Robert Arkowitz

Ribosome Molecular Aging Shapes Translation Dynamics
www.biorxiv.org/content/10.6...

We have a new paper out today from superstar Nora Herzog!

A virus that fluidizes the nucleus to enable replication!

Check it out here:

lnkd.in/e-xV8acK

This was an amazing collaboration with Ian Mohr and Angus Wilson

Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs Bacterial resistance to the vital last-resort antibiotic colistin is an increasing challenge. This study shows that magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher…

In new research, Yu-Ying Phoebe Hsieh, Ian O’Keefe, Ajai Dandekar, Harmit Malik &co reveal how magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher levels of resistance to colistin (a last-resort #antibiotic).
🧪#MicroSky

Comment une levure devient mycose

En élucidant le mécanisme qui rend le champignon microscopique Candida albicans capable de provoquer des mycoses, une équipe du CNRS ouvre la voie à de nouvelles pistes thérapeutiques.

You are finishing your PhD and looking to continue in science?

The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....

Thanks for reposting!

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

RNA-specific local translation is patterned by
condensates for multinucleate cell growth
www.nature.com/articles/s41...

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule The druggability of intrinsically disordered regions.

www.science.org/doi/10.1126/...

The structured hairpin region of the bacterial ESCRT-III protein IM30 orchestrates stress-induced condensate formation

www.biorxiv.org/content/10.6...

Comment une levure devient mycose

En élucidant le mécanisme qui rend le champignon microscopique Candida albicans capable de provoquer des mycoses, une équipe du CNRS ouvre la voie à de nouvelles pistes thérapeutiques.

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations | PNAS Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates indispensable processes such as exocytosis, endocytosis, and actin...

A fascinating look at the frankly bonkers, still-mysterious relationship between master membrane regulator PIP2 and its precursor. Another classic from Min Wu's lab!

What is Mycoprotein? Health Benefits, Nutrition Facts, and Sustainability Explained Whole-food mycelium is a nutrient-dense fungal biomass that delivers complete protein, functional fiber, and measurable cardiometabolic benefits while offering scalable, lower-impact production compar...

Did you know mycoprotein packs nearly as much protein as meat - plus fiber and B vitamins - while helping cut your carbon footprint? 🍄🌍 See why fungi are the future of sustainable nutrition: www.news-medical.net/health/What-... #SustainableProtein #FoodInnovation

Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucos…

"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa"

Nobody can predict what can happen with your work.

www.sciencedirect.com/science/arti...

A lineage-specific selective autophagy receptor module mediates P-body turnover Abdrakhmanov et al. identify a lineage-specific autophagy receptor module that mediates the selective recycling of P-bodies in the liverwort Marchantia polymorpha. The conserved decapping factors EDC4...

www.cell.com/developmenta...

A symbiotic origin of the ribosome? Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

academic.oup.com/pnasnexus/ar...

A conserved archaeal ribosome-associated factor linking bacterial hibernation and eukaryotic energy sensing
www.biorxiv.org/content/10.6...

Single-cell and isoform-specific translational profiling of the mouse brain - Nature Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

www.nature.com/articles/s41...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

www.science.org/doi/10.1126/...

Global genetic rewiring during compensatory evolution in the yeast polarity network - PubMed Functional defects resulting from deleterious mutations can often be restored during evolution by compensatory mutations. Importantly, this process can generate the genetic diversity seen in networks regulating the same biological function in different species. How the options for compensatory evolu …

pubmed.ncbi.nlm.nih.gov/41699154/

Candida auris vacuolar calcium pump mediates fluconazole efflux and resistance evolution - Nature Microbiology The relocalization of the vacuolar calcium pump Cdt1 to the plasma membrane contributes to fluconazole adaptation in Candida auris.

www.nature.com/articles/s41...

Septins associate with AP-3 to support trafficking to the vacuole/lysosome in yeast www.biorxiv.org/content/10.6...

Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi Many plant pathogenic fungi penetrate host surfaces mechanically, using turgor pressure generated by specialized infection cells called appressoria. These appressoria develop semipermeable cell walls ...

www.science.org/doi/10.1126/...

Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.

Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM

Funding cuts could put research into emerging threats to lung health at risk Wildfire smoke, spore-spread fungal diseases and microplastic are all on the rise, even as the US government slashes support for respiratory research and policy.

Funding cuts could put research into emerging threats to lung health at risk www.nature.com/articles/d41...

A small Candida glabrata protein promotes hyphal growth in C. albicans during mixed-species invasive candidiasis C. glabrata is often co-isolated with C. albicans from mixed-species infections. Parnandi et al. show that C. glabrata exports a unique protein, Yhi1, via its mating machinery to promote filamentation...

www.cell.com/current-biol...

Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi Chen et al. identify the natural product butyrolactol A as an inhibitor of the phospholipid flippase Apt1-Cdc50, which it locks in a nonfunctional state. By disrupting membrane homeostasis and enhanci...

www.cell.com/cell/abstrac...

Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage | PNAS The fungus Candida albicans and the Gram-positive bacterium Enterococcus faecalis share mucosal niches in the human body. As opportunistic pathogen...

www.pnas.org/doi/10.1073/...

And this work was done together with Niko Grigorieff, also MRC LMB alumni!

Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth Nature Microbiology - During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of...

Thanks! I assume you are referring to this link, hope it works:

www.nature.com/articles/s41...

www.nature.com/articles/s41...