Jiarui Mi

nice overview of the mechanisms of beta cell regeneration! Big congrats!!!

Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se

Congrats, Sumeet! Didn't know you move back to India. Hope you enjoy your new scientific research in the new place! And very welcome if you have time to visit China.

Benchmarking porcine pancreatic ductal organoids for drug screening applications Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

Blueprints of Life: Cell fate choices and lineages Dive into the fascinating world of cell fate decisions that underlie the variety of cell types in our bodies. Join top researchers in the field to uncover the blueprints of life!

A great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social
To register 👇

news.ki.se/calendar/blu...

We offer three new positions to join BCA Phase 0:
1. A full-stack developer to work on the BCA database with @ebi.embl.org
2. A senior research technician to develop sc methods
3. A bioinformatician to analyze new atlases with @sangerinstitute.bsky.social

Details below.

Please, share and repost.

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Big Congrats, Christos! Finally out. BTW, do you have any sensors candidates that you would like to work with? Have a look at this webpage: pharmacy.ecust.edu.cn/zyz/list.htm

Very nice summary!

Cool!

Such a cool paper!! #PancSky

I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!

bsky.app/profile/did:...

Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
www.science.org/doi/full/10....

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓)
We decided to call them TIGR-Tas systems 🐯

How Does the Gut Immune System Distinguish Between Friends and Foes? Cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

Rockefeller's @cicacanesso.bsky.social talks to The Scientist about her recent work with @danmucida.bsky.social and @victora.bsky.social on how cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

Mapping cells through time and space with moscot - Nature Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Lineage tracing of pancreatic cells for mechanistic and therapeutic insights Recent advances in lineage-tracing technologies have significantly improved our understanding of pancreatic cell biology, particularly in elucidating the ontogeny and regenerative capacity of pancreat...

Lineage tracing of pancreatic cells for mechanistic and therapeutic insights: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions o...

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis.
www.science.org/doi/10.1126/...

👍👍 thank you for the fabulous team work!

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...

Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)