that sounds fair!
11.02.2026 21:38
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that sounds fair!
Citation nonsense.
Our paper on Ryanodine Receptor disease mutations gets cited in a paper about nanocellulose...
advanced.onlinelibrary.wiley.com/doi/full/10....
Journals could use an AI tool to weed through irrelevant citations. Or is this entire paper an AI hallucination?
A pity for the field that 8+ years have passed between publication and retraction, or even the several years after the first concerns were raised. Kudos to Schrag and coworkers to keep pushing for honest science!
I just did an interview in the Sueddeutsche Zeitung about how we detect cold temperatures — the journalist, Felix Hütten, did a nice job to make it accessible also for non-scientists.
www.sueddeutsche.de/gesundheit/m...
Thanks to the UBC media team for coverage of our statin : RyR1 work. Atorvastatins bind and trigger opening of a calcium release channel critical for muscle contraction.
news.ubc.ca/2025/11/ubc-...
@ubcmedicine.bsky.social
For the aficionados: we find that 3 statin molecules bind per subunit of RyR1 (12 for a full tetramer). The statins also interact with one another, highlighting an unusual binding mode.
Work spearheaded by Steven Molinarolo.
Special thanks to people at our in-house EM facility
@hrmem.bsky.social
Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/...
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
Very interesting paper from Susan Hamilton's lab, showing that phosphorylation of RyR1 by SPEG kinase can suppress pathological consequences of disease mutations.
www.science.org/doi/10.1126/...
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
Hope this isn't going to apply to anyone already on H-1B, but only future ones.
www.science.org/doi/10.1126/...
A study in collaboration with Frank Bosmans. Reproducible protocol to measure the elusive NaV1.9 currents, and revealing a big role for the preIQ region in gating properties.
unconscious bias...
Still a few days left to apply for a faculty position focused on cardiac arrhythmias at Simon Fraser University. Come join the greater Vancouver network on arrhythmia research!
www.academicwork.ca/jobs/assista...
seems you can definitely forget about BLAST with an entire RyR sequence...
hopefully not a symptom of funding cuts and resignations at NIH
Is it just me or is Pubmed down...??
Well done Kookjoo Kim on a great poster presentation, here visited by an RyR VIP, @filipvanpetegem.bsky.social!
And thanks @biophysicalsoc.bsky.social, @popstarlab.bsky.social & team for a great #BPS2025 under challenging circumstances - see you next year in SF!
Stress in action: our crystal structure of PKA bound to its preferred substrate in CaV1.2 (Ser1981 for the aficionados). Quantitative experiments on previously proposed sites in CaV1.2 and its regulator Rad shows that there are two tiers of substrates.
jbc.org/article/S002...
an invitation to talk on the Galapagos Islands?
seconding this. It also applies to presentations. The perfect way to throw off your audience is to use highly specific jargon and acronyms to an audience that is not (fully) in your field
Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting.
(description also here: www.science.org/doi/10.1126/...)
#CryoEM
Every day since the late 1920s (except during WWII), the notes of the Last Post sound through the Menin Gate in Ypres, Belgium. Unfortunately, "never again" hasn't stuck. #ArmisticeDay
Can you find out which ion binds your protein using cryo-EM? This new method from Bonnie Murphy's lab combines electron energy loss spectroscopy and single particle imaging, showing this can become posssible. Test case on our favorite protein, the Ryanodine Receptor.
www.nature.com/articles/s41...
Our latest cryo-EM study, elucidating the type 3 Ryanodine Receptor (RyR3) in different conformational states
nature.com/articles/s4146…
Unexpected binding sites for ATP and chloride in the N-terminal region, affected by mutations linked to epileptic encephalopathy.
A new faculty position in cardiac arrhythmia in the greater Vancouver area.
sfu.ca/content/dam/...
Come join our local arrhythmia community.
