Holger Heyn

Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes - Oncogene Oncogene - Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes

📢New paper out in Oncogene!

➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)

📎 www.nature.com/articles/s41...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer - Nature Communications ‘T cell engagers promote antitumor immunity, but how macrophage modulates this activity in tumor is still unclear. Here the authors show, using biopsies from patients with uveal melanoma and single ce...

🚀New research published in @naturecomms.bsky.social!
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG

📎 www.nature.com/articles/s41...

🌟Big step in #PrecisionMedicine: CNAG publishes an inflammation atlas with 6.5 million single cells from 1,047 patients across 19 diseases!

🎯Key to understanding inflammation in infections, autoimmune diseases & cancer
Led by @hoheyn.bsky.social, under Doctis Proj.

www.biorxiv.org/content/10.1...

🌎 This week, we crossed the ocean to Canada to take part in the @keystonesymposia.bsky.social #SingleCell Biology: Unique Cells to #Tissue Ecosystems

🗣️ Our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, presented “The Power of a Million Cells”

#KSSingleCell25 #KeystoneConferences

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas. The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

Ever wondered why we do all these #Omics?
Here is your answer: biorxiv.org/content/10.1... 📜

Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.

TICK tock. Your Immune clock is ticking! -Immune Age-
@omniscope.bsky.social is launching a suite of Immune Tracking products at #MWC2025

Immune Age uses T cells as living sensors, a new Biomarker strategy to quantify #BiologicalAge (@erictopol.bsky.social : erictopol.substack.com/p/steve-horv...)

YOU NEVER WALK ALONE 💛 🖤 🤍

Building a company is no easy task—but doing it with friends is a recipe for success.

Thanks so much to my co-founders Vijay and Lynnette
@omniscope.bsky.social and @fcbarcelonamain.bsky.social
for your support! 🔥

Excited to collaborate with @hoheyn.bsky.social, @jcnietos.bsky.social, @paulanietog.bsky.social & team on leptomeningeal metastatic disease - a key challenge in #NeuroOncology. Our study reveals unique immune responses in CSF, highlighting CSF liquid biopsy’s potential to guide CNS tumor therapies.

XMAS Exercise: #review writing
T Cell Sequencing for Next-Gen Clinical Diagnostics

Every day until Christmas, I’ll be dropping #TCR-seq insights to better Detect and Treat!

Get your socks ready for a daily boost of Science to balance out the holiday sugar rush.
#ScienceIsWeAll

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer Immune checkpoint inhibition (ICI) has revolutionized oncology, offering extended survival and long-term remission in previously incurable cancers. While highly effective in tumors with high mutationa...

The REAL Superpower of Deep T Cell Sequencing!

We tracked #singlecell from Tumor to Blood.
We identified ICI-induced T cells.
We quantified T cell memory.
We designed personalized TCR-T therapy.

Amazing collab w/ Omniscope, CNAG and @irbbarcelona.bsky.social.

www.biorxiv.org/content/10.1...

Adaptation in human immune cells residing in tissues at the frontline of infections - Nature Communications Immune cells are under evolutionary pressure due to their anti-infective defence role. Here Salvador-Martínez and Murga-Moreno et al. combine population genetics approaches and Human Cell Atlas data, ...

OUT NOW!

Adaptive Evolution of the Human Immune Cell Landscape.

"Human adaptation controls pathogen spread at early stages of infection with specific states at strategic barrier sites".

Our (late) contribution to the HCA-Nature bundle.

www.nature.com/articles/s41...