SellinLab

It’s finally here! 🎉
Delayed a bit by the classic post-PhD lab change, but very happy to see this work published. Thank you @lionelguy.bsky.social and @sellinlab.bsky.social 😄

Most updates from our lab nowadays found at LinkedIn:

www.linkedin.com/in/mikael-se...

The pcnB gene sustains Shigella flexneri virulence Author summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...

Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen...

In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.

Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården.

#Organoid #UppsalaUniversitet #Forskning

@eurjimmunol.bsky.social

With key contributions from Grisna Isabel Prensa and Julia Andersson, and made possible through our long-standing collaboration with the Pejler laboratory.

Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria Mast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-sec....

Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek.

onlinelibrary.wiley.com/doi/10.1002/...

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization - npj Vaccines npj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines

www.nature.com/articles/s41...

Microbial Pathogenesis & Host Response Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo.

i3scongress.innozh.fr

Congrats, @alexandraboegli.bsky.social !

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

📢ONLINE @natgenet.nature.com

📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.

By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.

⬇️

www.nature.com/articles/s41...

@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.

Poster of Understanding and predicting microbial evolutionary dynamics 2025 saying that abstracts are closing. With the date of the event and location.

The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25

New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.

#Shigella #virulence #microsky

Organoid models advance dysentery control - Nature Genetics Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...

Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday.

www.nature.com/articles/s41...

Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com.

Link to the full paper here: rdcu.be/eqGgf

The study would not have been possible without the relentless drive of @mldm.bsky.social and the very fruitful collaboration with Laura Jenniches and @lbarquist.bsky.social at the @helmholtz-hiri.bsky.social and many other colleagues. @andrenmateus.bsky.social, @erixoneriksson.bsky.social

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.

Out @natgenet.nature.com:

rdcu.be/eqGgf

I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.

New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...

Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......

Changes to the 2026 and 2027 Work Programmes With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Planning to apply for #research #funding from the ERC?

From the next application rounds, expect changes to the:

• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)

More 👇 europa.eu/!RPHWvv

With relevance also to epithelial #glycocalyx biology and #inflammasome signalling.

Kudos to first lead author Petra Geiser, and to all the contributors @uu.se, @scilifelab.se, Uppsala university hospital, @mldm.bsky.social @erixoneriksson.bsky.social

The study highlights how just a handful of differing virulence factors active at the epithelial surface invasion step (Salmonella) vs at the intraepithelial expansion step (Shigella) to a large extent can explain the contrasting epithelial infection cycles of these related bacteria.

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio Pathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. This work combines ba...

Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.

journals.asm.org/doi/10.1128/...

The LeibundGut-lab at the @mrccmm.bsky.social, in collaboration with @neil-gow.bsky.social, recruits two postdocs to study the skin commensal yeast Malassezia in atopic dermatitis #fungalrecognition and #fungalimmunology jobs.exeter.ac.uk/hrpr_webrecr... jobs.exeter.ac.uk/hrpr_webrecr...

Great meeting coming up next May
www.keystonesymposia.org/conferences/...

#EESInfection was very inspiring and enriching! Thanks for all new connections and for the opportunity to present our soon to be published story on TraDIShigella during infection of human intestinal organoids! Stay tuned to read the full story!