Poul Sørensen

Immune reset and immune retune: approaching cure? - Nature Reviews Rheumatology The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is...

Immune reset and immune retune: approaching cure? www.nature.com/articles/s41... #immunetolerance #cure

All set for an exciting day at Biocapital Europe in Amsterdam #Inverna #BioCapital2026 #Biotech #RNA #SpliceModulation #Neurodegeneration #ParkinsonsDisease #HuntingtonsDisease #PrecisionMedicine #BiotechInvesting #Partnering

Huntington’s disease is the best investment in neuroscience today Huntington’s disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. W…

Huntington’s disease is the best investment in neuroscience today www.sciencedirect.com/science/arti...
#Huntingtons #Neuroscience #Investment

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/...

#BreakingNews

DBV Technologies Announces Positive Topline Results from Phase 3 VITESSE Trial of VIASKIN® #PeanutPatch in Peanut Allergic Children Aged 4-7 Years

Read the full press release here:
dbv-technologies.com/press_releas...

#FoodAllergy #FoodAllergies #FoodAllergyResearch #PeanutAllergy

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice | Science Translational Medicine www.science.org/doi/10.1126/... 🧪

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress | Nature Neuroscience Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins—like the dementia- and ALS-associated protein TDP-43—mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the fai

Neuronal aging leads to mislocated splicing proteins and unchecked stress. Aged neurons lose RNA-binding proteins. PMID:40456907, Nat Neurosci 2025, @NatureNeuro https://doi.org/10.1038/s41593-025-01952-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Women have supercharged immune systems and we now know why Being born with two X chromosomes brings a host of health benefits, and recognising this could lead to personalised medical treatments for men and women

Me and a few leading colleagues discuss female-specific immune systems in health and disease. By @starrevartan.bsky.social in @newscientist.com www.newscientist.com/article/2501...

Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions - Nature Reviews Gastroenterology & Hepatology | Elena Kotsiliti As immune tolerance is trending now, have a look at this Review on 'Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions' by Ludvig M. Sollid that was published...

Nice review on "Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions" and happy to see one of my companies Allero Therapeutics highlighted

#autoimmune #antigenspecific #immunetolerance #celiacdisease

www.linkedin.com/posts/elenak...

FT: Arsenal 4-1 Tottenham

What colour is North London? And who is Eberechi Eze?

Six points clear at the top and seven points clear of Manchester City.

And we’re just getting started…

Thoughts on the win?

Novel Novartis Malaria Drug Shows Promise to Become New Asset Against Resistant Strains Phase 3 results for the Novartis malaria drug “GanLum” show it was comparable to the standard of care and led to cure rates that top the threshold recommended by the World Health Organization. If approved, this new combination drug would become the first novel malaria therapy in more than 25 years.

Novel Novartis Malaria Drug Shows Promise to Become New Asset Against Resistant Strains
https://medcitynews.com/2025/11/novartis-malaria-ganaplacide-lumefantrine-ganlum-drug-resistance-infectious-disease-nvs/

This year’s #NobelPrize celebrates breakthroughs in immune tolerance. Curious how it shapes #immunotherapy? Join us in Aarhus on Nov 27 for the annual Aarhus Immunotherapy Symposium with a stellar lineup of speakers ! conferences.au.dk/ais

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪

Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.

Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris www.science.org/doi/10.1126/...

Inverna Therapeutics announces the formation of its Scientific Advisory Board consisting of world-renowned leaders in RNA therapeutics and neurodegenerative research | Inverna Therapeutics Inverna Therapeutics is delighted to announce the formation of our new Scientific Advisory Board (SAB)🚀 We welcome world-renowned leaders in RNA therapeutics and neurodegenerative research to advance...

Exciting news from Inverna ! 🎉

www.linkedin.com/posts/invern...

#invernatherapeutics #mjff #grant #parkinsonsdisease #lrrk2 #biotech #startup #neuroscience #innovation | Inverna Therapeutics 🎉 Exciting news from Inverna Therapeutics! 🚀 We’re honored to announce that Inverna has been awarded a grant from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) as part of the LRRK2 Inv...

Big news today! 🎉
#MJFF #RNAtherapeutics #Parkinsondisease #RNAsplicingmodulation #Pseudoexon #Innovation

Extremely well deserved !
#immunetolerance

Huntington's Breakthrough May Not Be The Success It Seems, Expert Cautions Time will tell.

Huntington's Breakthrough May Not Be The Success It Seems, Expert Cautions #Science #HealthandMedicine #Neurology #HuntingtonsDisease #MedicalResearch

Nice to see the RNA splicing modulation area developing - keep an eye on @invernatx.com and their more precise and rationally designed oligonucleotide based approach

Nature: Cancelling mRNA studies is the highest irresponsibility

go.nature.com/3HDx4wD

cc Jay Bhattacharya

Christian Norgaard signs for Arsenal We’re delighted to announce that the Denmark international midfielder has joined us from Brentford

NORGAARD SIGNS!

www.arsenal.com/news/christi...

Changes in the gut that lead to an immune “scar” could be the cause of ongoing celiac disease symptoms www.nature.com/articles/s41...

What a night, what a performance from this far from 100% team, one of the great European nights at the Emirates.

Declan Rice has produced two of the greatest free kicks you'll ever see at this level, and we 100% deserved that third goal too.

Incredible. This team deserves so much love. #arsenal

'This is shameful': Trump sows animosity and mistrust abroad, degrading Americans in the process Rufus Gifford, former U.S. ambassador to Denmark, talks with Rachel Maddow about the animosity and mistrust Donald Trump is sowing among even allied nations, and the shock of betrayal people around th...

So grateful to share a bit of my experience with @maddow.msnbc.com last night. Thanks so much for having me.

www.msnbc.com/rachel-maddo...

Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner. https://www.biorxiv.org/content/10.1101/2025.03.25.645315v1

Denmark hits back at ‘tone’ of US vice-president’s criticism over Greenland ‘This is not how you talk to your close allies,’ says Danish foreign minister Lars Løkke Rasmussen Denmark has hit back against JD Vance’s comments that Copenhagen has not done enough for Greenland. The US vice-president made his remark on Friday during a trip to the Pituffik space base in north-western Greenland, viewed by both Copenhagen and Nuuk as a provocation. Continue reading...

Denmark hits back at ‘tone’ of US vice-president’s criticism over Greenland

Indeed bad news for we beer and cheese lovers - better for wine aficionados...

#bioeuropespring #rnasplicingmodulation #pseudoexons | Mads Aaboe Jensen, MSc, PhD Poul Sørensen, CEO, is presenting Inverna’s platform for RNA splicing modulation at BIO-Europe Spring 2025 in Milan. #BioEuropeSpring #RNASplicingModulation…

Great pitching Inverna and our novel RNA splicing modulation platform at the BIO Europe Spring Startup Spotlight competition ! www.linkedin.com/posts/mads-a...
#RNAtherapeutics #Splicingmodulation #pseudoexon #innovation @invernatx.com

Allero Therapeutics BV on LinkedIn: Sanofi iDEA-iTECH Awards - Europe We are very excited to share that Allero is a winner of the prestigious Sanofi IDEA-TECH Awards 2024! We are very much looking forward to the year of…

Exciting times for Allero Therapeutics !
www.linkedin.com/posts/allero...
#immunotherapy #innovation #inversevaccine

Preventive cancer vaccines deliver tumor antigens or neoantigens, so that the immune system will attack tumor cells.

A new generation of cancer-preventing vaccines could wipe out tumors before they form.

Learn more on #WorldCancerDay: https://scim.ag/4gk8Qmo