Abid Hussaini

Coherent dynamics of thalamic head-direction neurons irrespective of input While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...

🚨New preprint alert!

The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.

Some explanation 🧵👇 1/13

www.biorxiv.org/content/10.1...

1/
🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

Event structure sculpts neural population dynamics in the lateral entorhinal cortex Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)

👉 www.science.org/doi/10.1126/...

OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...

Applications are now open! 3-week courses: Comp Neuro and Deep Learning. 2-week courses: NeuroAI and Comp Tools for Climate Science.

🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨

Get your application in early to be a student or teaching assistant for this year’s courses!

Applications are due Sunday, March 23.

Apply & learn more: neuromatch.io/courses/

#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪

Join us at #COSYNE2025 to explore recent advancements in large-scale training and analysis of brain data! 🧠🟦

We also made a starter pack with (most of) our speakers: go.bsky.app/Ss6RaEF

NeuroAcademy A 3-week summer enrichment program for high school students with the option of 1 of 2 sessions: July 7 - July 25, 2025 or July 28 - August 15, 2025.

@burkeneurosci.bsky.social is excited to offer the NeuroAcademy program for high school students starting in July 2025. This 3-week, hands-on training course will introduce students to fundamental biological based neuroscience at the molecular and cellular levels.

Scientists Just Found A New Alzheimer's Warning Sign A new study suggested that not getting enough REM sleep can be an early warning sign of Alzheimer's disease. Here's what a neurologist wants you to know.

"The researchers discovered that people who took longer to get to the REM stage of sleep were more likely to have biomarkers of Alzheimer’s disease."

Sleep should be sacred, you get the best sleep, apart from the tips in this article, in darkness and silence.

#sleep #brainhealth #alzheimers

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans - Nature Communications The hippocampus is thought to encode the content of stimuli, but how it does so is unknown. The authors show that when hippocampal spiking variability tracks the abstract building blocks of individual...

*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...

Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease INTRODUCTION Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across d...

New work from our postdoc Elouise Koops just got published: #locuscoeruleus metabolism is elevated in preclinical Alzheimer’s disease, and provides resilience against cognitive decline! In collaboration with Joyita Dutta (UMass) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

go.bsky.app/LdtUYZS

I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.

Tell me who I haven’t found yet

I made a systems neuroscience starter pack, focused on experimentalists who study the brain at the level of populations of neurons!

Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭

go.bsky.app/UiqX7ry

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of APP NL-G-F mice https://www.biorxiv.org/content/10.1101/2024.11.26.624990v1 The progressive accumulation of amyloid beta (A{beta}) pathology in the brain has been associated wi

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of APP NL-G-F mice https://www.biorxiv.org/content/10.1101/2024.11.26.624990v1

Pleased to announce that Shuzo Sakata and I are recruiting for a PhD student to work on hippocampal-thalamic interactions in sleep using Neuropixels ephys: details in the link. Deadline Monday 6th January 2025. Come and work in beautiful Scotland!

www.gla.ac.uk/postgraduate...

Someone had to do it! I created a starter pack for #Alzheimer’s #dementia #ADRD researchers on Bluesky. Please let me know who I left out! Hoping more and more of us will join Bluesky

go.bsky.app/22DpUEy

Big update to the Aging Research starter pack. Many new folks joining every day, so challenging to keep up. Related starter packs by @brunetlab.bsky.social and @paigeonthebrain.bsky.social‬. Networks are built by self-reinforced expansion and amplification.
go.bsky.app/PcreQSa

ertorres.bsky.social, Bill Rebeck, and I recently concluded our Research Topic on APOE4-associated heterogeneity in AD. Here’s our editorial summarizing the papers that were published: www.frontiersin.org/journals/agi... Thank you to all the contributors!

Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain - Nature Communications Mapping the nature of multiprotein nanostructures in cellular contexts remains challenging. Here, Kang and Schroeder et al. report multiplexed expansion revealing, a technique which expands proteins a...

Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...

4) - Increased buildup of amyloid-beta protein, but not tau, in some COVID-19 patients, hinting the virus may trigger an immune response involving amyloid.

The findings indicate severe COVID-19 can induce broad brain changes ...

For anyone interested, I wrote this piece recently:

www.thetransmitter.org/sex-differen...

#Alzheimers #womensbrainhealth

#neuroskyence #cognition #psychology

Three presentations from our group at #SfN24 in Chicago. Please consider dropping by!

Positions, Oldenburg Lab Join the lab We are looking for curious, motivated, and talented people from all different backgrounds to join our team at all levels.

Not sure if we've hit critical mass here on bsky yet, but the lab is hiring!

We've gotten some good news grants recently, and now have some funded projects that are looking for people to champion them.

All projects use Holographic Optogenetics to study motor systems.

oldenburglab.com/positions/

Entorhinal grid-like codes for visual space during memory formation

Neat study from Isabelle Wagner's new group:

www.biorxiv.org/content/10.1...

Interested in large scale approaches to large scale spatial navigation?

Come see my talk on our new ManySpaces collaboration: 10/8, 1:30 pm eastern.

Hedgehog spiking logo

OK, my first bsky post is...

Submit your abstracts for the SNUFA spiking neural network conference by this Friday! The conference is free, online and usually has around 700 highly engaged participants. Talks are selected by participant interest.

Please do signal boost this!

snufa.net/2024/

Averaging is a convenient fiction of neuroscience But neurons don’t take averages. This ubiquitous practice hides from us how the brain really works.

some cool news - I've started a regular column at The Transmitter @thetransmitter.bsky.social

First column out now on that most convenient of all the fictions in neuroscience: averaging
thetransmitter.org/neural-codin...

The Center for Alzheimer's Disease Research at Brown University under the new leadership of Bess Frost invites applications from investigators focused on Alzheimer's disease and related dementias for a tenure-track or tenured position. apply.interfolio.com/154858. Join us!!!

🚨I am recruiting PhD students!🚨
(Please re-post this!)

If you are interested in #spatialNavigation, #fMRI, #aging, #virtualReality, #AlzheimersDisease and more, please consider applying to work with me!

IMPORTANT: Please email me prior to applying!

The European honey bee may have originated from eastern Africa. This bee is pictured in Tanzania. Photo: Muhammad Mahdi Karim 12mm long Apis mellifera, Apis mellifera. Pictured in Dar es Salaam, Tanzania. https://en.wikipedia.org/wiki/Honey_bee#/media/File:Apis_mellifera_Tanzania.jpg

Honeybees understand the concept of zero, or "null set", putting them in the same cognitive class as parrots, dolphins and primates in that regard.

What's more interesting to me is HOW WE CAN KNOW THAT.

The experimental design is what I want to focus on: