Kristoffer H. Johansen

Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells https://www.biorxiv.org/content/10.1101/2025.11.01.686037v1

Thanks for a lovely time in Cambridge - great to see you all again. Already looking forward to next time.

Our paper is now out with peer review!

This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved.

Read about it below in Tims breakdown!

A functionally validated TCR-pMHC database for TCR specificity model development Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...

It's not the models, it's the data!

We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.

www.biorxiv.org/content/10.1...