This is one of the most interesting developments as it appears that authors are now submitting preprints earlier in the process.
A reminder that our data suggests that the best time to post is approx 1 month prior to journal submission (which ~30% now are).
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory @natimmunol.nature.com
www.nature.com/articles/s41...
Whenever I feel bad about being responsible for wasting money on failed wet lab experiments I think about the collective failure from Novo Nordisk to pay 250 Canadian dollars to protect a key patent. I hope there's more to the story than that, honestly.
💀wtf!?
""
.. the last time they paid the annual maintenance fee on it was 2018! You can even find a letter where their lawyers send a refund request for the 2017 maintenance fee ($250) because Novo apparently wanted some more time to see if they wanted to pay it...
""
www.science.org/content/blog...
It's a good question whether there is HLA dependence or not for this effect in the live vaccine. But if a similar effect exists for the recombinant vaccine using glycoprotein E only, doesn't that decrease the likelihood of seeing HLA dependence? Or maybe I'm too pessimistic 😅
.@slavov-n.bsky.social on cell size vs cell count in the human body.
Lots of white blood cells in number, lots of adipocytes (fat) in volume.
Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
Our fresh and still-steaming Journal of Clinical Investigation preprint is out! 🚀
We explore how T-cell acute lymphoblastic leukemia (T-ALL) exploits inflammatory CXCR3–CXCL10 signaling within the meninges to drive CNS infiltration.
www.jci.org/articles/vie...
I agree!
Oh, I absolutely share your opinion. It sometimes feels as though people know the answer before asking the question. Though it's constructed as multiple rounds of cost/risk analysis yielding the sentiment that "hey, if we find nothing, it's a resource to others".
😅 but I admit that I'm probably super biased here from studying for the PhD at an engineering department, where I was the applicationist (is that a word?). I'm traumatized by the responsibility of proving the applicability of a method haha.
Idk, maybe there's a young doctor that will use a method created by a physicist and go on to win the Nobel prize! This was the case for Jens Skou, if I get his speech. www.nobelprize.org/uploads/2018...
I don't see biologists or computational folks generating an abundance of tools as a bad thing.
But it could also be collective delusion for all I know 🙈
If every single field in academia is fundamentally a pyramid scheme with the most renowned individuals at the top. Proposing a method seems more likely to generate a new field, in my opinion, compared to proposing an interesting application using a method others are already experts on.
A very interesting read. I wonder how one could replicate this in other autoimmune disorders. www.nature.com/articles/s41...
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Super interesting how conflated the ABC and DN nomenclatures are in B cell biology. Wouldn't it make sense to pick a different acronym for age-associated B cells, and atypical B cells? And "atypical" seems risky to use as models in immunology can become outdated as paradigms shift, no?
Sunday reading. I aspire to write something like this for T cells one day. www.cell.com/immunity/ful...
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
Me as a PhD student:"I hate how useful this is".
Me as a Postdoc: "I LOVE HOW USEFUL THIS IS".
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1
Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. In this essay: (1) why blog, (2) what to blog about, (3) how to get started, and (4) using AI. https://doi.org/10.59350/bqnfd-7p249 🧪
Double negative T cells can act as professional APCs capable of tolerance induction? How fascinating - I'm picturing a western stand-off between two T cells (both equipped with granzymes btw) unwilling to let go of the other!
