Lisa Gennai

Here it is!
Thanks to @fcaredda.bsky.social (who did the heavy lifting) , @lgennai.bsky.social and Andrea Pagnani. It has been a really fun collaboration.

journals.plos.org/ploscompbiol...

😄

Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can levera...

Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well.
Together with @fcaredda.bsky.social @lgennai.bsky.social and bluesky-absent Andrea Pagnani.

www.biorxiv.org/content/10.1...

Excited to be here!