Dalila

Retinopathy Risk With Long-Term HCQ Treatment Detailed in Meta-Analysis Eye damage remains uncommon after 15 years, but certain factors increase the risk

About one in 18 patients taking hydroxychloroquine for 15 years develop retinal damage, a new meta-analysis indicated.
https://www.medpagetoday.com/rheumatology/lupus/120228

“A Change is Gonna Come” to Treatment of Lupus Nephritis: A Review

bit.ly/43X14f5

We don't know why women are more likely to develop autoimmune diseases than men.

@bcellsrosser.bsky.social & her group at UCL are looking into the role of sex & gender in immunity.

Recently, the group examined differences in immune cell responses between men & women with #lupus: shorturl.at/XBRRe

Rare Kidney Diseases

'Rare Kidney Diseases' is a peer-reviewed, #OpenAccess journal dedicated to advancing clinical and translational knowledge in glomerular, autoimmune, and genetic kidney diseases across all age groups. bit.ly/3ZG9FA5 @glomcon.org #NephSky @kronbichlerlab.bsky.social

Weekly recap in ACR Journals banner - Arthritis Care & Research cover

Posted this week in Arthritis Care & Research

Algorithm to identify prevalence of SLE in Australia
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Estimating minimal important change for pain & function outcomes in guided exercise for hip OA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

🦋 Great to learn more about Lupus Ontario’s work at their AG Meeting today covering awareness, education, fundraising, support, & research.

⭐️ Dr Ian Bruce (Belfast/Manchester) gave an excellent talk on #lupus damage: when should damage be considered if lupus activity can start long bf diagnosis?

SLEuro that’s a wrap! It’s been a great few days of learning and sharing, including four posters from the @mikeehrenstein.bsky.social lab and a great oral presentation on STRATIFY lupus from @shipam.bsky.social 👏

Research Article

Individual and Socioecological Resilience in Childhood-Onset Systemic Lupus Erythematosus: Associations With Patient Characteristics and Psychosocial Patient-Reported Outcomes

📖 www.jrheum.org/cgi/content/...
@sickkidsto.bsky.social

#Lupus #Pediatric #Resilience

TWEAK/Fn14 signaling drives oxidative cardiac injury in systemic lupus erythematosus: Evidence from patient biomarker studies, lupus mouse models, and cardiomyocyte assays. A graphical abstract

Patients with SLE can quietly accumulate cardiovascular damage. New study reveals the TWEAK/Fn14 axis as key molecular link driving oxidative myocardial injury, even before symptoms appear. Targeting this pathway may enable early cardiac protection
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Protein signatures elevated in patients with SLE. (A) Correlation matrix displaying intercorrelation between SOMAScan 1.1K array protein measurements positively altered in patients with SLE vs HC with Mann–Whitney adjusted P<0.10, AUC>0.5. The direction of protein levels in SLE vs HC, 21-IFNGS high patients, severe patients as determined by SELENA-SLEDAI or SDI, and protein signature-positive participants are displayed in the color bar on the right. (B) Bar chart displaying proportion of cohort negative for all four signatures (5/87 patients – 5.7%) or positive for at least one signature (2 SD from HC mean used as threshold; 82/87 patients – 94.3%). (C) Scatter box plots displaying elevation of protein signatures in IFNGS-high and IFNGS-low SLE vs HC, Mann–Whitney U test used to measure significance of differences between groups. 21- IFNGS, interferon 21-gene signature

Integrated multiomic blood profiling identified an immune cell priming signature linked to renal involvement and long-term organ damage in SLE, outperforming conventional clinical measures in identifying patients at high risk

A&R
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

💜

Over 1000 people aged under 18 have kidney disease in the UK. It's not just an older person's disease – that's a myth! People of all ages are living with it.
Get clued up on the facts here: www.worldkidneyday.co.uk/check/
#WorldKidneyDay #KidneysMatter

💙💙😍

Urinary Biomarkers May Predict Long-Term Outcomes in Lupus Nephritis A new study examined whether urinary biomarkers could predict future kidney complications in individuals with lupus nephritis (LN).

A new study suggests certain urinary biomarkers could serve as helpful indicators of ongoing kidney inflammation in people with #lupus nephritis. Read more on the study:

Lupus Access to Care: Why Diagnosis, Trust & Equity Still Matter YouTube video by Lupus Canada

📽️ Great series “Let’s Talk Lupus: A Pathway to Progress” from Lupus Canada bringing together leading lupus experts to discuss access to care and the importance of mental health in lupus. An important conversation driving progress. #LupusAwareness #HealthcareAccess #Lupus

youtu.be/uGpBRht-yzM?...

