@sauerkrausi
Quantitative cell biologist. Image neurons, break organelles, wrangle proteomics data. Quantify everything except my cat's chaos. She's orange. π Alumni: @harvardmed.bsky.social @monashuniversity.bsky.social @lmu.de
More on the potential protective effect of LRRK2 variants in GBA1-PD: Researchers demonstrate that in response to IFNΞ³-induced inflammatory stimulation of #Parkinsons-patient derived microglia, LRRK2 kinase & GCase activities are positively correlated
www.nature.com/articles/s41...
Cutaway and close-up views of a Martini coarse-grained whole-cell model of JCVI-syn3A, showing the densely packed cytoplasm with proteins, RNA, metabolites, and chromosome inside a lipid membrane with embedded membrane proteins
Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell modelπ
Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social
That looks like an amazing resource!
No bull: This Austrian cow has learned to use tools.
Learn more: https://scim.ag/3LYTXNd
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the singleβmolecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasomeβribosome collisions.
www.biorxiv.org/content/10.6...
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes β revealing a new paradigm for lysosomal failure.
π doi.org/10.64898/202...
#CryoET
