Soyon Hong

Thank you Erin 💜💜

So great that this paper is finally out! Happy that I was able to contribute to this important study. Congratulations @seppedeschepper.bsky.social, @soyonhonglab.bsky.social, Tim Bartels and all co-authors!

Targeting the gut's immune system could tackle early stages of Parkinson's New research reveals how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice led by scientists at the UK D...

New research has revealed how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice co-led by Dr @soyonhonglab.bsky.social & Dr Tim Bartels @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Our paper is finally out!

We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain

www.nature.com/articles/s41...

🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!

Absolutely thrilled & grateful to be awarded this prestigious ERC grant. None of this would have been possible without the remarkable team in my lab, past & present! Excited for the next steps of this important project.

Very excited and honored to join the Warsaw glia symposium- can’t wait to learn more about and discuss together the beauty and the complexity of glia with the community!

Amazing, Staci!!! 💜

You’re so kind. Thank you ☺️

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace.

Congrats to first author Jonathan Bastos!

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint

💪💪💪 @blurtonjoneslab.bsky.social sooo cool!

Super fascinating!! Congrats, Tomás!!!

#AAICNeuroNext is really fantastic - connecting the world’s ECRs! The whole event is super inspirational - I got goosebumps when I saw how connected this event is , representing and promoting global research

Thanks so much, Malu! You’re so kind

Selina's fundraiser for Alzheimer's Research UK Help Selina wray raise money to support Alzheimer's Research UK

I've #justsponsored Selina Wray, who's fundraising for Alzheimer's Research UK on @JustGiving. Donate now:

www.justgiving.com/page/selina-...

WEBseq share freely

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

Day 2 Session 7 #ImmuneDynamics at #BarrierTissues #gut_brain in #neurodegeneration with Michal Schwartz Soyong Hong Sandro Da Mesquita Elizabeth Bradshaw & Ryan Hobson

Yay Wendy!!! Rockstar 🤩🤩

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

Lipids: Emerging Players of Microglial Biology Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...

Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....

👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...

led by Michael Heneka, published in @natrevimmunol.bsky.social today

(MANY more authors listed and linked below)

Sancerre? 🙋🏻‍♀️

Congratulations!!!!! What beautiful work !!