NYU Pain Research Center

NYU Research Competes for This Year’s Top Health Discovery Recent studies of C-sections, gut pain selected for STAT Madness 2026

Support groundbreaking science revealing how gut microbes drive intestinal pain! Vote for our PAR2 discovery in STAT Madness 2026.

@sarahanajjar.bsky.social @karapedsgastrodoc.bsky.social

We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social

@karapedsgastrodoc.bsky.social @mariafialho.bsky.social

NEW PREPRINT 🚨 Why does IBS pain persist? PRC’s Nestor Jimenez-Vargas and the Bunnett Lab uncover how PAR2 signaling from endosomes amplifies fleeting histamine signals to sustain colonic nociceptor hyperexcitability. www.biorxiv.org/content/10.6...
@badrsokrat.bsky.social

Amazing opportunity!

On the cover of Science Signaling! Work in the Ye lab, led by Naijiang Liu and Xiaojie Shi, shows that blocking epidermal growth factor receptor signaling reduces oral cancer pain AND boosts opioid efficacy. www.science.org/doi/10.1126/...

Proud of Dr. Yi Ye and her team's outstanding work advancing our understanding of oral cancer pain and opioid tolerance. Check out the press release on these important findings! www.nyu.edu/about/news-p...

#PainResearch #DrugDiscovery #NRP1 #VEGF @karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @pazduran.bsky.social

Quinoline-Based Neuropilin-1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain Nociceptive pain, resulting from tissue injury or inflammation, affects a large portion of the global population. This type of pain is commonly treated by small molecules that are associated with a va...

Exciting work introduces EG01449 (12h), a novel Neuropilin-1 (NRP1) antagonist. It inhibits NRP1, avoiding signaling drawbacks, and blocks VEGF-induced pain by mitigating channel currents in sensory neurons. NRP1 antagonism is a promising new modality for chronic pain. pubs.acs.org/doi/10.1021/...

What a day! ✨ The 1st NYC Area Pain Research Meet-Up blew us away — amazing energy, brilliant conversations, and an incredible community. Huge thank-you to everyone who attended and to all who helped bring this event to life. Already excited for the next one!

PRC’s very own Associate Director, Steve Davidson, PhD, took the spotlight as our Keynote Speaker at the 1st NYC Area Pain Research Meet Up! 🎤✨
Talk Title: Humanizing Pain Neurobiology for Translational Gain.

✨ Sponsor Spotlight! ✨
Huge shoutout to Tactorum — leading the way in improving preclinical pain research and pushing the field forward. We’re grateful for your support! 🔬💡

Amazing start to the first NYC Area Pain Research Meeting with the Pain Research Center. More photos to come!

What a day! ✨ The 1st NYC Area Pain Research Meet-Up blew us away — amazing energy, brilliant conversations, and an incredible community. Huge thank-you to everyone who attended and to all who helped bring this event to life. Already excited for the next one!

PRC’s very own Associate Director, Steve Davidson, PhD, took the spotlight as our Keynote Speaker at the 1st NYC Area Pain Research Meet Up! 🎤✨
Talk Title: Humanizing Pain Neurobiology for Translational Gain.

✨ Sponsor Spotlight! ✨
Huge shoutout to Tactorum — leading the way in improving preclinical pain research and pushing the field forward. We’re grateful for your support! 🔬💡

Amazing start to the first NYC Area Pain Research Meeting with the Pain Research Center. More photos to come!

Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social

🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology

@farnazshamsi.bsky.social @karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social

The NYU PRC is excited to welcome Farnaz Shamsi as one of our newest associate members! 🎉 Farnaz studies the neuroimmune regulation of energy balance and adipose tissue function, exploring how these systems shape metabolic health and contribute to obesity and related diseases.

An enteric-DRG pathway for interoception and visceral pain in mice Wang et al. reveal a neuroanatomical and functional crosstalk between cholinergic enteric neurons and sensory neurons of the dorsal root ganglia that mediates colonic interoception. While this pathway...

Enteric neurons join the pain conversation! New paper shows that cholinergic circuits in the colon signals through DRG pathways, especially after inflammation. www.cell.com/neuron/fullt...

Are you a researcher in #touch #pain #itch #somatosensation or #interoception? Come join us at the Somatosensation and Interoception social at #Sfn2025! Co-hosted with
@karalmarshall.bsky.social @sdavidson.bsky.social

@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @tonelloraquel.bsky.social

A Reference Atlas of the Human Dorsal Root Ganglion Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...

New insights into human sensory biology: The human DRG atlas is here. #painresearch #DRG #neuroscience www.biorxiv.org/content/10.1...

🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology