@pmresearch-uhn
The Princess Margaret Cancer Centre is Canada’s largest integrated cancer research, teaching, and treatment centre, one of the top cancer research centres in the world and is one of the University Health Network’s six research institutes.
Our new study @uhnresearch.ca introduces 65 best practice recommendations to support primary care providers in delivering clear, patient‑centred breast cancer screening, developed with meaningful patient partnership and in collaboration with @wchospital.bsky.social:
bmjopen.bmj.com/content/16/2...
New research from @pmresearch-uhn.bsky.social shows why some rare cancers with certain BRAF gene mutations don’t respond to targeted drugs. By studying tumour response, scientists are examining new treatment combos that could offer patients more options.
🔗: www.uhnresearch.ca/news/linking...
Congratulations to our Senior Scientist Dr. Daniel De Carvalho on receiving the 2026 Luminary Honoree, Next-Gen Early Detection & AI Dx Track at the PMWC - Precision Medicine World Conference!
www.linkedin.com/posts/daniel...
Our study, led by Drs. Alex Vitkin and Michael Singh, shows why small scatterers, commonly found in biological tissues, preserve linear light polarization better than circular polarization, potentially improving optical cancer‑detection tools:
onlinelibrary.wiley.com/doi/epdf/10....
@uhnresearch.ca
Former PM patient Melissa T. also shared her family’s experience with cancer and the hope that early detection can bring.
📺 Watch last week’s livestream & Melissa’s story:
youtube.com/live/XmOp9iY...
We were honoured to welcome the Honourable Marjorie Michel, Minister of Health, for the announcement of a $41M+ investment in cancer prevention and early diagnosis research, supported by CIHR and partners.
🔗 CIHR announcement: www.canada.ca/en/institute...
How does the body generate high‑quality immune responses? Our study shows acetylcholine, and the pathways that control it, raise the bar for B cell competition in lymph nodes, selecting for the best performing B cells that produce the strongest antibodies.
rdcu.be/e5smC
@uhnresearch.ca @uhn.ca
Graphic with project name and details. Photo is of Dr. Chan wearing a lab coat with a shirt and tie on a white background.
Most cancers begin with small DNA changes that build up over time. In up to one in three people over 60, these changes lead to clonal hematopoiesis (CH), a pre-cancerous condition that raises the risk of blood cancers like leukemia, but diabetes medications may help interrupt this process. Backed by $2M from the Terry Fox Research Institute, a research team, led by Dr. Steven Chan, at the Princess Margaret Cancer Centre and Lunenfeld-Tanenbaum Research Institute, is exploring whether GLP-1 receptor agonists can prevent CH from progressing to cancer.
“Funding prevention-focused research like this is critical,” says Dr. Steven Chan. “If we can intervene early, before a pre-cancerous condition becomes a malignancy, we have the potential to spare patients from devastating diagnoses altogether.”
What if diabetes drugs, like Ozempic, could help prevent blood cancer?
Clonal hematopoiesis (CH) affects up to 1 in 3 people over 60 and raises leukemia risk. With $2M from TFRI, Dr. Steven Chan is researching whether GLP-1 drugs can prevent CH progression.
Learn more: tinyurl.com/2st9ynj2
Congratulations to Drs. Steven Chan & Faiyaz Notta on receiving Bringing Biology to Cancer Prevention Team Grant, led by CIHR and partners. We are proud to see their work recognized as part of $41M+ investment in cancer prevention & early diagnosis research.
www.uhnresearch.ca/news/major-b...
Photo is of an ex-ray of a rib cage.
Photo of lead researcher, Dr. Benjamin Lok. He is smiling and wearing a suit and tie.
Photo is of a clear DNA strand.
Photo is an illustration of tumour cells.
ICYMI: Terry Fox-funded researchers at UHN’s Princess Margaret Cancer Centre have identified a new target that could enhance the effectiveness of radiation therapy for small cell lung cancer.
Learn more: tinyurl.com/56j66yyb
@pmresearch-uhn.bsky.social @uhn.ca
Our researchers at @uhn.ca & UofT Pharmacy have developed a platform called LUMI-lab, driven by AI and robotics, to automate and accelerate the design and evaluation of lipid nanoparticles, for delivering mRNA medicine into human cells.
@cellpress.bsky.social:
www.cell.com/cell/fulltex...
Exciting new research in advanced melanoma shows sequencing T-cells can help predict and monitor response to adoptive cell transfer, a treatment using a patient’s own immune cells to attack cancer. @uhnresearch.ca @uhn.ca @oicr.on.ca
doi.org/10.1186/s130...
Our senior scientist Dr. Daniel De Carvalho, who discovered viral mimicry in cancer, is featured in a Nature Biotechnology Q&A.
He shares how transposable elements drive cancer and other dieseases, and why they’re emerging as powerful new therapeutic targets:
www.nature.com/articles/s41...
By making a tiny tweak to the surface lipids of a lipid nanoparticle, a key human protein apolipoprotein E dramatically changes its behavior inside our cells, potentially enabling more effective therapies.
@uhnresearch.ca @uhn.ca
pubs.acs.org/doi/10.1021/...
Our researchers analyzed 1,294 blood samples from 11 cancer types to build a comprehensive atlas of DNA methylation patterns, advancing pan-cancer detection and monitoring through liquid biopsy.
Published in Nature Cancer: www.nature.com/articles/s43...
@uhnresearch.ca @uhn.ca
🎉Congratulations to our Director of Research, Senior Scientist and Staff Physician Dr. Aaron Schimmer on being elected to the Association of American Physicians, for his breakthrough research in AML biology.
@uhn.ca @uhnresearch.ca
Today, on #WomenInScienceDay get inspired from the voices of our female scientists, who not only shape the future of cancer care, but also lead with compassion, care for family, and pursue their ambition with unwavering perseverance. 💛
(5/7) Meet Emily Poulton, a PhD student at @pmresearch-uhn.bsky.social, advancing pancreatic #cancer research.
Emily is committed to pushing scientific boundaries and empowering more youth to pursue their path in STEM.
🔗: www.uhnresearch.ca/news/women-s...
Our new study by Dr. Hansen He and Xin Xu's team reveals that a chemical tag called m6A, found on RNA molecules, can act like a switch for tumour growth. Adding this tag to a gene called CHD9 could slow prostate cancer growth in the laboratory:
www.nature.com/articles/s43...
Close-up illustration of a blue DNA strand. Graphic reads, "Research Highlight: Precision medicine should be first-line treatment for metastatic pancreatic cancer, study finds."
🧬Precision medicine should be first-line treatment for metastatic pancreatic cancer, study finds🧬
This study sheds light on the importance of precision oncology and using genomic sequencing to inform care as early as possible.
Learn more about this critical research▶️ tinyurl.com/2p9mn64v
For #WorldCancerDay, see how a @pmresearch-uhn.bsky.social team developed a gene score to predict survival in myelofibrosis—a rare blood #cancer. Led by Drs. Jessie Medeiros, Andy Zeng, Vikas Gupta, and John Dick, this could help tailor treatment decisions.
🔗: pubmed.ncbi.nlm.nih.gov/41481381/
Today, on World Cancer Day, TeamUHN's Dr. Razq Hakem shares how his family's experience with cancer and loss sparked his journey from Morocco to Toronto to advance research, advocacy and treatment.
Read more:
www.uhnresearch.ca/news/meet-dr...
Today, Dr. Hakem is a Senior Scientist at @pmresearch-uhn.bsky.social, recognized globally for his breakthrough work on BRCA1 and BRCA2 mutations and DNA repair mechanisms. Learn more about his discoveries on this #WorldCancerDay:
www.uhnresearch.ca/news/meet-dr...
@uiccofficial.bsky.social
“Keeping it hidden is dangerous. Being informed can save lives.”
Driven by a family loss, Dr. Razq Hakem @uhn.ca @uhnresearch.ca embarked on a research journey to understand the biology of BRCA mutations in breast and ovarian cancer.
www.youtube.com/watch?v=4yTT...
Our scientists at @uhn.ca Princess Margaret and BC Cancer discovered four new subtypes of Hodgkin lymphoma. One subtype with CSF2RB mutations creates an immune “shield”, but it can be reversed by JAK2 inhibitors, offering new treatment potential.
aacrjournals.org/cancerdiscov...
Read about the latest findings from Canada’s largest #research hospital in @uhn.ca’s Research Spotlight newsletter:
▶️Psilocybin for treatment of #depression
▶️An #AI tool to analyze cardiac activity
▶️ Advancements in #Cancer immunotherapy
+ More
🔗: www.uhnresearch.ca/newsletter/r...
Two very different kinds of innovation were recognized through @uhn.ca’s Mission Excellence Awards: a new direction in cancer research led by Dr. Pamela Ohashi, and HALO, a solution already changing how patients are protected every day.
🔗 Read more: www.uhnresearch.ca/news/researc...
The AACR is pleased to announce the Fellows of the AACR Academy Class of 2026. The Academy honors distinguished scientists whose contributions have propelled significant advances in cancer research and treatment. Learn more: buff.ly/ZZ268R4
#AACRFellows
Congratulations to our Senior Scientist Dr. Pamela Ohashi on being named one of the Fellows of the AACR Academy Class of 2026 🎉.
www.aacr.org/about-the-aa...
@theaacr.bsky.social @uhnresearch.ca @uhn.ca
