Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) i...

New link between the gut Microbiome, bile acids and Osteoarthritis :

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling | Science

www.science.org/doi/10.1126/...

Ravie d'avoir présenté nos travaux aux #JFHOD2025.
Un grand merci à Zhan qui a mené ce projet de collaboration avec Biocodex ainsi qu'à Loic, Laura, Rand, @jeremielefevre.bsky.social et @h-sokol.bsky.social

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood Increased serotonin in the gut epithelium is anxiolytic and antidepressive which is mediated through vagal signaling. Maternal selective serotonin reuptake inhibitor exposure is associated with a risk...

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood - Gastroenterology www.gastrojournal.org/article/S001...

Mucosal macrophages govern intestinal regeneration in response to injury. Cancer patients treated with radiotherapy in the abdominal and pelvic cavity develop radiation-induced enteritis, a condition that impairs their quali…

www.sciencedirect.com/science/arti...

Risk of age-related and disease-related complications and mortality in elderly-onset IBD - a population-based study In this nationwide cohort from Israel (Epi-IIRN), we aimed to characterize risks for age-related complications, mortality and IBD-related surgeries in patients with elderly-onset inflammatory bowel di...

www.cghjournal.org/article/S154...

Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease A metagenome-informed metaproteomics approach unravels the interplay between the host, gut microbiome, and diet in animal models as well as in human cohorts and identifies disease biomarkers of dysbio...

Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease: Cell www.cell.com/cell/fulltex...