Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning PLATO, a high-resolution and high-throughput spatial mass spectrometry proteomics platform, identifies distinct tumor subtypes and key dysregulated proteins in human breast cancer.

Tools
"Here, we present parallel-flow projection and transfer learning across omics data (PLATO), an integrated framework combining microfluidics with deep learning to enable high-resolution mapping of thousands of proteins in whole tissue sections."
www.cell.com/cell/fulltex...

That moment when you remember that you are one of the few vertebrates that don't have #gdTcells.

Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis Restricted access of Kupffer cells to the bloodstream in newborns is linked to increased systemic bacterial infections and higher mortality.

In this work, they demonstrate that the migration of KCs into liver sinusoids depended on macrophage migration inhibitory factor and its receptor CD74 but occurred independently of the microbiome.

www.science.org/doi/10.1126/...

Yesterday, Paul Kubes gave an outstanding lecture at our institute @unibern.bsky.social . It was refreshing to see research where, for once, the microbiota did not take center stage. Congratulations to the talented scientists behind this impressive work, now published in Science Immunology.

Please add me to the list, thank you very much! =)