Paul Hoskisson 🧫 🦠🐸

Paralog interference contributes to the preservation of genetic redundancy Duplicated self-interacting proteins can interact and interfere with each other’s function. Cisneros, Mattenberger, et al. show that selection against interfering loss-of-function alleles extends the ...

Really fantastic piece of work from @christianlandry.bsky.social et al.,
-elegant set of experiments to uncover mechanisms that contribute to understanding of duplicate retention & redundancy-
Paralog interference contributes to the preservation of genetic redundancy www.cell.com/current-biol...

Friday was a great day to record my #MattersMicrobial podcast. I had the best time chatting with Dr. Paul Hoskisson about Streptomyces, antibiotics, and evolution. It will be available in two weeks or so. Remember, I am now recording podcasts every other week. @paulhoskisson.bsky.social

Heads up, members: online membership transactions will pause from 17:00 (UK time) on 13 January until 27 January 2026 while we prepare our new members area. Event bookings, grants and renewals will be temporarily unavailable. Read the full update 👉 https://microb.io/3MhXean

Powerful Anti-Cancer Drug Discovered Inside Japanese Tree Frog Scientists have discovered a promising new approach to fighting cancer in the gut bacteria of a Japanese tree frog, with one strain completely shrinking tumors in mice, with no severe side effects.

Powerful Anti-Cancer Drug Discovered Inside Japanese Tree #Frog - www.sciencealert.com/powerful-ant...

poisonfrogs: Color Palettes Inspired by Neotropical Poison Frogs laurenoconnelllab.github.io/poisonfrogs/ #Rstats

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.

www.nature.com/articles/s41...

A thread.

#459 - Crick: A Dialogue with Matthew Cobb Podcast Episode · Converging Dialogues · 22/12/2025 · 1h 15m

Really great episode of @convergingdialogues.skystack.xyz podcast with @matthewcobb.bsky.social on his new biography Crick - wonderfully engaging as always and a great conversation with @xavierbonilla.bsky.social - well worth a listen! podcasts.apple.com/gb/podcast/c...

Yes: deleterious recessives aren’t completely recessive! An important study confirming intuitions from at least some of us.

Danna Gifford School of Biological Sciences | Faculty of Biology Medicine and Health | University of Manchester

‪Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky

@frimanscience.bsky.social great to see you man, hope to hang out soon!

@seanmeaden.bsky.social good to see you Sean!

Super meeting, and @microbiologysociety.org staff organisation was incredible as always! This meeting really fills a niche in evolutionary microbiology, let make sure it runs again! Great to see old friends and make new ones @gmknght.bsky.social

Absolutely brilliant #MicroEvo25 some great talks and talent that has me thinking about our research. And great to catch up with @brockhurstlab.bsky.social @craigmaclean.bsky.social @paulhoskisson.bsky.social
@lore-fermar.bsky.social @julieakmcdonald.bsky.social @lucyweinert.bsky.social and more

I’m sure I will Matthew, if it’s half as good as your others! cheers P

Just arrived - very excited to read @matthewcobb.bsky.social ‘s latest

Genomic architecture of egg mimicry and its consequences for speciation in parasitic cuckoos Host-parasite arms races facilitate rapid evolution and can fuel speciation. Cuculus cuckoos are deceptive egg mimics that exhibit a broad diversity of counterfeit egg phenotypes, representing host-ad...

Incredible paper - Genomic architecture of eggmimicry and its consequencesfor speciation in parasitic cuckoos www.science.org/doi/epdf/10.... and a great commentary here www.science.org/doi/epdf/10.... @btobirds.bsky.social

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

@papersapp.com hi guys, is this a bug, I’ve noticed in the last couple of weeks on chrome - when clicking ‘save PDF to Papers by ReadCube’ - the dialogue box is blank? Is there a way to fix? It’s running v4.37.2395

Two full-time positions | Bioinformatician (m/f/d) + Applications Specialist (m/f/d) - Molecular Biology The Genome Facility at the Max Planck Institute for Evolutionary Biology in Plön is seeking to fill two positions (full time) to support and expand our core facility services.

Two new positions are available at the MPI for Evolutionary Biology to support development of our genomics facility. Both stand to become permanent. Both offer a ton of opportunity to engage in a wide range of creative science.

Pls repost 🙏

www.evolbio.mpg.de/3838377/job_...

Please pass on my condolences to Saskia

‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands The items to be returned, which include Java Man, were collected during the colonial era

‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands - well done @naturalis.bsky.social www.science.org/content/arti...

Wow - this is awesome!!

Filamentous cheater phages drive bacterial and phage populations to lower fitness Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...

Our new preprint by @nanamikubota.bsky.social shows that P. aeruginosa, and likely many other bacteria carrying filamentous prophages (like V. parahaemolyticus), risk being exploited by these phages in a runaway process that reduces fitness of both host and virus. www.biorxiv.org/content/10.1... 🧵

Apply for a #PhD with @paulhoskisson.bsky.social and me on all things #Streptomyces, #evolution, #AMR, #antibiotics, #biotech!

Deadline 21st November. #MicroSky please share!

Today was the first day of life after my @raeng.org.uk Research Chair - the award was transformative to me and our team and I’ll be forever grateful to the Academy for supporting our science and vision of how it was time for synthetic biology and engineering biology to deliver for industry

A teal flyer for a PhD opportunity to investigate how warming may change antimicrobial resistance. The project will use experiments on Klebsiella bacteria to answer questions about how temperature affects their response to antibiotics, plasmid transfer, and fitness costs. The research involves microbiology lab work, bioinformatics, and mathematical modeling. The flyer includes contact details for Dr. Daniel Padfield and the logos of the sponsoring institutions.

I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky

Please share the ad below with anyone who may be interested.

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

Generative design of novel bacteriophages with genome language models Many important biological functions arise not from single genes, but from complex interactions encoded by entire genomes. Genome language models have emerged as a promising strategy for designing biol...

This is super cool from @brianhie.bsky.social et al-
Generative design of novel bacteriophages with genome language models www.biorxiv.org/content/10.1...

‘You’re going about your day and suddenly see a little Godzilla’: Bangkok reckons with a giant lizard boom Viral videos have shifted public opinion about water monitors, long held in contempt in Thai culture, even as rising numbers of the reptiles pose problems for residents

www.theguardian.com/environment/...

Some good stuff in here 😊