Sana Nasim

This work advances our understanding of how developmental vascular programs become dysregulated in disease and opens the door to targeted therapies that could improve outcomes for patients with Sturge Weber.

MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations | PNAS Nonsyndromic capillary malformations (CM) are seen predominantly in skin. In Sturge–Weber Syndrome (SWS), CMs occur in the skin, leptomeninges of t...

Now online @pnas.org

Our new publication on the mechanisms driving capillary malformations in Sturge Weber syndrome!!
www.pnas.org/doi/10.1073/...

This work advances our understanding of how developmental vascular programs become dysregulated in disease and opens the door to targeted therapies that could improve outcomes for patients with Sturge Weber.

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

Now online @nature.com!

Want to change the consequences of receptor activation?

Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥

So many new possibilities! 🧪🧠🟦

www.nature.com/articles/s41...

🧵👇

thank you, hao!

These insights deepen our understanding of how blood flow interacts with genetic mutations to drive vascular malformations and open avenues for targeted therapies.

GNAQ p.R183Q Endothelial Cells Fail to Align in Response to Laminar Shear Stress and Exhibit Increased Expression of MAPK, Inflammation, and Cell Adhesion Genes Endothelial cells with the GNAQ p.R183Q mutation do not align properly when exposed to laminar shear stress. Transcriptomic analysis of mutant versus wild type endothelial cells exposed to increasing...

Thrilled to share our new publication in FASEB!

We found that endothelial cells carrying the GNAQ p.R183Q mutation fail to align in response to blood flow. They show heightened activation of MAPK, inflammation, and adhesion pathways, pointing to a disrupted mechanosensory response.

August 22, 2025 Dear Director Bhattacharya: I write to you regarding your plans after the Supreme Court ruling yesterday. As you know, the Supreme Court did allow a stay on the required grant reinstatements based on a controversial jurisdictional issue but also found that the grant termination processes used were likely illegal. I know you are deeply concerned about public trust in NIH. I hope that you understand that proceeding to fail to reinstate or to re-terminate grants that had been found to have been illegally terminated will not increase the public trust in NIH. This would also be substantially damaging to science.

I just sent this email to Director Bhattacharya and am sending him a hard copy by registered mail.

1/14

Why strong mentorship was essential for my career success in science JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors.

Here you go..." Why strong mentorship was essential for my career success in science" JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors. www.nature.com/articles/d41...

Love to see this!!!!!!!!

Congratulations Victor!! Keep moving the endometriosis field forward!

Congratulations Ruth and the team!!!!

two men in suits and ties are waving their hands in a room ALT: two men in suits and ties are waving their hands in a room

NIH BREAKING NEWS NIH BREAKING NEWS

Hearing from multiple sources that an email went out late yesterday afternoon

Effective immediately: Please do not terminate any additional grant projects. Please pull back all grant projects that are in the cue to be terminated.

Some of us MOSAIC scholars (myself included) still haven't even received our official grant termination... These games they're playing with us, & now, "you have the opportunity to write another grant instead of finishing the research work/writing the paper that will get you hired". Thin gruel indeed

Everything seems awful sometimes, but I've met the absolute best folks in the midst of all this chaos.

Case in point: a brilliant new colleague (who asked to remain anonymous) sketched one of Judge Young's more incredulous statements about NIH's anti-DEI policy today:

Huge congratulations, Nate!!!!!!!! So happy for you!!!

Being a first generation university graduate, the impact on a career in science Being in the first generation to access Higher Education (First Gen) is a barrier to academic success. First Gens face difficulties transitioning into, completing, and attaining competitive grades in ...

Very interesting study! I’m also a first generation PhD and graduate, but I fortunately had the parents support and the ability to build networks and connections. Raising awareness about the existing barriers is a great start. #chemsky #education #firstgen

Bioprinted platform for parallelized screening of engineered microtissues in vivo Human engineered tissues hold great promise for therapeutic tissue regeneration and repair. Yet, development of these technologies often stalls at the…

Taking a breath w new paper announcement. Bioprinted platform for parallelized screening of engineered tissue formulations in mice (1/4).
See paper in @cp-cellstemcell.bsky.social here:

www.sciencedirect.com/science/arti...

📢 I'm happy to announce Dr Marcelo Hill from Universidad de la República and Institut Pasteur de Montevideo as the next speaker of the Seminar Series we created to highlight PIs from underrepresented countries in science.

Please join us for this amazing talk!

📅 April 1st, 2025
🕐 1 pm (EST)
📍 Zoom

Don’t just say DEI as if it’s a bad word. Spell it out.

Say diversity, which is the lifeblood of American society & culture & innovation.

Say equity, which a just society should pursue.

Say inclusion, because decent people believe in increasing belonging, not isolating people who are different.

Starter Pack: Collective #CellMigration /Dynamics is growing. Looking at related emergent phenomena eg. #intercallation, dorsal closure or branching #morphogenesis? Reach out! Also modelers, soft-matter physicists & YOUNG scientists etc etc!

go.bsky.app/DLUDYX3
#cellbio #SoftMatterPhysics #science

Could I please be added to this? Thank you!

Can I please be added? Thank you!

Can I please be added to this!? Thank you!

Could I please be added to this group, Julie!? Thank you!

Can I please be added? Thank you!

A quote for 2025!

'Twas the night before grant deadline A scientist's holiday poem

"‘'Twas the night before grant deadline, 7:15.
Many creatures were stirring, thanks to caffeine.
The comments accepted, the references done,
In hopes someone might fund my first R01."

I’d like to be added, please!

Congratulations!!!!