bioRxiv SysBio

dAMN: a genome scale neural-mechanistic hybrid model to predict bacterial growth dynamics https://www.biorxiv.org/content/10.64898/2026.03.04.709593v1

Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) https://www.biorxiv.org/content/10.64898/2026.03.04.705181v1

A systemic circadian nicotinic acid riboside (NaR) signal engages the unfolded protein response and adipogenesis via the prefoldin complex https://www.biorxiv.org/content/10.64898/2026.03.04.709493v1

Two Stages of Dynamic Metabolic and Transcriptomic Remodeling During the Adaptation to Caloric Restriction in Male C57BL/6J https://www.biorxiv.org/content/10.64898/2026.03.03.709429v1

An analytical framework for phenotypic selection of fitness-conferring genes https://www.biorxiv.org/content/10.64898/2026.03.03.709325v1

MORPHE: Bridging Image Generation and Spatial Omics for Tissue Synthesis https://www.biorxiv.org/content/10.64898/2026.03.03.709377v1

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise https://www.biorxiv.org/content/10.64898/2026.03.02.705347v1

Exercise modulation of the alternative splicing landscape in human tissues https://www.biorxiv.org/content/10.64898/2026.03.03.704460v1

Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) https://www.biorxiv.org/content/10.64898/2026.03.02.704798v1

Ageing impacts extracellular matrix turnover and remodelling in the kidney https://www.biorxiv.org/content/10.64898/2026.03.02.709057v1

Why Boolean network control tools disagree: a taxonomy of control problems https://www.biorxiv.org/content/10.64898/2026.03.01.703722v1

TGFβ signaling systems are prone to inhibition and ligand competition by coreceptor https://www.biorxiv.org/content/10.64898/2026.03.01.708909v1

STRESS HISTORY ESTABLISHES A TRANSIENT TOLERANT STATE THAT SHAPES ANTIBIOTIC SURVIVAL UPON RESUSCITATION https://www.biorxiv.org/content/10.64898/2026.03.01.708845v1

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium https://www.biorxiv.org/content/10.64898/2026.02.27.702183v1

Comparison of different computational frameworks for metabolic modeling from single-cell transcriptomics data in glioblastoma https://www.biorxiv.org/content/10.64898/2026.02.28.706749v1

AOPGraphExplorer 2.0: An Interactive Graph-Based Platform for Multi-Domain Mechanistic Annotation and Exploration of Adverse Outcome Pathways https://www.biorxiv.org/content/10.64898/2026.02.27.708648v1

Challenges and Opportunities in Single-Sample Network Modeling https://www.biorxiv.org/content/10.64898/2026.02.27.708608v1

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling https://www.biorxiv.org/content/10.64898/2026.02.26.708310v1

A Multispecies, Modality-Agnostic Scalable In Vivo Mosaic Screening Platform for Therapeutic Target Discovery https://www.biorxiv.org/content/10.64898/2026.02.26.708253v1

Single-Cell Spatial Proteomics Uncovers Molecular Interconnectivity among Hallmarks of Aging https://www.biorxiv.org/content/10.64898/2026.02.26.708335v1

Variation of Human Transfer RNA Demand and Supply https://www.biorxiv.org/content/10.64898/2026.02.26.708130v1

Constraint Semantics for Multi-level Organization https://www.biorxiv.org/content/10.64898/2026.02.27.708558v1

The Potential Effect of Vitamin D Supplement on Selected Coagulability Predictors in Vape-Exposed Female Rats https://www.biorxiv.org/content/10.64898/2026.02.25.708056v1

Structural and Metabolic Characterization of Ni(I)-inhibitors Provide a Robust Anti-Methanogenicity Scoring System https://www.biorxiv.org/content/10.64898/2026.02.25.708075v1

Aging under immunosuppression reshapes human immune compartments and lowers clinical alloreactivity after heart transplantation https://www.biorxiv.org/content/10.64898/2026.02.25.681707v1

CellSwarm: LLM-Driven Cell Agents Recapitulate Tumor Microenvironment Dynamics and Sense Indirect Genetic Perturbations https://www.biorxiv.org/content/10.64898/2026.02.25.707926v1

Generalized Morphogenesis Theory: A Flow-Inertia Modeling Framework for Cross-Scale Dynamics of Dissipative Structures https://www.biorxiv.org/content/10.64898/2026.02.23.707312v1

NF-κB transcriptionally enhances p53 accumulation dynamics hampering DNA repair https://www.biorxiv.org/content/10.64898/2026.02.24.707448v1

What microbes want: exploring microbial substrate preferences with the Web of Microbes Agent https://www.biorxiv.org/content/10.64898/2026.02.23.707520v1

Leveraging Twin Information for Inference of Gene Regulatory Networks https://www.biorxiv.org/content/10.64898/2026.02.22.707230v1