Ale Santuz

See you in Kobe!

⏰ Postdoc position deadline approaching!
📅 Apply by 30 November 2025!

If you’ve ever attempted a meta-analysis, you’ll know that authors generally do a poor job reporting statistics. If you do this well, you’ll improve your chances of your work being included in a future meta-analysis.

🔬 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗼𝗽𝗲𝗻𝗶𝗻𝗴!

I’m recruiting a postdoctoral researcher (@mdc-berlin.bsky.social, Berlin 🇩🇪, @niccolozampieri.bsky.social lab) for my @dfg.de -funded project on somatosensory feedback and locomotor control. Please repost and DM me if interested!

#locomotion #proprioception #neuromechanics

📅 Tue 4 Nov 2025, 10.00 am CET 🎙️ Speaker: James Bryson, Biotech Research & Innovation Centre (BRIC), University of Copenhagen 🫴 Host: Eva Maria Novoa, Centre for Genomic Regulation (CRG) 🏛️ Venue: AULA Room 473.10 at hashtag#CRG and online 💡 Title: 𝗘𝘅𝘁𝗲𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝘁𝗼𝗼𝗹𝘀 𝗳𝗼𝗿 𝗴𝗲𝗻𝗲 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗲𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗲𝗽𝗶𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰 𝘁𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 🔍 Abstract: The toolbox for gene expression regulation has expanded far beyond Cas9. New generations of CRISPR variants, including Cas12 and Cas13, enable robust and multiplexed control of gene expression. In this seminar, James Bryson will present novel CRISPR-based tools and a computational approach for crRNA design, as well as explore how small nucleolar RNAs and epitranscriptomic interactions influence translational regulation and cell fate.

🧬 𝗝𝗼𝗶𝗻 𝗼𝘂𝗿 𝗻𝗲𝘅𝘁 𝗘𝗨-𝗟𝗜𝗙𝗘 𝗣𝗼𝘀𝘁𝗱𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗘𝘅𝗰𝗵𝗮𝗻𝗴𝗲 𝗦𝗲𝗺𝗶𝗻𝗮𝗿!

All 𝘀𝘁𝗮𝗳𝗳 𝗺𝗲𝗺𝗯𝗲𝗿𝘀 𝗳𝗿𝗼𝗺 𝗘𝗨-𝗟𝗜𝗙𝗘 𝗶𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲𝘀 are invited to the hybrid seminar "𝗘𝘅𝘁𝗲𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝘁𝗼𝗼𝗹𝘀 𝗳𝗼𝗿 𝗴𝗲𝗻𝗲 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗲𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗲𝗽𝗶𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰 𝘁𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻", with James Bryson, @bric-ucph.bsky.social

🔬 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗼𝗽𝗲𝗻𝗶𝗻𝗴!

I’m recruiting a postdoctoral researcher (@mdc-berlin.bsky.social, Berlin 🇩🇪, @niccolozampieri.bsky.social lab) for my @dfg.de -funded project on somatosensory feedback and locomotor control. Please repost and DM me if interested!

#locomotion #proprioception #neuromechanics

On November 2nd with @alesantuz.bsky.social we will participate to Family Sunday at Deutsches Hygiene-Museum in Dresden to talk to chidlren and their families about proprioception. Looking forward to it 💥

A spinal circuit for skilled locomotion Toscano et al. identify glutamatergic Pitx2+ V0 ascending neurons (V0g-aNs) that receive input from cerebrospinal fluid (CSF)-contacting neurons and target spinal premotor and motor neurons. Eliminati...

I really like this one 🤓. Work led by Elisa Toscano with invaluable help from many 🙏 @alesantuz.bsky.social, @lowensteined.bsky.social. A spinal circuit for skilled locomotion www.cell.com/current-biol...

Evidence of spinal cord comparator modules for rapid corrections of movements Successful movement requires continuous adjustments in response to changes in internal and external environments. To do so, neural circuits continuously compare efference copies of motor commands with sensory input to respond to sensory prediction errors. Some responses need to be very fast and, for limbs, likely occur in as yet undefined spinal cord circuits. Here, we describe spinal circuits involving dI3 neurons, showing that they receive multimodal sensory inputs and direct efferent copies from both Renshaw cells and motor neurons. We further show that they form connections to motor pools, including diverging connections to antagonist motor nuclei. Reducing dI3 neuronal activity diminished stumbling responses, as did disrupting Renshaw cell circuits, providing evidence for a comparator role of dI3 neurons for online corrections. Together, our findings reveal a pivotal role for dI3 neurons functioning as comparators of internal predictions and external sensory feedback to mediate rapid corrections of ongoing movements. ### Competing Interest Statement Robert M. Brownstone is a co-founder and director of Sania Therapeutics Inc. Wellcome Trust, https://ror.org/029chgv08, 221610/Z/20/Z, 227433/Z/23/Z, 225674/Z/22/Z Royal Society, NIF\R1\192316 Canadian Institutes of Health Research, https://ror.org/01gavpb45, PJT 180556, PJT 162357 Biotechnology and Biological Sciences Research Council, BB/S005943/1

Do comparator modules exist within spinal circuits? Here, we show that spinal dI3 neurons integrate multimodal sensory feedback, receive direct efference copy from Renshaw cells, and mediate corrections of ongoing movements. Thank you so much to everyone involved!!
www.biorxiv.org/content/10.1...

