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@impvienna

The IMP is a leading life science centre in Europe with 220 researchers from 40 countries. Part of the ViennaBioCenter.

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02.01.2024
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Latest posts by IMP @impvienna

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The new Vienna BioCenter Interdisciplinary Postdoctoral Program (VIPยณ) is here! We have 8 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.

The call is open!

More information: training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

02.03.2026 13:18 ๐Ÿ‘ 13 ๐Ÿ” 11 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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How does one genome create so much complexity?

๐Ÿ“ฝ๏ธ 2025 Birnstiel Award laureate Jimmy Ly discovered hidden protein variants in the โ€œdark proteomeโ€ that shape cell function and disease: https://youtu.be/wY1HbfY3fTE

02.03.2026 09:00 ๐Ÿ‘ 5 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐ŸŽ‰ Congratulations to our Ezra Levy, postdoc in Andrea Pauliโ€™s lab at the IMP, who has been awarded a prestigious Marie Skล‚odowska-Curie Postdoctoral Fellowship.

More about his project: https://www.imp.ac.at/news/article/ezra-levy-awarded-marie-sklodowska-curie-postdoctoral-fellowship

20.02.2026 12:00 ๐Ÿ‘ 15 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
SY-Stem 11. - 13. March 2026, Vienna (Austria)

Register online for SY-Stem: www.sy-stem.org.
SY-Stem โ€“ a symposium focusing on the next generation of stem cell researchers โ€“ is organized by IMBA and the IMP at the Vienna BioCenter.

13.02.2026 07:00 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Final registration reminder for SY-Stem 2026. The deadline is on Monday, February 16.

13.02.2026 07:00 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

@viennabiocenter.bsky.social

12.02.2026 19:24 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Catching viruses in the act of sabotage Viruses are masters of sabotage, they can disable the cellโ€™s antiviral defences and silence immune sensing systemsโ€”but this strategy can backfire. A collaborative study carried out by researchers at t...

Read more: www.imp.ac.at/news/article...

12.02.2026 19:22 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Viruses shut down antiviral defences to evade detectionโ€”but this can backfire. Researchers uncovered how human immune cells sense viral sabotage and trigger inflammation. UC Berkeley study with contributions from IMPโ€™s Moritz Gaidt: https://www.science.org/doi/10.1126/science.adw4937

12.02.2026 19:20 ๐Ÿ‘ 7 ๐Ÿ” 1 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
How cells import their waste disposal machine into the nucleus Proteasomes are the cellโ€™s waste disposal machines, breaking down damaged or unwanted proteins to keep cellular processes running smoothly. But to regulate gene activity, proteasomes must also enter t...

Read more: www.imp.ac.at/news/article...

@haselbachlab.bsky.social, @johanneszuber.bsky.social, @viennabiocenter.bsky.social

11.02.2026 10:21 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: https://www.nature.com/articles/s41467-026-69162-0

11.02.2026 10:20 ๐Ÿ‘ 19 ๐Ÿ” 8 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Sven Klumpe, joint Group Leader at the IMP and IMBA has received a grant by the Chan Zuckerberg Initiativeโ€™s Biohub to support fibsem-os, an open-source software platform for focused ion beamโ€“scanning electron microscopy.

Read more ๐Ÿ‘‰ https://imba.science/4tiwEP9

05.02.2026 10:15 ๐Ÿ‘ 19 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

@maxperutzlabs.ac.at, @viennabiocenter.bsky.social

02.02.2026 13:15 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Alipasha Vaziri | Research Institute of Molecular Pathology

https://www.imp.ac.at/achievements/research-milestones/alipasha-vaziri-neuronalactivity

02.02.2026 13:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ”ฌ Our Research Milestones essays are back!

This feature highlights Alipasha Vaziri, former Group Leader at the IMP and Max Perutz Labs.

At the IMP, he developed imaging technologies that enabled large-scale recording of neuronal activity at single-cell resolution:

02.02.2026 13:05 ๐Ÿ‘ 6 ๐Ÿ” 2 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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Paper alert! ๐Ÿ“ข How do cells fight viruses without harming themselves? ๐Ÿงฌ In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense โžก๏ธ tinyurl.com/4xbxz9e8

30.01.2026 11:05 ๐Ÿ‘ 22 ๐Ÿ” 9 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
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Job Opening: Technical Assistant

Apply to the technical assistant position at IMBA, IMP, and GMI: https://www.oeaw.ac.at/imba/career-education/open-positions/pos2601-technical-assistant
#research #jobs #europe #biology

30.01.2026 10:05 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We are hiring! Join our Sterile Processing Unit as a technical assistant and provide scientists at the IMP, IMBA, and GMI with sterile laboratory glass and plastic goods.

