PacBio

Decoding cancer requires resolving transcript diversity within intact tissue.

Join our webinar to see how long-read sequencing and near-single-cell spatial transcriptomics reveal isoform diversity and map immune receptor clonotypes in tumors.

Register: bit.ly/4bsBanl

#PacBio #CancerResearch

One molecule. Multiple layers of biology.

HiFi sequencing = multiomic insights.

It reveals the genome, structural variants, full-length isoforms, and base-level methylation. All in one run. All from the same molecule.

Get the full picture: bit.ly/3YSPBdo

#PacBio #HiFisequencing #Multiomics

What happens when a condition shifts from rare to widespread?

In Episode 3 of Beyond the Bench, Dr. Birgitt Scheule explains what it means to shift from studying isolated cases to addressing disease at population scale.

Watch now: bit.ly/4oLrOXu

#BeyondTheBench #PacBio #HiFisequencing

Color the future of genomics at PRISM 2026.

Join us to see how HiFi sequencing evolves in real time. Meet our experts in person and hear research already influencing study design and results for large-scale studies.

Secure your place: bit.ly/4slZxZs

#PacBioPRISM #PacBio

Heading to ACMG 2026 in Baltimore?

Visit PacBio at booth #2321 to see how HiFi sequencing is redefining genetic testing. Learn about the Vega system and how to consolidate assays for rare disease and PGx research.

Full program here: bit.ly/3OBZmee

#ACMGMtg26 #PacBio #HiFisequencing #ACMG

Want epigenetic information automatically included in your sequencing runs?

HiFi sequencing detects 5mC and 6mA directly from native DNA and combines multiple passes of the same molecule to generate long reads with greater than 99.9% accuracy.

See how: bit.ly/3YSPBdo

#PacBio #HiFisequencing

Rare Disease Month reminded us why we show up for families and the science driving answers.

We’re not stopping there. Pre-registration is open for Seq It Forward: Run for Rare 5K in June, supporting iHope and rare disease families.

Register: bit.ly/4u33kwB

#SeqItForward5K #PacBio #RareDisease #5K

Rare Disease Month has been about stories, science, and community.

Today on Rare Disease Day, PacBio is proud to sponsor San Diego’s event, standing with families, healthcare providers, researchers, and advocates advancing rare disease awareness and research.

#WeCareForRare #PacBio #RareDiseaseDay

#PacBio is proud to join the International Rare Diseases Research Consortium (IRDiRC)!

We’re joining forces with global stakeholders to advance rare disease research and equitable genomic discovery. Together, we move forward.

Details: bit.ly/4b8PqkW

#WeCareForRare #RareDisease #RareDiseaseMonth

Rare disease month: Activating the community through hackathons - PacBio Rare disease hackathons bring together bioinformaticians, scientists, clinical geneticists, and variant analysts to solve unresolved cases.

Rare disease research works best when communities unite.

This week’s blog explores hackathons where clinicians, researchers, and families collaborate to solve cases, share insights, and strengthen networks that advance progress worldwide.

Full blog here: bit.ly/4ucRXlU

#WeCareForRare #PacBio

🔬A few amino acid changes can shape whether a lens stays clear for decades or begins to cloud.

In Episode 2, Dr. Andor Kiss explains how his team traces differences tied to stability, adaptation, and cataracts and shares three key findings.

Watch now: bit.ly/4oLrOXu

#BeyondTheBench

HiFi sequencing can reveal rare and complex variants, but interpretation requires diverse background datasets.

PacBio and DNAstack are supporting the first global federated dataset of HiFi whole genomes through the HiFi Solves Global Consortium.

Details: bit.ly/4kQ0bMk

#WeCareForRare

The PacBio mission is about more than the technology we build. It’s about showing up for families.

For Rare Disease Month, we assembled 100 care packages for There With Care to support those facing critical illness and medical crises.

We are proud to show #WeCareForRare.

#RareDiseaseMonth

Miami Biology professor featured in DNA sequencing video series Andor Kiss appears in PacBio's Beyond the Bench series discussing DNA sequencing technology

New from Miami University: Dr. @andorjkiss.bsky.social and his lab’s work featured in BEYOND THE BENCH.

Students are generating long-read sequencing data in-house and learning how sequencing strategy shapes discovery.

Read the story: bit.ly/4aFSgMS

#BeyondTheBench #PacBio #HiFisequencing

Radboud UMC research highlights promise of HiFi long-read sequencing to match standards of care in rare disease genomics - PacBio HiFi WGS could actually improve or refine the genetic diagnosic findings in an estimated 3.4 percent of rare disease cases.

For people with rare diseases, delayed explanations are a burden. New data from @radboudumc.bsky.social shows HiFi genomes can help replace a patchwork of tests with one unified approach. This consolidation provides clearer explanations sooner.

Read more: bit.ly/4tB04bs

#WeCareForRare #PacBio

🦖 Alligators survived. Dinosaurs did not. Why?