#musclesyneRgies 1.2.5.9009 (development version)

How to install
𝚒𝚗𝚜𝚝𝚊𝚕𝚕.𝚙𝚊𝚌𝚔𝚊𝚐𝚎𝚜("𝚛𝚎𝚖𝚘𝚝𝚎𝚜")
𝚛𝚎𝚖𝚘𝚝𝚎𝚜::𝚒𝚗𝚜𝚝𝚊𝚕𝚕_𝚐𝚒𝚝𝚑𝚞𝚋("𝚊𝚕𝚎𝚜𝚊𝚗𝚝𝚞𝚣/𝚖𝚞𝚜𝚌𝚕𝚎𝚜𝚢𝚗𝚎𝚁𝚐𝚒𝚎𝚜")

Improved function CoA with non-duplicated angles and robust quadrant handling. Please update!

#rstats #opensource

github.com/alesantuz/mu...

Should I publish in @joss-openjournals.bsky.social? I found it to be exactly the right place to publish @musclesynergies.bsky.social. Because the review is a) an actual review of the software and b) an efficient, interactive process. I loved it!

www.fz-juelich.de/en/rse/the_l...

New job vacancy!

Joint PhD: Prevent Falls with Augmented Reality (FallAR) at Maastricht & Hasselt Universities
vacancies.maastrichtuniversity.nl/job/Maastric...
with me, @melvynroerdink.bsky.social Pieter Meyns & @kennethmeijer.bsky.social

@ispgr.bsky.social @worldfallssociety.bsky.social

The CEDE website is now up and running. Designing an experiment using EMG? Then check out this website and try the decision support tool:
cede.isek.org

Stockholm bound for #isb2025! Come and say hi on Tuesday (poster on loss of #proprioception) or Wednesday (talk on #locomotor modularity in simulated #hypogravity)!
#musclesyneRgies #neuroscience #biomechanics #locomotion @mdc-berlin.bsky.social

I'm putting together a starter pack of neuro people working on #proprioception. Reply or DM to be added!
go.bsky.app/RXN6MB2

Stockholm bound for #isb2025! Come and say hi on Tuesday (poster on loss of #proprioception) or Wednesday (talk on #locomotor modularity in simulated #hypogravity)!
#musclesyneRgies #neuroscience #biomechanics #locomotion @mdc-berlin.bsky.social

Are you interested in muscle #biomechanics and looking for #postdoc opportunities?

If you have skills in (statistical) shape modelling, advanced data analyses or 3D imaging/model reconstructions, get in touch with me!

I will be at #SEB2025 (Antwerp), #CNB2025 (Helsinki), and #ISB2025 (Stockholm).

What is common knowledge in your field, but shocks outsiders?

Unless you seek it out, most professors don't learn how to teach. It's not part of the job requirements. The idea is that you're an expert in your field and that's Enough.

Max wanted a bit of a provocative talk tomorrow. So I will talk about which open science should become mandatory. For example, science funders now often require open access publication and data sharing. Which open science practices do you think should become mandatory, and under which circumstances?

Better artificial intelligence does not mean better models of biology Deep neural networks (DNNs) once showed increasing alignment with primate perception and neural responses as they improved on vision benchmarks, raising hopes that advances in AI would yield better mo...

Read the full preprint here: arxiv.org/abs/2504.16940

different coloured mice on a white background

Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx

If you're in Berlin and working in #neuroscience, join us on 4 April @mdc-berlin.bsky.social for the 2025 MDC Neuroscience Meeting! There will be talks by our PhD students and postdocs (including yours truly with a talk on #locomotion and #proprioception), followed by a social poster session.

If you're in Berlin and working in #neuroscience, join us on 4 April @mdc-berlin.bsky.social for the 2025 MDC Neuroscience Meeting! There will be talks by our PhD students and postdocs (including yours truly with a talk on #locomotion and #proprioception), followed by a social poster session.

EU-LIFE Postdoctoral Exchange Programme. Applications open!

🎓🔬🚀 Do you want to boost your academic career? Would you like to present your work to leading researchers and build a professional network across Europe?

If you are an EU-LIFE #postdoc, this is your chance! The EU-LIFE Postdoctoral Exchange Programme is open for applications ➡️ bit.ly/3WgNek3

Identification of V0g propriospinal neurons and their role in locomotor control Propriospinal neurons relay sensory and motor information across the spinal cord and are critical components of the circuits coordinating body movements. Their diversity and roles in motor control are...

🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸‍♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think:
www.biorxiv.org/content/10.1...

Come to Amsterdam this fall (Oct 8-10) for the International Motor Impairment Conference!

The #EULIFE Postdoctoral Exchange Programme is up! eu-life.eu/postdoc-exch...

Identification of V0g propriospinal neurons and their role in locomotor control https://www.biorxiv.org/content/10.1101/2025.02.11.636221v1

Identification of V0g propriospinal neurons and their role in locomotor control https://www.biorxiv.org/content/10.1101/2025.02.11.636221v1

The #EULIFE Postdoctoral Exchange Programme is up! eu-life.eu/postdoc-exch...