Stije Leopold 🦠🔬💊

Weekly respiratory viruses update:

- #influenza circulation remains HIGH with early signs of a new INCREASE
- #RSV circulation ELEVATED and INCREASING
- #SARSCoV2 circulation remains at LOW levels.

More info: erviss.org
#ERVISS #RespiratoryViruses #IDsky #EpiSky #COVID19

Weekly respiratory viruses update:

- #influenza activity is high but has peaked
- #RSV circulation is elevated and increasing,
- #SARSCoV2 circulation remains at low levels.

More info: erviss.org
#ERVISS #RespiratoryViruses #IDsky #EpiSky #COVID19

Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective... Universal infant nirsevimab prophylaxis markedly reduced RSV-related hospitalisations and outpatient morbidity, with sustained reductions in RSV-related LRTI hospitalisations into the second season an...

New Research

Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective observational study

www.thelancet.com/journals/lan...

An integrated surveillance study of SARS-CoV-2, influenza virus, and respiratory syncytial virus infections We aimed to describe recent epidemiological trends of SARS-CoV-2, influenza virus (A/B), and respiratory syncytial virus (RSV) in the canton of Geneva, Switzerland, using data from the Sentinella netw...

📣 #Wastewater surveillance is a powerful tool. In this integrated molecular epidemiologic study of >1000 patients with #influenza, #RSV, or #Covid, it correlates year after year with number of inpatient + ambulatory cases.

#IDSky #clinmicro #ViroSky #EpiSky #OA
www.cmi-comms.org/article/S295...

Early ECDC seasonal influenza vaccine effectiveness estimates w41-49 2025 in EU/EEA.

44% (95% CI: 25–59) against any influenza;

52% (95% CI: 29–69) against influenza A(H3N2);

16% (95% CI: -43–54) against influenza A(H1N1)pdm09.

75% (n=553) influenza A(H3N2),
25% (n=183) influenza A(H1N1)pdm09

Early estimates of seasonal influenza vaccine effectiveness against influenza requiring medical attention at primary care level in Europe, week 41 - 49, 2025 The 2025/26 influenza season has begun earlier than the previous two seasons, driven by the recently-emerged influenza virus A(H3N2) subclade K.

🤧 The 2025/26 flu season has begun earlier than the previous two seasons, driven by the recently-emerged influenza virus A(H3N2) subclade K.

An ECDC study estimated early seasonal influenza vaccine effectiveness across the EU/EEA.

Learn more: www.ecdc.europa.eu/en/news-even...

#EpiSky #IDSky

Why not in Papyrus??? No but really, whats the size legend?

Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 This comprehensive analysis underscores both the gains achieved through vaccination and the challenges that remain in controlling the LRI burden globally. Furthermore, it demonstrates persistent dispa...

New Research

Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

www.thelancet.com/journals/lan...

Weekly respiratory viruses update:

- #influenza activity is increasing rapidly and circulating widely,
- #RSV is slowly increasing,
- #SARSCoV2 circulation continues to decrease.

More info: erviss.org
#ERVISS #RespiratoryViruses #IDsky #EpiSky #COVID19

NHS bracing for worst ever winter crisis in next fortnight amid rising flu cases Hospitals treating record numbers of flu patients but worst is yet to come as medical bosses urge people to get vaccinated

#NHS bracing for worst ever winter crisis in next fortnight amid rising #flu cases

Shereen Hussein tells @theguardian.com 'safe connection should be priority' & urges people to check on welfare of older relatives & neighbours, & take them to be vaccinated.

www.theguardian.com/society/2025...

#Vaccination is effective against clinical disease caused by #influenza A(H3N2)

A study from the UK found the typical range of #vaccine effectiveness in line with age groups (2−12 years, 18−64 years & ≥ 65 years) against emergency department attendance or #hospitalisation

#IDSky #MedSky #EpiSky 🛟

#Flu in the UK - what you need to know

Listen to LSHTM Viral podcast on flu pod.link/1497329104/e...

Read more from our experts: www.lshtm.ac.uk/newsevents/n...

#PublicHealth

Our unit is conducting an adaptive platform trial comparing oseltamivir, favipiravir and baloxavir. For real influenza pandemic preparedness, I think we are eventually going to need a combination of these antivirals #ECDC #100DaysMission #IPPS #WHO #FAO #MedicinesPatentPool #MORU

Bird Flu (H5N1) shows more and more signs of adapting to mammals (and thus to humans!). This new ECDC report includes a scenario matrix for pre-pandemic zoonotic influenza preparedness. They also mention the use of antivirals.

www.ecdc.europa.eu/en/publicati...

Calling all researchers working in #InfectiousDiseases #EmergingInfections or #NTDs? You can use our free tools, resources to support your work www.iddo.org/tools-and-re...
#BeatNTDs

The UK isn’t prepared for the next pandemic – and nor are many other countries.
kucharski.substack.com/p/we-arent-p...

100 Days Mission Pandemic PACT is a powerful tool to track data about research funding and evidence for a wide range of diseases with outbreak potential and broader preparedness activities.

📊 Pandemic PACT has launched its new 100 Days Mission Dashboard: an interactive look at global health research grants aligned with 100DM goals.

💡 Collaborating with the IPPS, the dashboard helps track progress toward faster diagnostics, therapeutics & vaccines

www.pandemicpact.org/visualise/po...

Generation of antigen-specific paired-chain antibodies using large language models MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addres...

#NatMicroPicks

AI to design therapeutic antibodies! 🧪⚕️

AI-driven monoclonal antibody generator designs novel antibodies without templates, targeting SARS-CoV-2, H5N1, and RSV-A

#MicroSky

www.cell.com/cell/fulltex...

Widespread avian influenza in birds increases risk of human exposure This autumn has seen an unprecedented surge in detections of highly pathogenic avian influenza A(H5N1) virus in wild birds, accompanied by many recent outbreaks in domestic poultry across affected are...

Actions to be taken:

• monitor exposed people for 10–14 days
• if symptoms appear, self-isolate and seek testing
• health-care workers in affected areas should ask patients with flu-like symptoms about recent contact with animals.

Read more:
www.ecdc.europa.eu/en/news-even...

Table of content issue 46 in 2025 Rapid communication Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance Global distribution of Xpert CT/NG assay Neisseria gonorrhoeae escape variants indicates sporadic emergence with limited clonality between 2016 and 2025 Outbreaks Investigation of a measles outbreak in a highly vaccinated middle school, France, 2023 Concurrent outbreaks of Escherichia coli O157:H7 and O157:H39 with high asymptomatic carriage of other Shiga toxin-producing E. coli in nursery children, south-east Scotland, United Kingdom, July to October 2022

In our new issue, @ukhsa.bsky.social authors describe the early start to this year's #flu season in England with dominating #influenza A(H3N2) subclade K

Conclusion: #vaccination is effective against clinical disease caused by A(H3N2) viruses

🗞️ bit.ly/EUS3046

#IDSky #EpiSky #MedSky #PedSky 🛟🧪🦠

📣 New #Communicable drops Mon 3 Nov!
@anniejoseph.bsky.social & Nav host @andre-siqueira.bsky.social (Brazil) & Steven Lim (Malaysia) to discuss #dengue as a rising global health burden, how to diagnose & manage it, and what's in the therapeutic pipeline 🔍

@dndi.org #denguealliance #IDSky