Signal Transduction and Targeted Therapy

An overview of the molecular mechanisms driving #OrganFibrosis across diverse tissues, the key signaling pathways, the therapeutic strategies for mitigating or reversing #Fibrotic progression and relevant #ClinicalTrials.

#OpenAccess: doi.org/10.1038/s413...

An overview of the molecular #Pathogenesis of #Osteoarthritis, detailing the signaling pathways involved and highlighting emerging therapeutic strategies that ameliorate both #CartilageDegradation and clinical manifestations of OA.

#OpenAccess: doi.org/10.1038/s413...

Researchers @roswellpark.bsky.social show that the #Exocyst complex mediates fungal-induced IL-33 release from #Cancer cells, identifying a novel secretory mechanism that links fungal-induced immune signaling to #TumorMicroenvironment modulation.

#OpenAccess: doi.org/10.1038/s413...

Presenting an #iPSC-derived multi-#Organoid platform for NF1-mutant #BreastCancer that enables personalized PK-PD guided therapy providing a high-fidelity model for optimizing treatment regimens for complex genetic profiles.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.

#OpenAccess: doi.org/10.1038/s413...

📣 #ESMOGynae26: From laboratory discovery to clinical application, we invite you to contribute to a programme built around scientific excellence and clinical impact.
⏰ Share your research by 31 March 2026

🔗 https://ow.ly/bAAX50YrNnv
#esmomeetings

📣 #ESMOBreast26: Collaborations between experts of different countries and areas of expertise, excellent networking opportunities and the latest science and education.
⏰Register by 8 April for advantageous fees.

🔗 https://ow.ly/GbBk50YrNVY

#esmomeetings

SMBE 2026 Workshop Genomic History Inference Strategies Tournament kickoff June 28

SMBE 2026 Workshop: Genomic History Inference Strategies Tournament (GHIST) kickoff

🗓️ June 28

🔗 smbe2026.org/programme

#SMBE2026

Prenatal prednisone exposure promotes #MASLD in offspring via #GR-HDAC3-mediated #Serpina3c suppression, activating the #Chymase-AngII-AT1R axis to disrupt lipid metabolism, marking #Serpina3c as a critical #TherapeuticTarget.

#STTT #OpenAccess: doi.org/10.1038/s413...

Exogenous #EBNA1 promotes #ImmunotherapyResistance by enhancing #ADAR1 translation via the IGF2BP3/EIF4G1 complex, suppressing #Interferon signaling and #ImmuneResponse in #EBV-associated cancers.

#STTT #OpenAccess: doi.org/10.1038/s413...

The giant E3 ligase #RNF213 serves as a master regulator of B-cell biology while its deficiency impairs PIK3/PIP3-mediated AKT-mTOR signaling and #MitochondrialRemodeling to disrupt B-cell development and #HumoralImmunity.

#OpenAccess: doi.org/10.1038/s413...

Enhancing KLF15 expression in cardiomyocytes via a dCas9VPR-mediated transcriptional activation system prevents pathological remodeling and #Fibrosis, thereby establishing it as a critical regulator and #TherapeuticTarget in #HeartFailure.

#STTT #OpenAccess: doi.org/10.1038/s413...

Thromboxane A2 receptor activation in dendritic cells protects against #Sepsis by inhibiting S100a8/a9- mediated neutrophil infiltration and #SystemicInflammation, underscoring its potential as a #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

Scientists reveal PKCη as a driver of #TNBC #metastasis by suppressing Hippo signaling & activating YAP, while a uORF-encoded peptide degrades PKCη, highlighting a novel therapeutic vulnerability in aggressive #BreastCancer.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This #STTT study reveals that cholesterol interacts with the spike protein's palmitoylated C-rich region to enhance #SARSCoV2 docking and fusion, highlighting the interaction as a potent #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

📣 All accepted Proffered Paper, Mini Oral, Poster and ePoster abstracts for #ESMORareCancers26 are now online!
Dive into the latest research advancing sarcoma and rare cancers care.

🔗 https://ow.ly/GQI450Yp3SR

#esmomeetings

Researchers show dual-target CD19/CD22 #CARTTherapy plus ASCT achieves durable survival in #TP53-mutated r/r aggressive #BNHL, offering curative potential with consistent long-term safety and paving the way for next-gen #immunotherapies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Researchers introduce NApt8-3, a pan-coronavirus #DNAaptamer that targets the nucleocapsid protein to inhibit #NLRP3-mediated pulmonary #Inflammation, providing a programmable platform against emerging coronaviral infections.

#OpenAccess: doi.org/10.1038/s413...

Scientists map RNA modifications across #multiomics, revealing how genetic variants & PTMs converge to regulate cell fate & disease, with RMzyme offering a resource to explore RMPs as #biomarkers & therapeutic targets. #AcuteMyeloidLeukemia

#OpenAccess #STTT: doi.org/10.1038/s413...

This study identified VV261, an orally bioavailable nucleoside clinical prodrug, as a potent anti-#Chikungunya candidate that inhibits viral replication, significantly reducing viral loads and #Inflammation.

#OpenAccess: doi.org/10.1038/s413...

This study presents BiRDS, a DNA-based miR-22 #nanoplatform that penetrates the #retina via a minimally invasive route, suppresses pathological angiogenesis, remodels vessels, protects neurons, & preserves vision by inhibiting Wnt/β-catenin signaling.

#STTT: doi.org/10.1038/s413...

Enhance your skills in interventional cardiology through dedicated Coronary, Structural tracks and workshops at the #EAPCI26 Summit.

Register today to join us for this inaugural event: https://bit.ly/4q3o5oz

#EAPCI

Rodich on How Oncologists Can Discuss Integrative Medicine for Breast Cancer | OncLive Lillian Rodich, MSPAS, MPH, highlights ways that medical oncologists can counsel patients with breast cancer about integrative medicine modalities.

WATCH: Lillian Rodich, MSPAS, MPH, highlights ways that medical oncologists can counsel patients with breast cancer about integrative medicine modalities. @mskcancercenter.bsky.social #MBCC2026 #bcsm #oncology
www.onclive.com/view/rodich-...

The featured video from #GU26 is now available, the Keynote Lecture by Eliezer M. Van Allen, MD, “Reimagining Cancer Research and Care in the Age of Artificial Intelligence.”

Watch: https://bit.ly/47nKDtE

A randomized, double-blind phase 2b trial shows that #Bofanglutide dose-dependently reduces body weight & improves metabolism in overweight or #Obese Chinese adults, exhibiting a tolerable safety profile. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

This study reveals FUS as a key driver of fibrotic signaling in #IdiopathicPulmonaryFibrosis, with #antisense therapy (ION363) reducing profibrotic gene programs & improving patient-derived lung models, highlighting FUS as a promising therapeutic target.

#STTT: doi.org/10.1038/s413...

This multicenter, randomized, double-blind trial demonstrates that Tongxinluo capsule + standard #Statin therapy increases minimum fibrous cap thickness and reduces lipid arc in #AcuteCoronarySyndrome patients.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers combine #TDDFT and docking to design theranostic probes for #AlzheimersDisease, showing aromatic delocalization and IAF tagging enhance optical response and selective binding to BACE1, #ADAM10, and neprilysin.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This study employs immunogenic mapping to validate a #TrivalentVaccine strategy providing broad protection against #Sarbecoviruses, offering a scalable framework for pan-virus immunity and future #Pandemic preparedness.

#STTT #OpenAccess: doi.org/10.1038/s413...