👀👀 @ilc6.bsky.social
#excited
01.06.2025 12:37
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👀👀 @ilc6.bsky.social
#excited
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
Welcome to bluesky Sarah! Rod Rahimi assembled several immunology starter packs in case you’d like to connect with them :)
bsky.app/profile/rodr...
#immunosky
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!
www.nature.com/articles/d41...
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...
#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
Should we “normalise” the gut myco(& micro)biome across facilities to increase reproducibility? What is normal?
The authors further showed that mice from JAX lab (where many of us get lab mice from) lack this commensal. Differences in mycobiome can dramatically influence immunity.
In @nature, Liao et al showed this commensal promotes type-2 immunity in the gut via IL-33/ST2, influencing protective anti-helminth responses and food allergy models.
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.
www.nature.com/articles/s41...
Happy to answer any specific questions you may have and/or share my experience either here or privately :)
We used BD Cytofix/perm, Foxp3 fix/perm or 2% PFA fixation and these were all compatible with 2W1S tetramer staining and downstream cytokine analyses by flow
I can still see some after stimulation, so it’s not like the stimulation will completely negate tetramer staining (at least for 2W1S-MHCII tetramers). Worth a try!
Agree with the above and I will add that at least for class 2 tetramers, it will depend on the specific tetramers that you use. Unfortunately a lot of the class 2 tetramers are not great compared to class 1, and in my experience both the MFI and % positives may reduce after stimulation, but
🚨🚨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM 🏳️🌈🏳️⚧️🧪 #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Yesss!!!
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
Can I be added please :)
Some of us already hallucinate more than others and we definitely don’t need more of that
Hyaluronan and collagen III expression in allergic lung
New Slains castle at Cruden Bay
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
#immunosky
B cell and TFH researchers:
Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...
go.bsky.app/Eaua5Jk my starter for neuroimmunology
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.
go.bsky.app/AjNpW2h
