Kyle Jarrod McLean's Avatar

Kyle Jarrod McLean

@kylejarrodmclean

Malaria parasites, synthetic biology & tool development. @ MIT

443
Followers
884
Following
2
Posts
09.02.2024
Joined
Posts Following

Latest posts by Kyle Jarrod McLean @kylejarrodmclean

Preview
A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito Author summary Malaria parasites complete their life-cycle within mammalian and mosquito hosts requiring specialised forms to invade and establish infection in host tissue. In order to transmit to the...

Delighted to report our publication on a divergent cyclic nucleotide binding protein that regulates malaria transmission to mosquitoes. Great work by Domi Kwecka , @jennyregan.bsky.social @choel Kim #malaria #ookinete #mosquitoes #signalling journals.plos.org/plospathogen...

16.09.2025 09:33 πŸ‘ 24 πŸ” 5 πŸ’¬ 1 πŸ“Œ 2

This is actually my specialty. We've got an array of tricks and tools for working with DNA sequences that E. coli hates. Happy to discuss more.

03.09.2025 13:41 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

In America, they have a Mason-Dixon Line. In Canada, it’s the Swiss Chalet-St-Hubert Line.

01.09.2025 14:07 πŸ‘ 17 πŸ” 3 πŸ’¬ 3 πŸ“Œ 0
Preview
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.comπŸ₯³ rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

18.08.2025 12:13 πŸ‘ 87 πŸ” 38 πŸ’¬ 4 πŸ“Œ 2
Preview
Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti Nature Communications - Infection of mosquito immune cells by dengue and Zika virus enhances the spread of virus infection to mosquito tissues, such as the salivary glands, to promote virus...

Excited to share our latest collaborative work with @entomososwin.bsky.social @brackneylab.bsky.social looking at the role of mosquito immune cells in virus infection. It turns out that these cells help disseminate virus infection, increasing the potential for virus transmission rdcu.be/euiZt

03.07.2025 12:33 πŸ‘ 38 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1
Preview
An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention. Like the mitochondrion, th...

🚨 New preprint alert! 🚨
We’ve uncovered a key player in malaria parasite cell divisionβ€”meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧡for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...

14.04.2025 19:45 πŸ‘ 45 πŸ” 16 πŸ’¬ 2 πŸ“Œ 0

They use the term "Entitlements" as a pejorative. It it not.

Things like Social Security are called Entitlements because... you're ENTITLED to them. You paid in. You're entitled to get paid out.

Tax breaks for billionaires are NOT entitlements.

10.03.2025 21:45 πŸ‘ 20 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

Ever run your plasmids through plannotate.barricklab.org ? Those blank spaces often hold the ghosts of projects passed. I've discovered unannotated strong bacterial promoters pointing right at my potentially toxic ORFs.

16.02.2025 18:40 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Iron-mediated post-transcriptional regulation in Toxoplasma gondii Author summary Although iron is essential for most cells, excess can be toxic, so uptake and storage must be carefully controlled. The ability to respond to iron is particularly important for parasite...

Excited to be able to share our new paper 'Iron Mediated Post-Transcriptional Regulation in Toxoplasma gondii'! Thanks to all involved including the awesome @clarehardinglab.bsky.social and @danaaghabi.bsky.social! journals.plos.org/plospathogen.... Read on for quick-read digest of our new work...

05.02.2025 11:50 πŸ‘ 27 πŸ” 8 πŸ’¬ 4 πŸ“Œ 2

Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful

14.01.2025 22:30 πŸ‘ 746 πŸ” 166 πŸ’¬ 14 πŸ“Œ 9

There is no justification for a higher bar of fees/taxes/anti-gentrification policy for apartments. Low density is the most gentrifying build environment in a city, lived in by the richest. Higher density is what lower income and less wealthy people live in.

14.01.2025 21:54 πŸ‘ 12 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

I just read another paper that didn’t deposit their plasmid sequences anywhere. It doesn’t have to be Addgene, but gbk file on Zenodo would be good. I literally have no way to find out the exact modifications to the constructs from the text. Journals shouldn’t allow this.

24.05.2024 03:34 πŸ‘ 14 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0
Preview
Malaria Is Surging in Ethiopia, Reversing a Decade of Progress Against the Disease Climate change, civil conflict and growing resistance to insecticides and treatments are all contributing to an alarming spread of cases.

🌍" #Malaria Is Surging in #EthiopiaπŸ‡ͺπŸ‡Ή, Reversing Decade of Progress Against the Disease.
#ClimateChange, civil conflict and growing #resistance to insecticides & treatments [+spread of An. stephensi🦟] are all contributing to alarming spread of cases." @nytimes.com
www.nytimes.com/2024/10/25/h...

25.10.2024 11:14 πŸ‘ 4 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

New version of this paper just hit @biorxivpreprint! New collaborator co-authors, and their very interesting new data on vertebrate DNA detection in wild-caught male mosquitoes! Perhaps this is not just a crazy lab phenomenon after all!

www.biorxiv.org/content/10.1...

25.10.2024 11:33 πŸ‘ 15 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0