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Britton Sauerbrei

@brittonsauerbrei

Neurophysiologist working on motor control and neural population dynamics. Assistant Prof. at the Case Western Reserve University School of Medicine. https://sauerbreilab.org/

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15.11.2024
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Latest posts by Britton Sauerbrei @brittonsauerbrei

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This one focuses on modern art, not interdisciplinary connections, but it’s a classic (and, I think, graphically excellent).

06.03.2026 03:35 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

05.03.2026 09:47 πŸ‘ 106 πŸ” 40 πŸ’¬ 6 πŸ“Œ 4
fly circuit diagram

fly circuit diagram

When a fly lands on your arm, how does your nervous system decide where to swat?

By reconstructing tactile axons in a Drosophila connectome, we found a leg somatotopic map and downstream circuits that sample the map to initiate targeted grooming

Led by Leila Elabbady, PhD

doi.org/10.64898/202...

03.03.2026 19:20 πŸ‘ 38 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0

Using our bee-tracking drone, we discovered that honey bees 🐝 have highly precise and individual routes. Now published at @currentbiology.bsky.social : doi.org/10.1016/j.cu...

16.02.2026 16:22 πŸ‘ 255 πŸ” 118 πŸ’¬ 6 πŸ“Œ 9

A remarkable discovery: motor sequences in zebra finch song are generated intrinsically within HVC. Beautiful!

14.02.2026 18:05 πŸ‘ 9 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Feedback control of random networks as a model of flexible motor cortical dynamics across tasks Kalidindi and Crevecoeur develop a computational framework linking feedback-controlled networks to limb dynamics. They demonstrate that optimal control of fixed network reproduces key motor cortical d...

Paper is out by @harikalidindi.bsky.social : feedback control model of neural population activity
www.cell.com/cell-reports...

13.02.2026 12:14 πŸ‘ 31 πŸ” 8 πŸ’¬ 0 πŸ“Œ 4
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πŸ”¬πŸ§  Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

12.02.2026 01:32 πŸ‘ 98 πŸ” 35 πŸ’¬ 2 πŸ“Œ 2
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Some scientists used to think that birds are just kind of stupid. In the 1960s, the neuroanatomist Harvey Karten’s research into avian neural circuits changed how the field viewed bird intelligence. www.quantamagazine.org/intelligence...

13.02.2026 16:46 πŸ‘ 25 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Primate dexterous hand movements are controlled by functionally distinct premotoneuronal systems Distinct spinal and cortical pathways coordinate muscle synergies and fine control to support primate dexterous hand movements.

Our paper is out in Science Advances!
What makes primate hands so dexterous?
We show that evolutionarily distinct spinal and cortical pathways work together to balance stability and flexibility, supporting remarkable primate hand control.
www.science.org/doi/10.1126/...

12.02.2026 00:40 πŸ‘ 35 πŸ” 17 πŸ’¬ 4 πŸ“Œ 1
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New paper alert! 🚨

We found that the brain's compass is remarkably stable at two scales

1️⃣ the system maintains its internal organization for weeks
2️⃣ It "remembers" its orientation for weeks, even after a single visit

This may be key to how the brain aligns its other maps.

Paper: rdcu.be/e3waP

11.02.2026 17:52 πŸ‘ 198 πŸ” 69 πŸ’¬ 5 πŸ“Œ 7

From Chand: β€œof potential interest”. Our lab’s first dataset! Tian and friends used Neuropixels to record from 7,500 units across DLPFC and PMd to show how contextual decision making (specifically, XOR computation) occurs and how this differs by location in DLPFC and between areas.

10.02.2026 19:15 πŸ‘ 20 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

This is a catastrophic unforced error.

It was quite something to hear @ohsunews.bsky.social President Shereef Elnahal equate the shambolic lies of fringe groups (β€œothers”) with the heartfelt & credible testimony of the scientists & veterinarians in his employ.

β€œTeammates” don’t support rivals.

