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Julian Sale

@juliansalelab

Group Leader, MRC Laboratory of Molecular Biology & Joint Head of the Division of Protein & Nucleic Acid Chemistry. Senior Executive Editor, Nucleic Acids Research.

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23.11.2025
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Latest posts by Julian Sale @juliansalelab

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

25.02.2026 22:25 πŸ‘ 51 πŸ” 54 πŸ’¬ 1 πŸ“Œ 0
Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

24.02.2026 09:45 πŸ‘ 36 πŸ” 48 πŸ’¬ 0 πŸ“Œ 2
Preview
Molecular Techniques Training Seminars 2025-26 - YouTube The recordings are from the LMB's recent series of training seminars 'Biophysical Techniques Course: Solving Probes with Molecular Techniques.'Featuring expe...

Interested in all the molecular techniques available at the LMB to help researchers?
Check out this lecture series on our Youtube channel: www.youtube.com/playlist?lis... πŸ§ͺ

17.02.2026 15:33 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. πŸ₯³

mrc.tal.net/vx/mobile-0/...

16.02.2026 12:09 πŸ‘ 83 πŸ” 106 πŸ’¬ 1 πŸ“Œ 2

A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.

12.02.2026 22:52 πŸ‘ 18 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

Or as the doi is not yet active ... www.biorxiv.org/content/10.6...

12.02.2026 21:41 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Just posted our latest, led by Consuelo Perez and Pierre Murat, showing the intimate relationship between transcription, DNA supercoiling and chromatin architecture during human stem cell differentiation. Thanks to all at @mrclmb.bsky.social doi.org/10.64898/202...

12.02.2026 21:35 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Required reading for everyone interested in the synthetic genomics - @adrianwoolfson.bsky.social's new book 'On the Future of Species' is published today (Charles Darwin's birthday). Here's the man himself at the launch last night at @dauntbooks.bsky.social in Marylebone. (Photo: Wes Robertson)

12.02.2026 09:38 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..

A few points and new information that bioscientists may find interesting...

A 🧡

03.02.2026 13:57 πŸ‘ 51 πŸ” 50 πŸ’¬ 1 πŸ“Œ 3

Ever worried that your redesigned genome might not replicate as expected? Well, help is at hand with a genome language model for replication origins from the Boemo lab (with a little bit of help with some new data from us). www.biorxiv.org/content/10.6...

02.02.2026 21:34 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Suyang Zhang smiles in front of a blurred laboratory background

Suyang Zhang smiles in front of a blurred laboratory background

Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs

27.01.2026 09:40 πŸ‘ 5 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

Deeply saddened by the sudden death of David Abulafia at the weekend. A brilliant historian of the Mediterranean and a Fellow of @caiuscollege.bsky.social for over 51 years. We will miss him enormously.

26.01.2026 09:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Our beloved and long-serving @mrclmb.bsky.social PNAC Divisional Administrator Michele Hare has retired. We gathered to wish her well and a long, happy and music-filled retirement.

23.01.2026 18:42 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...

Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...

23.01.2026 06:57 πŸ‘ 51 πŸ” 15 πŸ’¬ 2 πŸ“Œ 2
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Tree Court @caiuscollege.bsky.social without, err, its trees. Sad but it provides a marvellous architectural vista from 15th - 19th century

20.01.2026 09:12 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
The organ of St John's Chichester played by Margaret Phillips.
The organ of St John's Chichester played by Margaret Phillips. YouTube video by Historic Organ Sound Archive

Christmas Holiday project - completed the mixing & edits of Margaret Phillips’ recital on the G.P. England organ in St. John’s, Chichester for the Historic Organ Sound Archive. Transport yourself back with the sounds of a wonderful Georgian instrument and the music of the time.

07.01.2026 22:47 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

We have an opening for a research support officer. Come and join us! Please share.

22.12.2025 12:09 πŸ‘ 17 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0

Quite … have a just a little mercy on your editors and reviewers! πŸ˜ŠπŸŽ„

21.12.2025 12:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Jesus College Cambridge, 'Sutton' organ played by Benjamin Sheen.
Jesus College Cambridge, 'Sutton' organ played by Benjamin Sheen. YouTube video by Historic Organ Sound Archive

Our latest offering from the British Institute of Organ Studies Historic Organ Sound Archive in which you can hear Ben Sheen exploring the delights and outer reaches of fifth-comma meantone tuning in pieces by John Bull and Michelangelo Rossi among others. www.youtube.com/watch?v=XfvQ...

14.12.2025 21:46 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. πŸ₯³

10.12.2025 22:08 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
How to Buildβ€―Aβ€―Synthetic Human Chromosome - Science Museum Blog Roger Highfield, Science Director, describesβ€―the first real stride toward writing human genomes from scratch.

A great explainer from @rogerhighfield.bsky.social on the first step towards building human genomes, published in @science.org today. #SynHG blog.sciencemuseum.org.uk/how-to-build...

04.12.2025 19:39 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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High-fidelity human chromosome transfer and elimination The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

04.12.2025 19:27 πŸ‘ 28 πŸ” 10 πŸ’¬ 0 πŸ“Œ 1
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Another one bites the dust Science of The Total Environment has been delisted by Web of Science. Scientific Reports is set to publish 45,000 articles this year, likely generating over $100 million in revenue. Could it be next?

"Scientific Reports likely to generate >$100M this year...When a journal publishes 45K articles...some bad papers will be published. The big unknown is whether [the now infamous β€œFactor Fexcetorn” paper] is the visible tip of a research integrity iceberg" newsletter.journalology.com/p/another-on...

03.12.2025 13:32 πŸ‘ 11 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1
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Congratulations Dr.Zeller! Thanks to @niakanlab.bsky.social and Prof Doug Higgs for giving him a good grilling.

03.12.2025 17:43 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

After deleting the lab Twitter/X account last year, here we are at last on Bluesky. Some exciting things to come, and some occasional bits and pieces that are just generally fun and interesting (to me at least).

27.11.2025 19:43 πŸ‘ 33 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0