Reid Alderson

Stories from the scientist who changed how we visualize proteins - Nature Reviews Chemistry Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D stru...

this was published this week, in case you haven’t seen it: www.nature.com/articles/s41...

EMBO Practical Course: Structural dynamics, interactions & function of biological macromolecules by NMR

EMBO Practical Course: Structural dynamics, interactions & function of biological macromolecules by NMR @embo.org
📅 July 24–31, 2026
📍 BNMRZ, Technical University of Munich (Garching)
📝 Registration open | Deadline: Apr 17, 2026
🔗 embo2026.bnmrz.org

#NMR #StructuralBiology #EMBO #NMRchat 🧲

A dynamic displacement mechanism drives protein import into mitochondria Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...

📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8

EMBO @embo.org Practical Course, Structural dynamics, interactions and function of biological macromolecules by NMR, July 24-31, 2026, Bayerisches NMR-Zentrum (BNMRZ) Technical University of Munich, Garching
embo2026.bnmrz.org Application & registration will open in January #NMRchat 🧲

AIP Structural Dynamics, request for submissions, Special Issue, Tribute to a Lifelong Innovator: Prof John Markley @nmrfam.bsky.social and the Evolution of Biomolecular NMR. Submission Deadline: December 31, 2025 publishing.aip.org/publications... #NMRchat #NMR 🧲

Happy to hear, many congratulations Nicola! Best wishes for your (re)start in Padua

Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal and inspiring discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve.

Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB

We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics

With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...

I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩

AlphaFold is five years old — these charts show how it revolutionized science Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.

#AlphaFold is five years old — these charts show how it revolutionized science

40k citations

Alphafold database has been used by more than 3.3 million people worldwide

www.nature.com/articles/d41...

Happy to contribute to this work!

Looking back on an inspiring and stimulating two days at the Ultra-Highfield NMR and 4D Structural Biology Symposium. Huge thanks to all speakers, participants, and organizers for making this such an insightful and engaging event! 🧲🧬

Fantastic opportunity!
Great project with a great PI.
A no-miss opportunity

Highly endowed ERC Synergy Grant for Prof. Johannes Buchner Disease-causing proteins – ERC Synergy Grant for research at TUM on the role of chaperone “helper proteins.”

Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏

#ERCSyG #biotechnology
@erc.europa.eu

📷A. Heddergott

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

NMR TITAN user survey This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...

I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat

BPS2026 Annual Meeting | Biophysical Society The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI.  This year’s program…

Get important feedback from your community and move your work forward. Share your research at #bps2026!

Submit an abstract today buff.ly/oOjstk6

Helmholtz Munich Joins Germany’s Instruct-ERIC Centre for Structural Biology

#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬

Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.

👉 Read more: t1p.de/pjtyv

Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...

Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲

Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application?

Join the 10th European Solid-State NMR Summer School❗️

🗓️ October 20-24, 2025 | Garching, Germany

📌 Application Deadline: 01.09.2025

www.bio.nat.tum.de/ocb/upcoming...

#NMRchat #BioNMR

BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR

For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...

A general substitution matrix for structural phylogenetics. Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

Job details Job details

🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers

> Malene R. Jensen @ IBS Grenoble Research team of CNRS research director Malene Ringkjøbing Jensen at the Institut de Biologie Structurale, Grenoble, France

Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!