Jonathan Kipnis

Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Brain Borders and CNS Trafficking:
Graeme F. Woodworth, Jonathan Kipnis, and Michael John Mitchel will address this topic in a plenary session at the AACR Special Conference on Brain Cancer (March 23-25, 2026; Philadelphia). Learn more:
buff.ly/CAwsGw8
#AACRbrain26 @jonykipnis.bsky.social

Join us Sep 5-12, 2026 in Venice at the Neuroscience School of Advanced Studies for a course on Integrated Brain-Body Neuroscience featuring world-class speakers @mcalpinelab.bsky.social @jonykipnis.bsky.social @scottrussophd.bsky.social Jessica Able, Jens Brüning, Ivan de Araujo & Kara Marshall.

Researchers led by Drs. Pavle Boskovic, @jonykipnis.bsky.social, and Marco Colonna present amyloid-β-specific engineered CD4+ CAR-T as an approach to directly target sites of pathology for Alzheimer’s disease.

📘 @pnas.org
🔖 https://bit.ly/4aGMCv8

@biorxivpreprint.bsky.social A framework for reparative CAR T engineering in the CNS @idoamitlab.bsky.social @weizmanninstitute.bsky.social @jonykipnis.bsky.social @washumedicine.bsky.social
www.biorxiv.org/content/10.6...

Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease @pnas.org @jonykipnis.bsky.social
www.pnas.org/doi/10.1073/...

First proof-of-concept for engineered T cells as a potential treatment for Alzheimer's disease
pnas.org/doi/10.1073/...

Placebo effect influences vaccine responses - Nature Medicine A randomized trial provides direct human evidence that the placebo effect can shape humoral immunity, showing that reward-related brain activity correlates with vaccine-induced antibody production and opening new avenues for treating many medical conditions.

A new trial provides direct human evidence that the #placeboeffect can shape humoral #immunity and vaccine responses, opening new avenues for biomedical research. News & Views from Jonathan Kipnis & colleagues
https://www.nature.com/articles/s41591-025-04168-7

Brain food on our brain drainage system to help keep you healthy, with @jonykipnis.bsky.social
erictopol.substack.com/p/how-our-br...

Thank you, Dimitrios! 🙏

Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏

How Our Brain Drains Its Waste Products Particular Relevance to Sleep, Alzheimer's Disease and Immune Surveillance

How Our Brain Drains Its Waste Products
and its relevance to our sleep quality and risk of neurodegenerative diseases
A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles
erictopol.substack.com/p/how-our-br...

Smyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/...

🎥 See video summary: youtu.be/FsM6ontxHEI

My top 10 books for 2025

Resolving the mysteries of brain clearance and immune surveillance This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interacti...

How do the metabolic waste products get cleared from our brain? And how does this process intersect with the brain's immune system?
An exceptional review by
@jonykipnis.bsky.social
and colleagues
cell.com/neuron/fullt...

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...

#Neuroinflammation #Alzheimers

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...

#Neuroinflammation #Alzheimers

Look Up! ✨

The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!

#WashU #northernlights #AuroraBorealis

We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis

The Booker shortlist honors authors 'in total command' of their craft The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.

The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.

Some thoughts on meningeal mast cells inspired by Xinzhong Dong and @jonykipnis.bsky.social recent (and AWESOME) papers. Lead: @fakesamir.bsky.social

www.cell.com/trends/immun...

📅 Save the Date: Oxford 2026 Glymphatic Research Symposium!

• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow

Looking forward to seeing you there! 🧠

#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

We are all in this shit… 🤦‍♂️

🙏🙏🙏

Thank you for inviting me back!

In his “Neuroimmunology” lecture, @jonykipnis.bsky.social (@washumedicine.bsky.social) questioned what makes the CNS “immune privileged” if its antigens reach T cells via lymphatics and meningeal APCs—reshaping how we think about brain-immune interactions. #AAIcourses

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...