Jakub Kopal

Out now in #natBME: We explore how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD).

nature.com/articles/s41...

#Multimorbidity is a pressing challenge in health care.
We dissect its genetic architecture across mental and physical health, revealing shared and distinct links between brain structure, psychiatric disorders, and cardiometabolic disease.
www.medrxiv.org/content/10.1...

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets Linear mixed-effects (LME) models are commonly used for analyzing longitudinal data. However, most applications of LME models rely on random intercepts or simple, e.g., stationary, covariance. Here, w...

Introducing FEMA-Long for high-dimensional large-scale mixed-effects modelling! Includes modelling unstructured covariance, non-linear effects using splines, time-dependent effects with spline interactions, and longitudinal GWAS with time-dependent genetic effects!
www.biorxiv.org/content/10.1...

Great collaborations with @alaindagher.bsky.social @danilobzdok.bsky.social @ndrewvo.bsky.social !

Understanding #Parkinsons subtypes is key to more targeted RCTs & better therapeutics! 🧠 Our new study finds that LRRK2 PD patients show milder cortical atrophy, with preserved temporal & occipital regions compared to sporadic PD. #LRRK2 #dataviz

www.medrxiv.org/content/10.1...

Postdoctoral Fellowship in Mental Health Research (272560) | University of Oslo Job title: Postdoctoral Fellowship in Mental Health Research (272560), Employer: University of Oslo, Deadline: Monday, February 24, 2025

Want to get out of Dodge? Do a postdoc @uio.no! You will be using the MoBa study and registers to study intergenerational transmission and GxE for #MentalHealth and #education using @behaviorgenetic.bsky.social and @pgcgenetics.bsky.social approaches. Please share!

www.jobbnorge.no/en/available...