Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...
Great work from post-doctoral fellow @joanzone.bsky.social:
New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation.
doi.org/10.64898/202...
Pervanadate is more than just a phosphatase inhibitor!
Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too.
Link: tinyurl.com/5ype7e2s
Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3
@babrahaminst.bsky.social
I am honored to be selected to give a talk at #ASBMB26 on the work I have done in the @benturklab.bsky.social! We have developed a strategy to selectively activate specific LKB1 substrates. Looking forward to presenting, connecting, and seeing great science at this conference! @asbmb.bsky.social
We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci.
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
Intricate regulation of Src kinases via N-terminal modifications and specific degradation pathways. A novel degradation pathway involving the CUL4A-DDB1-DCAF10 E3 ligase found by Kremer et al. Tanja Bange lab @andrea-musacchio.bsky.social @ispt-proteinterm.bsky.social www.nature.com/articles/s41...
The core facility at Tufts (tucf.org) still does Edman sequencing, and we still use it. Most people now use MS. But if your aim is to unambiguously map the N-terminus and quantities of protein are not limiting, Edman is the way to go. Also less expensive than using a core facility for MS.
Announcement indicating that the next Yale Pharmacology Research in Progress (RIP) talk will be held on Tuesday, November 25, 2025 at 1:00 pm on West Campus in the Advanced Biosciences Center ABC 373. The presenters will be Pauline Pan, a graduate student in the Turk lab, and Nalini Natarajan, a postdoc in the Boggon lab.
Come join us for the Pharmacology RIP talks on Tuesday, November 25th at 1:00 pm!
we just posted our new work on #SRC #kinase led by the superb Prashant Jain 🤩 Inspired by nature, we discover that the length of the catalytic loop and the autophosphorylation site can be engineered to fine-tune downstream pathway activation. 🙏🏻 @oistedu.bsky.social
www.biorxiv.org/content/10.1...
Flyer for Yale Pharmacology's 2025–2026 Alan C. Sartorelli Lecture, presented by Tobias Meyer, PhD. Dr. Meyer will be presenting his work at 4 pm on Thursday, October 16, 2025 in The Anlyan Center (TAC) N107, with a reception to follow from 5-6 pm. Dr. Meyer is the Joseph Hinsey Professor of Cell & Developmental Biology and Professor of Biochemistry & Biophysics at Weill Cornell Medicine. The title of his talk is "Both Structural and Signaling Polarity Mechanisms Direct Cell Migration."
Join us in welcoming our 2025-2026 Alan C. Sartorelli Lectureship speaker, Dr. Tobias Meyer. He will be presenting his work at 4 pm on Thursday, October 16th in The Anlyan Center.
Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Brent Stockwell, PhD will be presenting his work at 12 pm on Thursday, October 9, 2025 in the Brady Auditorium. Dr. Stockwell is the William R. Kenan Jr. Professor & Chair of Biological Sciences and Professor of Chemistry and of Pathology & Cell Biology at Columbia University. The title of his talk is "Drugs, Food, & Metabolism: Ferroptosis as a New Therapeutic Paradigm."
Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker, Dr. Brent Stockwell (brentstockwell.bsky.social). He will be presenting his work at 12 pm on Thursday, October 9th in the Brady Auditorium.
We're hiring new faculty! Looking for talented scientists that are interested in pushing the boundaries of Cell Biology. Please spread the word!
It's in the adopted amendments. Page 8:
www.appropriations.senate.gov/imo/media/do...
Excited to see this paper out in its final form, and huge congrats to first author Ziyuan (Jason) Jiang just a week before his thesis defense. This work has become an invaluable resource in our lab for SHP2 projects, and we hope it resonates with the whole field.
www.nature.com/articles/s41...
Last chance to save $150 and get the latest in protein kinases and phosphorylation at #PrPSRC. Join us in Scottsdale at a gorgeous resort overlooking the mountains. Save your space and register: buff.ly/BvsZmQm
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
Hey folks - last chance to join us at the FASEB SRC on "G Protein-coupled Receptor Kinases and Arrestins" June 22-26, 2025 in Niagara Falls, NY!! events.faseb.org/event/gprk-a...
We present SELPHI 2.0 a machine learning model integrating >40 sequence, omics and structural features to predict kinase-substrate interactions between 420 kinases and 240K phosphosites and improve interpretation of global phosphoproteomics data www.sciencedirect.com/science/arti...
In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.
Very excited to be hosting Michael Greenberg tomorrow for this year's Cooper lecture. If you're local this is not to be missed!
Here is a very informative memo from a large group of legal experts about the legality of equity and inclusion work. Hopefully your institutions are continuing to support equity and inclusion. If they aren't, you might want to share this memo with them. drive.google.com/file/d/129LV...
Another way to put this:
Musk and his twerps have exposed us to pandemics, broken science, stolen all your data, endangered the U.S. payments system, threatened air traffic control, and cut off HIV medication to 20m people in order to save ::checks notes:: 2/10th of a percent of the federal budget.
📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪
Latest Institute research with special guests ⤵️
www.eventbrite.co.uk/e/cellular-s...
BBS-Wide Joint Cultural Foods Social Hour! This Friday :)
Flyer for the Yale Pharmacology Seminar Series. This flyer indicates that Titus Boggon, Ph.D. will be presenting on Thursday, January 23, 2025 in the Brady Auditorium. The title of his talk is "Revisiting RasGAP: New insights from the first GTPase Activating Protein for Ras."
Titus Boggon will be speaking at the next seminar in our 2025 Pharmacology Seminar Series. Join us at 12 pm on Thursday, January 23 in the Brady Auditorium to hear about his exciting work.
Psyched to have Mike Yaffe visiting Yale Pharm today, invited by our postdocs. If you're local this is not to be missed!
