Stern-Ginossar Lab

N1-Methylpseudouridine directly modulates translation dynamics Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.

Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬
Full paper : rdcu.be/eY5gx

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Structure-guided discovery of viral proteins that inhibit host immunity Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...

Join our RNA Mediated Regulation of Immunity conference! Register until January 28th and access two conferences for the price of one, including Non-Coding RNA Biology. keysym.us/KSRNAImmune25 #KSRNAImmune25 #RNA #regulatoryRNA #immunology #immunity @sginossarlab.bsky.social

We're excited to announce the 2025 Nucleic Acid Tx meeting - on 5/2/25 at the Weizmann.
Great speakers from academia/industry. Co-org with
@sginossarlab.bsky.social @schraga.bsky.social Yaniv Erlich and Yogev Debbi.

Abstract submission/free reg. link: bit.ly/3ODdRer