10.02.2026 04:24 πŸ‘ 29 πŸ” 18 πŸ’¬ 3 πŸ“Œ 0

β€œA sanctuary is not a strategy. It is a capitulation to fear and the political pressure that ignores scientific reality”

Well said @vincentcostaphd.bsky.social

10.02.2026 02:55 πŸ‘ 43 πŸ” 15 πŸ’¬ 1 πŸ“Œ 1
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Neuro’s ark: Understanding fast foraging with star-nosed moles β€œMacArthur genius” Kenneth Catania outlined the physiology behind the moles’ stellar foraging skills two decades ago. Next, he wants to better characterize their food-seeking behavior.

Kenneth Catania spoke with @thetransmitter.bsky.social about how the specialized snout of the star-nosed mole allows for high-speed foraging and underscores the importance of studying behavior alongside anatomy.

By Lauren Schneider

#neuroskyence

www.thetransmitter.org/neuros-ark/n...

04.02.2026 14:57 πŸ‘ 29 πŸ” 7 πŸ’¬ 0 πŸ“Œ 4

We have updated this preprint. I think the deeper dive that @mkashefi.bsky.social has done on the 'shift' condition-independent signal is particularly interesting. www.biorxiv.org/content/10.1...

03.02.2026 00:28 πŸ‘ 13 πŸ” 2 πŸ’¬ 3 πŸ“Œ 0

Beautiful work - congrats!!!

21.01.2026 16:42 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A synaptic locus of song learning Learning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)

Where does learning through imitation happen in the brain?

In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

21.01.2026 16:39 πŸ‘ 71 πŸ” 26 πŸ’¬ 5 πŸ“Œ 7
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Dynamic engagement of the motor cortex in controlling movement Neural circuits do not contribute equally or continuously to behavior. In mice, the motor cortex can be essential or dispensable for movement in different contexts, but how it is dynamically recruited...

Very excited to share a new preprint - my first paper in the @mikeeconomo.bsky.social labβ€―where weβ€―asked when and why the motor cortex is recruited for movement control:πŸ§ πŸ‘‡https://www.biorxiv.org/content/10.64898/2026.01.13.699314v1

15.01.2026 15:27 πŸ‘ 21 πŸ” 10 πŸ’¬ 2 πŸ“Œ 3
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The lab comedians wanted some natural light. @eric-kirk.bsky.social

14.01.2026 23:27 πŸ‘ 11 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The Neural Control and Computation Lab is seeking a skilled part-time software engineer in Toronto to lead the development of ATHENA (Automatically Tracking Hands Expertly with No Annotations), our open-source, Python-based toolbox for 3D markerless tracking!

www.yorku.ca/health/resea...

13.01.2026 14:52 πŸ‘ 17 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0

Congrats @danielavallentin.bsky.social happy to see this out in @currentbiology.bsky.social

12.01.2026 22:08 πŸ‘ 28 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

Thanks, Juan!

09.01.2026 15:32 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social β€˜s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

08.01.2026 19:59 πŸ‘ 132 πŸ” 41 πŸ’¬ 10 πŸ“Œ 2
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Neuronal calcium spikes enable vector inversion in the Drosophila brain In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...

www.cell.com/cell/fulltex...

We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -

06.01.2026 16:35 πŸ‘ 59 πŸ” 28 πŸ’¬ 1 πŸ“Œ 3
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Here's another, showing raw voltage throughout the dendritic tree, the virtual reality location of the animal, the mouse-eye view, and the voltage at the neuron's soma.

04.01.2026 06:17 πŸ‘ 26 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0
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What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

04.01.2026 06:17 πŸ‘ 130 πŸ” 50 πŸ’¬ 3 πŸ“Œ 2
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Ruskin on generative AI.

31.12.2025 01:40 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Glad to see this out - very cool.

28.12.2025 02:53 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Routing of task-relevant information in mouse PPC during continuous visuomotor control Posterior Parietal Cortex (PPC) exhibits tuning to many variables, including strong representations of visual information, movement, and behavioral biases. Whether PPC communicates all these variables...

Very nice paper by Matt Kaufman's group: "Routing of task-relevant information in mouse PPC during continuous visuomotor control". www.biorxiv.org/content/10.6...

28.12.2025 02:48 πŸ‘ 11 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0

This would be a disaster for science and medicine.

23.12.2025 01:54 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0