RyanLab_TCD

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting papers 🧪:

I) The immunometabolic topography of cellular organization in TB

II) The human antibacterial factor APOL3 couples lysosomal damage to mtDNA efflux and type I IFN induction.

STING–NF-κB signaling builds an influenza spillover barrier Influenza pandemics are often traced back to the spillover of avian influenza A viruses (IAVs) to humans. However, barriers against IAV transmission remain elusive. We demonstrated human stimulator of...

Increasing evidence that STING has functions beyond DNA viruses. A new study reports that STING restricts influenza infection, independently of IFN. This work complements prior studies that STING prevents infection with diverse RNA viruses.
www.science.org/doi/10.1126/...

Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and #immunometabolism in inflammatory macrophages 🧪
www.biorxiv.org/content/10.6...

Glutathione is critical for NK cell-mediated immunity Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...

Glutathione is critical for NK cell-mediated immunity #immunometabolism www.cell.com/cell-reports...

@biomednews.bsky.social

Figure 9: Anti-influenza mechanism of action of cis-aco. DOI: 10.1038/s44321-026-00379-8.

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

Hi Erik, I just wanted to follow up on being included in the science feed? Thank you!

Hi Dani, I wrote to be included in the science feed some time ago but my science communication posts with all the requested information but they don't appear here yet. Would you mind adding me to the list? Thank you!

Graphical abstract from https://doi.org/10.1016/j.immuni.2026.01.003

Graphical abstract from https://doi.org/10.1016/j.molcel.2026.01.010

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪

biomed.news/bims-imicid/...

Incl.

I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation

II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...

Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity!

www.nature.com/articles/s41...

Lokiarchaeon CBASS ❤️

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"For everything you do, there will be a last time that you do it."-William B. Irvine

@biorxivpreprint.bsky.social RNP+Sm+ defines a high-risk, refractory, myeloid-driven lupus endotype characterised by activity linked hyperferritinemia that likely requires therapies directed at the underlying IFN and myeloid-centred pathways @ucl.ac.uk
www.biorxiv.org/content/10.6...

It's an incredible piece of work

Cooperative Architecture of Mitochondrial Proteome Homeostasis Mitochondria are semi-autonomous organelles whose generation and maintenance demand precise expression, processing, and assembly of >1,000 proteins encoded across two genomes. To explore this cooperat...

Cooperative Architecture of Mitochondrial Proteome Homeostasis 🧪
www.medrxiv.org/content/10.6...

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and pathogen escape 🧪 #immunometabolism
www.researchsquare.com/article/rs-7...

Yeah both the authors and peer reviewers have clearly seemed to miss the point....

I'm not sure, often evaluation of the central dogma comes from a position of misunderstanding or superficial evaluation of the key tenet. The main point (that has yet to be violated) is that information does not flow backward from protein.

Chrysanthi Moschandrea and I have developed a new conceptual framework for understanding the role of metabolism in cancer, which we term metabolic permissiveness. We are eager to hear your thoughts on this topic.

genesdev.cshlp.org/content/earl...

🔊Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Interesting findings🧪:

I) Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...

Single Cell Glucose Uptake Assays: A Cautionary Tale Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...

A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
www.nature.com/articles/s41...
@natcomms.nature.com

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
www.nature.com/articles/s41...
@natcomms.nature.com

Would be great!

Immunometabolism researchers are meeting in Newcastle on 16-17 April!

Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26

Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45

Looking forward to speaking at this #UKimmunomet26 conference in Newcastle. Make sure to check it out! @britsocimm.bsky.social

www.immunology.org/events/fuell...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com

Why does mitochondrial disease still take ~8 years to diagnose?
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...