Matt Foster

🤯🤯🤯🤯

Yeah I’ve wondered that since pST seems to ID more than pSTY. Nice to see you in the wild on bsky. Where next?

I see the $200m+ funding for the program on their site but haven’t done a deep dive into current awards.

The mass range of tandem mass spectra can be categorized into three main regions. For glycopeptides, the lower mass range contains mainly oxonium ions, the middle range contains mainly peptide fragments, and the high range contains charge-reduced fragments. All regions contain valuable fragment ion information, but they can only be simultaneously accessed by breaking the 5–10–15 rule.

MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics.

A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social

1/10

Never disappointed when I go to #ushupo , always a great conference

Seems like you could just get one of those cheap usb microscopes mounted on a stand.

Another awesome #USHUPO in the books. @ucdproteomics.bsky.social is already planning the tour of “Better Call Saul” filming locations for next year in Albuquerque.

Were you at #USHUPO2026 and saw Ben @proteomicsnews.bsky.social and Renã Robinson with Natalie Clark @nmclark2.bsky.social for a LIVE recording of #THEProteomicsShow? Well, I wasn't either, but we now we can bathe our ears in this audio. Find it wherever you find podcasts. anchor.fm/theproteomic...

Quick proteomics question: we want to use an exogenous biotin blocking scavenger for a TurboID experiment. We tried Biolock but is very inconsistent in our hands. Does anyone have another suggestion?

If you are in STL for #USHUPO2026 next week, #THEProteomicsShow is gonna be *LIVE* Monday night at 6:30pm. We've done this a few times now and its always a blast. I can't wait to hear Ben @proteomicsnews.bsky.social and Renã Robinson... and a guest picked immediately before! (volunteers needed!)

9 billion?

So you don't need a Claude AI subscription and can use tokens?

In what disease is Hp (perhaps) lowest?

Plastic jug of colon prep filled with 3L of water

Here’s your Golytely challenge right here

They gave you food afterwards? I’m sure Gen Z will invent “the GoLYTELY challenge” and they’ll be ok.

BoxCar + FAIMS. That's a thing?

Another plasma enrichment methodology. I'm not a huge fan of high-throughput approaches that require a dry down and reconstitution step, but this seems like the type of approach that is destined for commercialization.

Stories from the scientist who changed how we visualize proteins - Nature Reviews Chemistry Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D stru...

www.nature.com/articles/s41...

@benneely.com was the one who taught me about Jane Richardson, the woman who developed ribbon diagram visualization for the 3D structure of proteins! 👩‍🔬🧪🍝🧬💻

Most of my issues were caused by my ORCID being associated with a separate MyNCBI login. Make sure it is populated in your profile before proceeding too far.

Long read proteomics, eh @proteomicsnews.bsky.social? What’s that?

Thought of you when I was using the self checkout and got flagged for putting my Cheerios and reusable bag into the bagging area at the same time. When they cleared me, there was an overhead video of my “maneuver”. Are they using AI to prevent shoplifting?

We can automate data transfer, file conversion and processing in Spectronaut, so that is usually the next step. Then we’re looking at TIC in htrms converter and IDs, XIC extraction width, etc.

If it’s a multi-day study, sometimes targeted extraction in Skyline to look at rt stability, mass accuracy and peptide intensity. Quick and dirty is just to look at file sizes, which often alerts to a bad sample or gradual loss in ion current. 1/2

Ooh that's an idea. I'm missing ASMS but looking for another conference for late summer/early fall.

24 h live stream with callers

My lazy recipe is to cut the leaves cross-wise, stuff them in an instant pot with smoked pork necks or hocks, add some water and red pepper flakes and cook for ~45-60 min. Sometimes I’ll add sugar after they are cooked to sweeten but the molasses is a good tip.

Also you have become the clickbait....

Wow you weren’t kidding 🤯.

Easy peasy