Giuseppe Di Caprio

Smart microscopy: adaptive microscope control to improve the way we see life - npj Imaging npj Imaging - Smart microscopy: adaptive microscope control to improve the way we see life

Another interesting review on #SmartMicroscopy. 🔬https://www.nature.com/articles/s44303-026-00145-y#Sec1

Mucosal vaccination in mice provides protection from diverse respiratory threats Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...

Mucosal vaccination in mice provides protection from diverse respiratory threats | Science www.science.org/doi/10.1126/...

GitHub - imaging-formats/bffile: Modern Bio-Formats wrapper with clean lazy Python API Modern Bio-Formats wrapper with clean lazy Python API - imaging-formats/bffile

Rewrote my Python bioformats wrapper (from aicsimageio/bioio) as a standalone package:

- fully bootstrapped Java setup (just pip install)
- lazy, repeatably-indexable Array object
- fully spec-compliant OME-Zarr group obj.
- xarray/dask exports

github.com/imaging-form...
v0.0.rc1 on PyPI

OpenClaw AI chatbots are running amok — these scientists are listening in Artificial-intelligence agents have their own social-media platform and are publishing AI-generated research papers on their own preprint server.

OpenClaw AI chatbots are running amok — these scientists are listening in www.nature.com/articles/d41...

I just passed the Life in the UK test! Now I can forget everything 😊 (Jane Seymour who?)

CellSAM: a foundation model for cell segmentation - Nature Methods CellSAM uses an object detector, CellFinder, to detect cells and prompt the Segment Anything Model (SAM) to generate segmentations. This universal model achieves human-level performance across a range...

Just read the new CellSAM paper, a tool for cell segmentation across diverse imaging modalities, no retraining needed. Looking forward to trying it in our lab. 🔬
www.nature.com/articles/s41...

Make sure to follow our department’s brand-new Bluesky account! Exciting updates coming soon. @biomedeng-strath.bsky.social

When we physicists need a manual just to look like socially functional humans at conferences 😂 apparently there’s an article for that #Networking101 #LifeofSheldon
doi.org/10.1088/2058...
via @ioppublishing.bsky.social

Why the world must wake up to China’s science leadership The nation’s next generation of scientists and technologists will shape the coming decades.

Why the world must wake up to China’s science leadership www.nature.com/articles/d41...

Had a great time at the SIPTA Forum in Huairou Science City, Beijing, together with colleagues from Imperial College, Tsinghua University, Peking University, and the Chinese Academy of Sciences. I was also fortunate to visit collaborators on the Tsinghua campus and at the Institute of Automation.

🚨Only 2 more weeks to apply for our fully-funded PhD position @york.ac.uk! Want to pioneer a blood test for dementia, detect single molecules & spend time in industry with
@ei-science.bsky.social?! Apply by 4th Dec:
tinyurl.com/yt36p9tx
It doesn't get any more EXCITING! 🔬🩸🧪

I’m pleased to share that I’ve been awarded support from the Royal Society–CNR International Exchanges scheme for a project with colleagues in Italy. We’ll combine advanced optical imaging and AI to better understand how cancer cells store fats using label-free 3D microscopy.

What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature

I’m not sure about coffee, but I dump used tea leaves into my office plants, and they seem to like it.

What makes PhD students happy? Good supervision Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

www.nature.com/articles/d41...

Daily briefing: People with cancer lived longer if they’d had a COVID-19 vaccine mRNA vaccines seem to ‘rev up’ the immune system to boost immunotherapy. Plus, a rare meteorite has been recovered from the Moon and the mysterious transition between wakefulness and sleep.

www.nature.com/articles/d41...

A beautiful piece of work from @ruixuan3.bsky.social and @supgokul.bsky.social presenting a light-based slicing method using a photosensitive hydrogel to image large biological samples layer by layer, preserving fine structure for full 3D reconstructions.

We’re excited to welcome Grant McClure, John Selkirk, Ben Polwart, and Robert Barry, who are undertaking their 5th-year Industrial Partnership Project on the OpenFlexure Microscope, an open-source, 3D-printed laboratory microscope designed to make high-quality microscopy accessible worldwide.

Say Hi to Nicola👋🏻🔬, our shiny new Nikon microscope. Already the most popular member of the lab... Sorry everyone else 😅

A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.

www.nature.com/articles/s41...

Strathclyde named Scottish University of the Year and Runner-Up UK University of the Year by The Times and Sunday Times www.strath.ac.uk/whystrathcly...

The rising danger of AI-generated images in nanomaterials science and what we can do about it - Nature Nanotechnology Generative AI has made it trivial to generate fake microscopy images that are indistinguishable from real images, even for experts. As researchers in nanoscience, it is time for us to face this realit...

A bit of a terroristic view. Synthetic data isn’t all bad, it has been shown to improve classification algorithms.

P.S. We’ve got a hopefully interesting contribution to this field coming shortly. 📝 Stay tuned.
www.nature.com/articles/s41...

Two Strathclyde Uni researchers receive grants worth more than £1.8m each The two researchers have received grants worth more than £1.8m each

Big congrats to Lewis @lemackz.bsky.social and Pablo! @unistrathclyde.bsky.social www.heraldscotland.com/news/2547411...

Indeed! @biomedeng25.bsky.social

IEEE is everywhere. 🤓 #IsleofKerrera

Figure legend: Categories and capabilities of smart microscopy systems integrating real-time image analysis and feedback control. Top: Smart microscopy workflows can be classified based on the driving logic behind decision-making: Event-driven (reacting to rare biological events), Outcome-driven (using feedback-control to steer biological systems toward a desired state), Quality-driven (optimizing signal quality or imaging metrics), and Information-driven (guided by models that predict which measurements/perturbations will yield the most informative data). Middle: Central feedback loop between the microscope and an image analysis system, which continuously exchanges images and commands to guide acquisition dynamically. Bottom: Key control actions enabled by smart microscopy: adjusting imaging modality (e.g. switching from brightfield to fluorescence, adjusting sampling rate), repositioning the field of view (e.g. tracking, drift correction), optimizing acquisition settings (e.g. adaptive optics), and performing photomanipulation (e.g. FRAP, ablation, optogenetics).

🔬🧠 Our paper on smart microscopy & the issue of interoperability! www.biorxiv.org/content/10.1... LONG THREAD WARNING: Smart microscopy uses real-time image analysis to automatically guide the acquisition or perturbation of the sample (closed feedback-control loop). Many applications exist:

rBio: Reasoning Model Trained on Virtual Cell Simulations Scientists can ask complex biological questions in plain language and get predictions about gene interactions.

Intrigued to know more about rBio, a new AI model from CZI that uses virtual cell models to explore biology in silico.
chanzuckerberg.com/blog/rbio-re...

Smart Microscopy: Current Implementations and a Roadmap for Interoperability Smart microscopy is transforming life sciences by automating experimental imaging workflows and enabling real-time adaptation based on feedback from images and other data streams. This shift increases...

www.biorxiv.org/content/10.1...

We just got a new toy 🔬🤓

GrantNet would be fairer, since he came up with it. 😁