Kerry Hilligan

Kudos to Kit Moloney-Geany who generated the beautiful TLS images that brought the paper together! 🔬

Thanks to the rest of the team @malaghan.bsky.social and to Andrew Lim and the Cytek team for all their help and support 🙏

A HUGE shout out to PhD student, @rsjpalmer.bsky.social who lead this work (imaginatively called the Epic Lung Phenotyping Project) and flow gurus @katepilki.bsky.social and Kathryn Hally whose expertise was invaluable in getting the most high quality data possible.

Spatially Resolved Immune Profiling of the Murine Lung Using In Vivo Labeling and Spectral Cytometry The lung is a structurally and immunologically complex organ, constantly exposed to airborne microbes, allergens, and pollutants. Understanding how diverse pulmonary immune cells respond to these cha....

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Spatially Resolved Immune Profiling of the Murine Lung Using In Vivo Labeling and Spectral Cytometry The lung is a structurally and immunologically complex organ, constantly exposed to airborne microbes, allergens, and pollutants. Understanding how diverse pulmonary immune cells respond to these cha....

Calling all lung immunology enthusiasts 🫁

I’m excited to share this project where we designed and optimised a spectral cytometry platform to study immune responses in the mouse lung at steady-state and during viral infection. We hope this will be a useful resource for the field!

Link below 👇

Now up in the Thursday Plenary @kerryhilligan.bsky.social the #ASI2025 the Peter Doherty medal recipient, celebrating research excellence by ECRs

Congratulations to @kerryhilligan.bsky.social for her Doherty Lectureship for her most excellent body of work studying tissue immunity to infections. #ASI2025 #PerthASI

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...

@kerryhilligan.bsky.social et al @niaidnews.bsky.social review the evidence that both the mycobacterial-specific & off-target nonspecific effects of BCG immunization require the interplay of innate & adaptive responses, the elucidation of which could improve #TB vaccines rupress.org/jem/article/...

Could you add me please 🙏

Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...

Lungs primed by past infections, like enriched soil, resist COVID-19 better, revealing why outcomes vary.

@mayerbarber.bsky.social @pauljbaker.bsky.social @kerryhilligan.bsky.social @danbarberphd.bsky.social @niaidnews.bsky.social @sciimmunology.bsky.social

t.co/5L7vmTbsNN
#ImmunoSky 🧪

Had a great time presenting my poster at ASI2024 Sydney Australia! We’re studying how the lung’s cellular landscape shifts during infection and influences future infections, using high-dimensional flow cytometry to profile and characterise pulmonary cells at steady state and during infection! 🫁

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.

Super privileged to have been apart of this amazing tour-de-force study from @pauljbaker.bsky.social, @mayerbarber.bsky.social and team showing how inflammatory history of the 🫁 alters susceptibility to #covid19.
Congrats team!! 🎉🎉

Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4 leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social @mayerbarber.bsky.social

Resharing this for those new to bluesky. If you are interested in #innateimmunity or #inflammation, here’s a starter pack or researchers to follow! Leave a comment if you wanna be added too. #immunosky #academicchatter
go.bsky.app/QqJ9AgB

A starter pack for PhD students and Postdocs in Immunology to connect 🔽

Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!

#ImmunoSky 🧪

go.bsky.app/RABVXY4

go.bsky.app/7zMmwNY

Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍

Could you add me too please 😀

I’ll take this opportunity to announce that I’ll have multiple postdoc positions opening early next year.

Come join us in Melbourne! 🇦🇺🐨🦘
If you’re interested in mucosal immunology, microbiology, parasitology, vaccine design or bioinformatics, get in touch ✉️!
#ImmunoSky #MicroSky #IDSky

Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates
www.pnas.org/doi/epub/10.... @pnas.org

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

The measles vaccine is given as a shot but it is surprisingly good at inducing protective immunity in the respiratory tract (mucosal IgA). Our new study provides some clues about why...a thread (1/8) #IDSky #MedSky #lungs #immunology #ImmunoSky academic.oup.com/jid/advance-...

Hi Bluesky! 👋
Dipping my toes here given the dumpsterfire over at X. I am Editor in Chief of #PLOSBiology, interested in all things #science.
#virologist, passionate about #OpenScience & making #publication process constructive & transparent.
I look forward to rebuilding community here!

we love #tcell #immunology but are steadily starting to swoon in the world of lung #macrophages. is no marker sacred? 😂

Ly6G+ macrophages? CD64+ #neutrophils?

pubmed.ncbi.nlm.nih.gov/39093958/
pubmed.ncbi.nlm.nih.gov/38844208/

Please add me too 😃

👋 fellow immunologists, it’s a pleasure to be with you all on bsky! I work on type I #interferons, I figured it would be neat to have a starter pack for those of us working on all things IFN! I’ll keep adding to it, let me know if you want to be included! #immunology #immunosky go.bsky.app/71vKZJA

🦋 We're in the process of moving here from X. Join us, follow & share your research & publications (cytokine related or outside the boundaries, published or pre-pub), job openings, meetings & informal gatherings where great ideas are born & cultivated @cytokinesociety.bsky.social