@markusmukenhirn
Post-Doc @katjaroeper.bsky.social lab @pdncambridge.bsky.social Interested in kidney organoids and lumen formation; Former @honigmann_lab, @biotec-tud.bsky.social, @cmcb-tud.bsky.social,@mpicbg.bsky.social and @boulantlab
Apply now for the Signaling by Adhesion Receptors GRC June 7 - 12, 2026! The meeting has a terrific program that balances developmental biology, cell polarity, and adhesion and signaling. Please share!
www.grc.org/signaling-by...
Our new review on epithelial barrier homeostasis has been published in Trends in Cell Biology(www.cell.com/trends/cell-...)! Please use the following link for free access until May 1: authors.elsevier.com/a/1mlnq3QxxT...
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
On my way! I will talk in and chair the first session Thai afternoon, make sure to be there! #gfe2026
Hat zufällig jemand den #Meteor #Feuerball gegen 19 Uhr gesehen oder sogar fotografiert/gefilmt oder mag etwas zu der Beobachtung erzählen für einen Artikel bei fr.de/merkur.de? #Followerpower
Two complementary articles from the lab of Anming Meng and Katie McDole discussing the history and biology of organizer in 🐟, 🐸, and 🐭. Even after more than 100 years since its discovery, major questions remain, especially for mammals.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
🚨 New paper from our lab just published in Nature🚨
www.nature.com/articles/s41...
Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone
✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social
New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...
Riedel, L., Wössner, V., Kempf, D., Ziebert, F., Bastian, P., & Schwarz, U. S. (2025). The positioning of stress fibers in contractile cells minimizes internal mechanical stress. Journal of the Mechanics and Physics of Solids, 195, 105950. #EpithelialMechanics
www.sciencedirect.com/science/arti...
🚨 New Preprint from the Paluch & Chalut Labs 🚨
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...
Yang, H., Meyer, F., Huang, S., Yang, L., Lungu, C., Olayioye, M. A., Buehler, M. J., & Guo, M. (2024). Learning collective cell migratory dynamics from a static snapshot with graph neural networks. PRX Life 2, 043010. #EpithelialMechanics
doi.org/10.1103/PRXL...
"Here, we present SPAtial Cell Exploration (SPACE), a spatial CRISPR screening platform that integrates whole-transcriptome profiling (~18,000 genes), multiplexed protein detection (~68 markers), and CRISPR perturbation mapping at subcellular resolution"
www.biorxiv.org/content/10.1...
Word!
• Figure 1 of the article: Fig. 1. Phase diagram of tissue material phase transitions and examples. (A) Schematic diagram showing how continuous changes in microscopic dynamics (control parameter) lead to abrupt, drastic, and non-linear shifts in macroscopic properties that define the material response (order parameter). (Aa-Ab) Exemplary phase transitions as traditionally described in non-living matter, e.g. for water (Aa), as well as in living matter, e.g. for embryonic tissues (Ab). Yellow areas indicate fluid-like tissues and regimes. Blue areas indicate solid-like tissues and regimes. Magenta dashed line depicts the critical point. Orange line marks particle and cell trajectories.
Tissue phase transitions in development: more than just mechanics
In this Review, @nicolettapetridou.bsky.social, @laura-rustarazo.bsky.social and @karengrace12.bsky.social discuss tissue phase transitions during development: doi.org/10.1242/dev....
Congratulations 🎉
Delighted to see my PhD work finally published! Here we used the amazingly versatile Drosophila model system to uncover mechanisms behind the rare renal disorder Dent's disease. Have a read over at: www.kidney-international.org/article/S008...
Just back from the annual meeting of the @dfg.de priority program #SPP2332 on "Physics of Parasitism", this time at the Robert Koch Institute at Berlin. So many great talks and discussions! Already looking forward to next year's meeting at Hamburg👍
Happy to share this work from Carlos Camacho de la Maccora that reveals how rates of posterior progenitor addition and anterior vacuolation are balanced across the notochord. With Alberto Ceccarelli and @osvaldo-chara.bsky.social we present a model of long-range communication to provide robustness.
New work from our group now online @biorxiv-devbio.bsky.social 🤩
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
On my way to Basel, where I'll talk about "Mechanics of lumina" @biozentrum.unibas.ch tomorrow. Surprisingly, my 6-minute train connection at Fulda worked out.
Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines.
So, @science.org story is here and 🧪🧵 is coming:
www.science.org/content/arti...
5/ Marthe Gautier played a crucial role in identifying trisomy 21 as the cause of Down syndrome.
Working with minimal institutional support, she built a cytogenetics laboratory from scratch and produced the preparations that revealed an extra chromosome in affected children.
4/ Ida Henrietta Hyde developed one of the first intracellular microelectrodes for stimulating and recording single cells. She opened new ways of studying nervous and circulatory systems, and became the first woman to receive a PhD in physiology from the University of Heidelberg.
3/ As a PhD student, Hilde Pröscholdt Mangold carried out the embryo transplantation experiments that demonstrated the organiser effect in newts. She performed more than 250 transplants, with only a handful surviving to provide the results that shaped the field.
2/ Ethel Browne Harvey’s experiments on hydra helped establish a key idea in developmental biology: that certain tissues can organise the development of an entire body plan.
In 1909, she showed that grafting tissue from the mouth region could induce a second body axis.
UNESCO international day of women and girls in science. celebrating four largely overlooked pioneers in science
1/ Today is UNESCO’s International Day of Women and Girls in Science #IDWGIS
To mark the occasion, Lisa Thomann and Julie Batut highlight four pioneering biologists whose work shaped developmental biology, electrophysiology, and genetics.
🔗 buff.ly/eVipb6d
Join for our exciting meeting in Spain!
Deadline for abstracts today!
Figure from: Hypoxic injury triggers maladaptive repair in human kidney organoids
Kidney organoids exposed to low oxygen recapitulate key features of acute kidney injury and maladaptive repair. Multi-omic profiling reveals conserved inflammatory, metabolic, and injury signatures matching human disease.
https://www.biorxiv.org/content/10.1101/2023.10.04.558359