Join us on March 18 for our free national Lupus & You education event focusing on what you need to know to protect your kidneys, including the importance of early detection, what labs to watch, and treatment options.

Register today! buff.ly/XeIt8tV

#NationalKidneyMonth #KidneyMonth

“It’s Rare Disease Day!” with the Rare Disease Day hand logo and the website” The background is a blue and purple gradient.

🌍 It’s #RareDiseaseDay 2026! 💜

Today we stand with the 300 million people living with a rare disease. Together, we’re showing our colours, raising awareness, and inspiring change by talking about what equity means to us.

👉 Read more: https://go.rarediseaseday.org/NEWS

Kidney Care UK graphic featuring cartoon kidneys and text for Rare Disease Day on 28 February 2026. It states, 'Did you know around 70 in 100,000 people have a rare kidney condition?'

This #RareDiseaseDay, we're bringing light to rarely spoken about kidney diseases. We understand the difficulty in diagnosis & finding information.

Visit our rare kidney conditions webpage 👉 www.kidneycareuk.org/rare-kidney

Here's the truth 🔦

There are usually no symptoms of kidney disease in the early stages.

It may only be discovered if you have a blood or urine test for another reason.

Find out the symptoms> www.worldkidneyday.co.uk/check #KidneysMatter #WorldKidneyDay

Peer-based self-management interventions may prove beneficial for adult African American women with systemic lupus erythematosus A new study found peer-mentoring interventions on self-reported disease activity, symptom severity, and flare frequency among adult African American women with systemic lupus erythematosus (SLE) may…

New study finds programs that use peer support to help manage #lupus benefit adult African American women with the disease. Read the study:

1/16
In lupus nephritis (LN), “activity” gets the spotlight—but chronic scarring often decides the long game. So: which chronicity score best predicts outcomes—NIH Chronicity Index (NIH-CI) or the Mayo Clinic Chronicity Score (MCCS)?
buff.ly/tvebmPZ

Our March 2026 issue is live!

Including research in individuals at risk of developing arthritis, real-world data on anifrolumab in #SLE, #cardiovascular risk in #APS, and childhood-onset Sjögren's disease, plus much more! thelancet.com/journals/lan... #Rheumsky

Cover by @emma-cheng.bsky.social

Living with RA, Axial SpA, Lupus, Psoriasis or PsA? These conditions can affect every part of life including intimacy and sexual health - yet this is rarely talked about.

(1/3)

Table: Practical Tips for Interpreting HCQ Whole Blood Levels in Clinics

Toward Optimal Dosing in SLE: The Case for Hydroxychloroquine Blood Level Monitoring
doi.org/10.1002/acr....

Table: Practical Tips for Interpreting HCQ Whole Blood Levels in Clinics

Michigan man’s lupus diagnosis took ‘a while’— and he’s not alone Data from the National Lupus Foundation found 63% of people with lupus surveyed were incorrectly diagnosed.

Six months ago, Angel Garcia was diagnosed with lupus, a chronic autoimmune disease that affects thousands of people in Michigan each year. Garcia said he knew something was wrong before the diagnosis came.

CAR-T therapy provides relief for children with autoimmune diseases Nature - Symptoms and organ damage abated in young children and teenagers whose conditions had resisted other treatments.

CAR-T cell therapy seems to have reset the immune system and eased severe symptoms in eight children and adolescents with autoimmune disorders

go.nature.com/4rsFlFx

Beyond the Symptoms: Navigating Lupus, Race and the Struggle for Health Equity Madonna Grant, a Black woman with lupus, shares her journey through delayed diagnosis, bias, and systemic inequities. Her story highlights the urgent need for inclusive research, culturally competent ...

#Lupus #LivedExperience Madonna Grant's Lupus Story: My journey to diagnosis taught me two powerful truths: that young people can be seriously ill, and that persistence — especially from those who love us — can be lifesaving.
@springernature.com

communities.springernature.com/posts/beyond...

🌍 Join us on 18 March 2026 for the WORD Day Webinar!

Our expert speakers will share valuable perspectives on early recognition and the importance of specialised paediatric treatment.

Join the webinar here 👉 https://pulse.ly/syi0xshhxu

#WORDDay2026

Lupus nephritis is a type of immune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus that can affect up to 60% of patients with this condition http://dlvr.it/TQyLby
#NephSky

Exercise rewires the brain — boosting the body’s endurance Nature - The more mice exercise, the more connections form between some neurons in their brains, study finds.

This is your sign to go for the run

go.nature.com/4avd21B