Luke Norton

We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...

Pleased to share our recent article on the importance (or not!!) of lean mass preservation in patients with obesity participating in weight loss interventions. This was driven by Jeffery Bolte and Annie Smelter, two very talented students in the lab.

Corrected for placebo, 14.4% of patients had a reduction in liver fibrosis with no worsening steatohepatitis 🤔.

The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis - Nature Communications This study identifies transcription factor 7-like 2 (TCF7L2) as a key regulator of hepatic metabolic zonation, and demonstrates that disruption to the transcriptional activity of TCF7L2 exacerbates th...

Please check out our latest manuscript describing the spatial transcriptional function of TCF7L2. Blocking TCF7L2 activity disrupts important zonated pathways (i.e. bile, cholesterol and glutamine metabolism) and predisposes mice to diet induced hepatic fibrosis.

www.nature.com/articles/s41...