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Jim Janetka

@janetka20

Medicinal chemist interested in cancer and infectious disease (Fimbrion and WashU). Kinase, protease, GPCR, PDE and lectin inhibitor drug discovery. Antibacterial, antiviral, anthelmintic, anti-parasitic. Small molecule, peptide and carbohydrate.

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Latest posts by Jim Janetka @janetka20

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09.03.2026 01:46 πŸ‘ 2914 πŸ” 1709 πŸ’¬ 198 πŸ“Œ 69
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Why was this story on the front page of the UK’s Daily Telegraph β€” but NOT America’s leading newspapers?

07.03.2026 12:04 πŸ‘ 6284 πŸ” 3437 πŸ’¬ 568 πŸ“Œ 263
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

07.03.2026 01:59 πŸ‘ 680 πŸ” 416 πŸ’¬ 19 πŸ“Œ 60
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And this is all he had to replace Noem.

06.03.2026 21:15 πŸ‘ 11739 πŸ” 4330 πŸ’¬ 2440 πŸ“Œ 651
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I am frankly more concerned about the apathy of the American public and even more importantly the lack of leadership in the Democratic Party.

This is not a dress rehearsal. Every single American must speak out against this Facist administration.

06.03.2026 13:40 πŸ‘ 20226 πŸ” 7900 πŸ’¬ 1087 πŸ“Œ 510

This is insane

04.03.2026 17:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
An announcement that the Senate voted to reauthroize the SBIR/STTR program.

An announcement that the Senate voted to reauthroize the SBIR/STTR program.

The Senate has (finally) voted to reauthorize the small business SBIR/STTR program.

Not reauthorized yet, but this was likely the biggest hurdle.

04.03.2026 01:55 πŸ‘ 96 πŸ” 27 πŸ’¬ 1 πŸ“Œ 1
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Seems to be the pattern…

28.02.2026 23:19 πŸ‘ 16648 πŸ” 5056 πŸ’¬ 443 πŸ“Œ 189
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US-Israeli strike on girls' school kills at least 85 students, Iran's judiciary says At least 85 students have been killed in US-Israeli strikes that hit an Iranian girls' school in Hormozgan province, Iran's judiciary said on Saturday. Washington has not commented on the reported str...

We killed 85 schoolgirls. We are not the good guys.

28.02.2026 16:00 πŸ‘ 17024 πŸ” 6535 πŸ’¬ 469 πŸ“Œ 549

This is why it's not enough for Congress to just appropriate funds to scientific agencies. How the funds are or are not spent and when they are spent needs to be enforced.

The administration is playing games with our taxpayer dollars, when they should be going towards scientific innovation.

27.02.2026 18:32 πŸ‘ 41 πŸ” 28 πŸ’¬ 1 πŸ“Œ 0

"The woman who directly named Trump in her abuse allegation claimed that around 1983, when she was around 13 yrs old, Epstein introduced her to Trump who subsequently forced her head down to his exposed penis which she subsequently bit. In response, Trump punched her in the head and kicked her out."

24.02.2026 15:34 πŸ‘ 3160 πŸ” 1461 πŸ’¬ 163 πŸ“Œ 82
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πŸ‘‡πŸ‘‡

23.02.2026 02:25 πŸ‘ 962 πŸ” 513 πŸ’¬ 35 πŸ“Œ 21
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It’s not leadership anymore it’s a circus, and everyone’s fighting for center ring.

23.02.2026 13:05 πŸ‘ 13491 πŸ” 4211 πŸ’¬ 1363 πŸ“Œ 468
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cdn.factcheck.org/UploadedFile...

The link above shows what the MAGA Trump supporters put in our White House and EXACTLY what the MAGA GOP House and Senate are protecting.