30.01.2026 10:05 ๐Ÿ‘ 4 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Studying immune cell fate inside the body of mice with CRISPR Plasma cells are the immune systemโ€™s antibody factories, but how B cells make the switch to become plasma cells has remained unclear. By developing a new in vivo CRISPR screening strategy, researchers...

More: www.imp.ac.at/news/article...

29.01.2026 08:44 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation | Journal of Experimental Medicine | Rockefeller University Press

https://rupress.org/jem/article/223/3/e20250594/281445/In-vivo-CRISPR-Cas9-screens-identify-new

29.01.2026 08:20 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Meinrad Busslinger at the IMP have now developed a new CRISPR screening strategy that allows gene function to be studied directly in immune cells inside living mice.

Using this approach, the team identified dozens of previously unknown genes that control plasma cell formation. Beyond new insights

29.01.2026 08:20 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Plasma cells are the immune systemโ€™s antibody factories, producing the molecules that protect us after infection or vaccination. They originate from B cell. Yet how B cells make the switch to become plasma cellsโ€”and which genes control this transitionโ€”isnโ€™t known.

Researchers from the lab of

29.01.2026 08:20 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Plasma cells are the immune systemโ€™s antibody factories, and they originate from B-cells.

Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:

29.01.2026 08:20 ๐Ÿ‘ 5 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A cellular strategy for building protein-making machines To keep cells running, ribosomesโ€”the molecular machines that make proteinsโ€”must be built continuously and with high precision. Now, researchers from the lab of David Haselbach at the IMP, together wit...

More: www.imp.ac.at/news/article...

@viennabiocenter.bsky.social, @haselbachlab.bsky.social, @lgrundmann.bsky.social

27.01.2026 15:33 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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New work from our Haselbach lab with collaborators captures ribosomes ๐˜ฎ๐˜ช๐˜ฅ-๐˜ฃ๐˜ถ๐˜ช๐˜ญ๐˜ฅ and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line.
Published in _Nucleic Acids Research _๐Ÿ‘‰ https://doi.org/10.1093/nar/gkag036

27.01.2026 15:33 ๐Ÿ‘ 20 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Check out our new paper in @natcomms.nature.com .com where we used #cryoEM together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast.

Publication: doi.org/10.1038/s41467-025-67685-6

Check below for the cryoEM centric feed. ๐Ÿ‘‡

27.01.2026 14:57 ๐Ÿ‘ 30 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
From one complex to many: Rethinking the BLOC/BORC system Two protein complexes that regulate intracellular transport and lysosome positioning were long thought to exist as single, well-defined entities. New structural insights now come from the groups of Da...

More: www.imp.ac.at/news/article...

21.01.2026 10:08 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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BLOC-1 and BORC help move and position lysosomes inside cells. New work from the Haselbach and Clausen labs shows they are not uniform complexes, but families of related protein assemblies. Published in PNAS: https://www.pnas.org/doi/10.1073/pnas.2515691123

21.01.2026 09:35 ๐Ÿ‘ 9 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
Seeing proteins fold as they are being made As ribosomes build new proteins, folding begins while the protein emerges. By capturing a chaperone, a helper protein, bound to a ribosome, researchers from the lab of David Haselbach and collaborator...

More: www.imp.ac.at/news/article...

19.01.2026 12:31 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐ŸงชScientists from our Haselbach lab captured how proteins begin to fold as theyโ€™re being made.

Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6

19.01.2026 09:40 ๐Ÿ‘ 51 ๐Ÿ” 16 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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SY-Stem 2026 brings two outstanding keynote speakers to the Vienna BioCenter. SY-Stem is a symposium focusing on the next generation of stem cell researchers, organized by the @impvienna.bsky.social & @imbavienna.bsky.social

March 11-13, 2026
Program and registration: www.sy-stem.org

15.01.2026 09:08 ๐Ÿ‘ 5 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0