Konstantin Benno Bräutigam

Truly amazing

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Excited to share our (slightly opinionated 🤯) review piece on AI-led CRC reporting in "The Journal of Pathology"

Thanks to @trevorgraham.bsky.social for supervision and inspiration!

pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...

That's cool

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Fantastatic paper from my host lab looking at the immune-genome intersection in the "big bang" of #CRC!

Macrovascular tumor infiltration and circulating tumor cell cluster dynamics in patients with cancer approaching the end of life - Nature Medicine This prospective cohort study of patients with cancer incorporated antemortem follow-up visits and rapid autopsy analyses, and reports that spikes—rapidly increasing levels—of circulating tumor cell c...

Interesting findings on circulating tumour cell peaks and vessel occlusion in "hot autopsies"
www.nature.com/articles/s41...

#ESSB2025

ESSB Working Group survey Please enter your information to join an ESSB working group

Happy to co-chair the #Pathology Working Group of the European Society for Spatial Biology (ESSB) e.V. #ESSB with Francesca Maria Bosisio, MD, PhD and Christian Matek, MD!

Please join the group and let us promote science together!

Link to join: docs.google.com/forms/d/e/1F...

Thanks for sharing! 🫶

Great to see some exciting applications of #MuSpAn in action in @pathologop.bsky.social's talk at #ESSB2025 today!

Come and say hi if you'd like to find out more about the software, or to have a chat about how MuSpAn might be able to help with your data analysis :) #EMBLSpatialBiology

Cheers @joshuabull.bsky.social and @joshmoore.bsky.social, great toolbox!

CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer).

Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).

Read this here: www.biorxiv.org/content/10.1...

Spatial architecture of development and disease - Nature Reviews Genetics Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.

The #spatial architecture of disease

www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Communication in pathology, the power of word. Excellent keynote at #ecp2025 in #vienna!

So accurate, it hurts

Pathobiology — Can We Do Without It? | NEJM With changes to preclinical curricula, some medical schools have eliminated certain freestanding subject-based courses, such as histology and pathobiology.

www.nejm.org/doi/full/10....

😂

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

www.nature.com/articles/s41...

Happy to share our preprint on #pancreatic #cancer using a combined #digitalpathology #ish #ihc approach!

www.researchsquare.com/article/rs-6...

Fantastic workshop on the ecology and #evolution of cancer #EBEC2025! So thrilled and proud to have been part of it! @sangerinstitute.bsky.social #cambridge

Looking forward to the "Evolutionary Biology and Ecology of Cancer" course in #Cambridge at the #wellcome genome campus! #genomics

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy

Published @natcancer.nature.com

Melissa is an outstanding new clinician scientist.. one to watch.

www.nature.com/articles/s43...

@icr.ac.uk

Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer Epigenetic alterations co-evolve with genetic mutations to drive carcinogenesis and treatment response. Resolving genome-epigenome coevolution requires accurate multi-omic single cell measurement. Her...

dATAC: our new method for simultaneous very high quality whole genome sequencing and chromatin accessibility profiling of single cells. We used dATAC to trace epigenome clonal evolution in colon cancer. Devised by the extraordinarily talented @maxmossner.bsky.social

www.biorxiv.org/content/10.1...

Evolutionary paths towards metastasis - Nature Reviews Cancer In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insigh...

www.nature.com/articles/s41...

I enjoyed the read!

Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma revisited - Exploring the “Space” Pancreatic ductal adenocarcinoma (PDAC) remains one of the most deadly malignancies with a highly immunosuppressive tumor immune microenvironment (TIM…

Pancreatic cancer and its spatial TIME: Lots to learn and to do!

www.sciencedirect.com/science/arti...

#pathsky
Excellent talk on pancreatic neuroendocrine neoplasms at the Spring Meeting of the Austrian Society for Pathology y Konstantin Bräutigam @pathologop.bsky.social #oegpath

Thank you for inviting! Great meeting!