Trump raped a 13-year-old child multiple times, hit her when she said stop, and threatened the lives of her family. A SCUMBAG

22.02.2026 19:40 πŸ‘ 296 πŸ” 144 πŸ’¬ 21 πŸ“Œ 9

Hopefully it increases exponentially in April and May after council meetings

17.02.2026 17:18 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ‘‡πŸ‘‡πŸ‘‡πŸ‘‡

14.02.2026 00:59 πŸ‘ 12516 πŸ” 5305 πŸ’¬ 392 πŸ“Œ 246
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πŸ‘€ πŸ‘€

12.02.2026 23:57 πŸ‘ 18978 πŸ” 9214 πŸ’¬ 847 πŸ“Œ 589

Trump is in the Epstein files over ONE MILLION TIMES which means they redacted his name at least 962,000 times.

10.02.2026 20:34 πŸ‘ 1289 πŸ” 353 πŸ’¬ 55 πŸ“Œ 22

Good morning. The President of the United States was in the middle of the most serious child sex trafficking ring of the last quarter century.

He is referenced not a dozen times in the case files. Not 100 times. Not 1,000 times. He’s referenced 38,000 times.

08.02.2026 19:50 πŸ‘ 38089 πŸ” 14353 πŸ’¬ 1381 πŸ“Œ 743
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Please share. πŸ’”

25.01.2026 04:46 πŸ‘ 13487 πŸ” 8388 πŸ’¬ 298 πŸ“Œ 401

I have been thinking all day about the number of times unarmed Black people were killed by police on the pretext that their cell phone looked like a gun. And people would say β€œoh but you just donβ€˜t know what the truth is.” Well here it is.

24.01.2026 21:30 πŸ‘ 972 πŸ” 320 πŸ’¬ 8 πŸ“Œ 3
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The man was confronted because he was filming them - he had his phone in hand - the gun was holstered
They tackled beat & murdered him in ICE cold blood & then they fucking LIE

24.01.2026 18:59 πŸ‘ 34 πŸ” 17 πŸ’¬ 1 πŸ“Œ 2

Does it have anything about reinstating the sbir program?

20.01.2026 19:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This is very revealing about intent and response.

We have to continue to appreciate that a major goal is intimidation and they see steps up to murder as acceptable tactics.

10.01.2026 20:29 πŸ‘ 30 πŸ” 18 πŸ’¬ 1 πŸ“Œ 1
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πŸ“’ CARB-X Novel Chemistry for AMR Challenge!
CARB-X is seeking applications for novel chemistry plans against known #AMR targets. The aim is to unlock innovative starting points for therapeutics to address drug-resistant bacterial infections. #IDSky #ChemSky πŸ§ͺ
πŸ”— bit.ly/4blmsyN

08.01.2026 14:00 πŸ‘ 4 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0

@bostonu.bsky.social
@bulaw.bsky.social
@asprgov.bsky.social
@niaidnews.bsky.social
@wellcometrust.bsky.social
@gatesfoundation.bsky.social
@dzif.bsky.social

08.01.2026 14:00 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Right after RenΓ©e Good’s disgusting murder, a ICE goon was filmed kicking her memorial candles.
Absolutely vile.

08.01.2026 12:03 πŸ‘ 18467 πŸ” 8519 πŸ’¬ 1591 πŸ“Œ 1580
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Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?

Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)

www.nature.com/articles/s41...

30.10.2025 10:27 πŸ‘ 87 πŸ” 34 πŸ’¬ 3 πŸ“Œ 5
Submit your research to JCM's Special Series, "Diagnostic Testing for Mycobacteria."

Submit your research to JCM's Special Series, "Diagnostic Testing for Mycobacteria."

Tuberculosis (TB) remains one of the world’s leading infectious killers, and NTM infections are rising. #JClinMicro invites submissions to our "Diagnostic Testing for Mycobacteria" series. πŸ“„ Share your research now β†’ asm.social/2B6

16.09.2025 14:18 πŸ‘ 9 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
NOT-OD-25-155: New Application Structure for NIH-Funded International Collaborations NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: New Application Structure for NIH-Funded International Collaborations NOT-OD-25-155. NIH

New NIH Notice about International Collaborations

grants.nih.gov/grants/guide...

1/3

12.09.2025 21:34 πŸ‘ 40 πŸ” 25 πŸ’¬ 3 πŸ“Œ 3