assistant Professor at the University of Alberta this fall 🎉 !!

I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️.

www.ualberta.ca/en/physiolog...

An illustration of a woman with a trail of papers behind her. The hedline is: How I finally found my confidence as a scientist

"Many scientists know from the start that they want to be academic researchers. But for others the path unfolds gradually, with spurts of doubt and uncertainty along the way. In a way, that’s fitting." #ScienceWorkingLife scim.ag/43Ph9Ei

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