Mcclelland lab

What a lovely comment and I should say this echos the performance of Laura in my lab too! ❤️❤️❤️

Driving discoveries for tomorrow's cancer care at Barts Cancer Institute YouTube video by BCIQMUL

Today, on #WorldCancerDay, we’re taking you behind the scenes at Queen Mary's Barts Cancer Institute and introducing you to the people who are making progress possible.

Follow us to stay up to date with new developments.

🧪 #UnitedByUnique #MedSky #OncoSky @qmul.bsky.social @cancerresearchuk.org

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social

4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence

Applications open now: www.imperial.ac.uk/jobs/search-...

A breakage–replication/fusion process explains complex rearrangements and segmental DNA amplification - Nature Genetics This paper introduces breakage–replication/fusion, a genomic rearrangement process underpinning three patterns of copy-number gains found in cancer and other diseases.

www.nature.com/articles/s41...

4 months ago I boasted of two papers accepted in two days. In the interests of transparency I should also post that this week we had two papers rejected (or stalled). I wish this process was a little less demoralising, it’s the most important thing we have to do!!! Be nice people!

Order of cancer-driving mutations affects the chance of tumour development Scientists reveal that mutation order influences tumour growth in the intestine.

www.sanger.ac.uk/news_item/or...

Arriving at work. That’s the moon.

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍

The mighty yeast reveals what we believe are general principles of centromere evolution!

Behind the curtain: communities.springernature.com/posts/counti...

#MEvoSky 🧪🌎

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.

Application deadline: 24 December

www.crick.ac.uk/careers-stud...

differential contribution of H3K9 methyltransferases to boundaries at satellites

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...

Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...

Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...

Lab website has been updated including a very nice news section! Www.mcclellandlab.com/news

Ready to start your own independent research programme?

We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk

Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...

#EarlyCareerResearchers #GroupLeader #ScienceCareers

Senior Research Technician at University of Birmingham Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social

Last day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston!
Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!

Professors x 10, Faculty of Medicine & Dentistry | Veredus QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

congrats! But how do you tell each other apart??

Dosage responses of aneuploid autosomal chromosomes https://www.biorxiv.org/content/10.1101/2025.09.18.677044v1

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs

www.cell.com/cell-reports...

Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...

Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...

The ‘surprise baby’ of papers, we trained visiting lecturer from Thailand 🇹🇭 Raksawan, who co-led by @nadeemshaikh.bsky.social and @mollyguscott.bsky.social produced our first work investigating CIN in Cholangiocarcinoma (prevalent in Northern🇹🇭 ). Congrats to co-corr author @nadeemshaikh.bsky.social!

🎉 Join us in congratulating four BCI researchers who have been promoted!

Promoted to Professor:
🔹Professor Angus Cameron
🔹Professor Jun Wang

Promoted to Senior Lecturer:
🔹Dr Diu Nguyen

Promoted to Reder:
🔹Dr Miguel Ganuza

@qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social