In Episode 2 of BEYOND THE BENCH, Dr. Andor Kiss uses HiFi long-read sequencing on Vega to resolve crystallin isoforms across species and reveals changes tied to cold adaptation and cataracts.

See how he did it: bit.ly/4oLrOXu

#PacBio

Meet Elfride De Baere, Head of Clinic at Ghent University Hospital’s Center for Medical Genetics. She shares why PacBio long-read sequencing + a multiomic approach (genomics + transcriptomics) can help deliver clearer insights for families.

#WeCareForRare #RareDiseaseMonth #GeneticEyeDisease

Repeat expansions and complex regions still challenge PCR and short reads.

See how labs use PureTarget with PCR-free HiFi sequencing of native DNA to build scalable custom panels and improve confidence across difficult loci.

Save your spot: bit.ly/3MElTWS

#PacBio #PureTarget #HiFisequencing

💖 Feeling Solo this year?

Back by popular demand, Alex Dainis’ dating profile video shows how finding the right sequencing tech can feel like dating, with lots of mismatches before the perfect match.

See why HiFi on Vega is the perfect match + ask about out our new promos: bit.ly/3M6VmBi

Key takeaway from Dr. Santosha Vardhana in Beyond the Bench:

When T cells run low on energy, they make priority decisions that shift into self preservation mode. That bioenergetic limit shapes immune exhaustion.

Watch the full episode: bit.ly/4oLrOXu

#BeyondTheBench

Rare Disease Month: Taking a People-First approach in the global fight against rare disease - PacBio For Rare Disease Month, we’re sharing stories across the globe that connect the data to the lives of the families at the center of it.

Rare disease is more than statistics. It is lived every day by families searching for answers.

For Rare Disease Month, we share global, People-First stories showing how earlier genomics and long-read WGS can shorten diagnostic journeys.

Details: bit.ly/3ZyEczS

#WeCareForRare #PacBio #RareDisease

Progress in rare disease research starts with access.

#PacBio is proud to join iHope, a global initiative of Genetic Alliance, bringing long read whole genome sequencing to underserved families worldwide. Because progress should be global and within reach.

Details: bit.ly/3OFfviI

#WeCareForRare

PacBio PRISM 2026 brings the genomics community together to explore what’s next.

Inspiring keynotes, focused breakouts, direct access to PacBio experts, and a global network of peers all in one collaborative setting.

Learn more here: bit.ly/4cnaPYJ

#PacBioPRISM

Happening this Thursday: learn how SPRQ-Nx chemistry on the Revio system supports scalable HiFi genomes and multiomic discovery at a lower cost.

Hear real-world data from early-access users and explore expanded methylation calling.

Register: bit.ly/4qLqV2Q

#PacBio #SPRQNx #HiFisequencing

Experts from GSK, Pfizer, AstraZeneca, and UCL share how PacBio HiFi sequencing is advancing #biopharma R&D, from AAV characterization to mRNA vaccine CQA and antibody screening.

Watch the teaser and access the full session on-demand: bit.ly/49BMHOY

#PacBio #HiFisequencing #DrugDiscovery

How SPRQ-Nx enables affordable long-read whole genome sequencing without added complexity - PacBio With the introduction of SPRQ-Nx, HiFi sequencing has now become the most affordable long-read sequencing technology to date.

You’ve heard the buzz around a more affordable long-read genome with SPRQ-Nx. Now we’re letting the data do the talking.

Newly published WGS datasets across human, plant, and animal genomes show you don’t need to compromise data quality for affordability.

Explore the data: bit.ly/3O7BAGv

#PacBio

Beyond the Bench: Advancing cancer transcriptomics with HiFi long-read RNA sequencing - PacBio This series offers a chance to step beyond the data and hear directly about the habits and motivations that drive their research

Not all immune cells behave like the textbooks say.

New blog: Dr. Santosha Vardhana shows how HiFi long-read RNA is exposing hidden transcript isoforms + real immune diversity in cancer datasets.

If you build hypotheses off single-cell data, this one’s worth a read: bit.ly/4rypwN3

#BeyondTheBench

Choosing automation for HiFi sequencing is not one size fits all.

The new PacBio Automated Workflow Selector helps labs match their project needs to PacBio compatible automation options across extraction, shearing, and library prep.

Explore here: bit.ly/469CfxB

#PacBio #SLAS2026

#PacBio supported the Wilhelm Foundation Undiagnosed Hackathon in Hyderabad, India, helping clinicians & researchers tackle unsolved cases with HiFi sequencing.

This tech reveals genetic variation others miss and accelerates #RareDisease discovery.

Read more here: bit.ly/4knIT9m

Why do people fall in love with biology? 

For Dr. Santosha Vardhana, it’s awe at how much the human body gets right. That sense of wonder still shapes how he thinks about cancer, the immune system, and discovery. 

Watch his story in BEYOND THE BENCH → bit.ly/4oLrOXu

#BeyondTheBench