Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis This cohort study explores survival and recurrence outcomes of the AMBITION protocol (single-dose liposomal amphotericin with 2 weeks of fluconazole and flucytosine) vs standard protocol for cryptococ...

Applying AMBITION
(single dose Ampho +14 days of 1200 fluconazole + 100mg/kg flucytosine) cryptococcal meningitis treatment at LA county 🏥:

-Higher completion w/o adverse effect (76% vs 35% in conventional dosing)

-Significantly less pts leaving AMA

#IDSky

jamanetwork.com/journals/jam...

Oh sorry I wasn’t very clear ! HAND stands for HIV-associated neurocognitive disorder. I wasn’t sure if it is correct to say that HTLV-1 is the only one causing CNS disease. HIV does as well in my opinion.

What about HAND ?

A diagram showing screening and randomization.

In a randomized, controlled trial, persons with early syphilis received a single treatment or three treatments with benzathine penicillin G at a dose of 2.4 million units. No benefit was seen with the additional doses. Full trial results: nej.md/3UVCKVZ

#MedSky #IDSky

savehhs.org calling for RFK Jr to resign

1000+ current and former HHS staff speak out:

"Should he decline to resign, we call upon the President and U.S. Congress to appoint a new Sec. of HHS, one whose qualifications and experience ensure that health policy is informed by independent and unbiased peer-reviewed science."

www.savehhs.org

Busting the Myth of “Static vs Cidal”: A Systemic Literature Review We conducted a systematic review of published, randomized, controlled trials to compare the efficacy of bacteriostatic and bactericidal antibiotics. Of 56

it's actually crazy how many myths about antibiotics persist despite either no evidence supporting them or evidence overtly contradicting them e.g.:
- bacteriostatic vs bactericidal is essentially made up when it comes to clinical context:
academic.oup.com/cid/article/...