🚀 Course: Advanced Python for Data Science & Bioinformatics
📅 23–26 March | 🌍 Online
Ready to level up your Python skills for biology? Dive into data wrangling, BioPython, visualization & machine learning, and build an end-to-end project 🐍📊🧬
www.physalia-courses.org/courses-work...
#Python
A minimal PyTorch re-implementation of AlphaFold2
github.com/ChrisHayduk/...
We need more stuff like this. The incentive is to always be making the new groundbreaking tool, while maintenance + improvement of "old" tools gets left behind. But there is still heaps to be gained in "old" tools
The Vatican Museums' Bramante Staircase provides a striking visual metaphor for a vicious feedback cycle in scholarly publishing: rising paper submissions across an expanding landscape of journals strains the limited supply of volunteer peer review labor, which in turn makes editorial decisions less predictable and encourages authors to submit their work more ambitiously, increasing the burden on peer reviewers further still. Image credit: Carl T. Bergstrom
The process of #PeerReview is vital to contemporary science, but is also under enormous strain. @carlbergstrom.com & Kevin Gross use mathematical models to dissect the threats to the long-term viability of peer review, suggesting ways to stabilize it @plosbiology.org 🧪 plos.io/4kR02bo
As scRNA-seq cohorts grow in scale (e.g. FinnGen, TenK10K), so does the need for methods that can handle millions of cells from thousands of donors. LIVI's scalable design enables systematic trans-eQTL discovery in such datasets, revealing cellular mechanisms underlying complex disease risk. 11/n
Working on trans-eQTL mapping with population-scale scRNA-seq? Meet LIVI, our latest framework that enables efficient trans-eQTL mapping at single-cell resolution across cohorts of hundreds to thousands of donors.
Preprint: doi.org/10.64898/202...
Summary in the 🧵 below by @danaivagiaki.bsky.social
Allele-specific splicing modulates protein isoforms and Alzheimer's risk https://www.biorxiv.org/content/10.64898/2026.02.13.705796v1
📝 Researchers identify potential immune evasion mechanism in premalignant lung lesions
✍️ RNA-Seq Blog
📝 Nanopore sequencing of intact aminoacylated tRNAs
✍️ RNA-Seq Blog
A child drawing of a female scientist. The hedline is: What does a scientist look like? Children are drawing women more than ever before
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #WomenInScienceDay: https://scim.ag/4qFrPON
A LaTeX package to add coffee strains to your documents😆
framagit.org/Pathe/coffee...
Biological data governance in an age of AI www.science.org/doi/10.1126/... #biosecurity
the Epstein files are really devastating because they remind me of how many girls and women miss out on professional opportunities, mentorship and careers because of how many powerful, rich and influential men only view girls and women — and interactions with them — through the lens of sex
"Both research papers and salami can be cut into multiple, smaller pieces."
Insightful.
en.wikipedia.org/wiki/Least_p...
I am first in line for Eppendorf Bingo Daubers. Please,
@eppendorf.bsky.social
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
A Most Powerful Test for Gene-Gene Interaction in the Presence of Main Effects https://www.biorxiv.org/content/10.64898/2026.01.30.702572v1
Google with AI buttons
Google without AI buttons
I made a filterlist for uBlock Origin to remove Generative AI features on websites. Includes blocks for
* Google AI Summaries
* YouTube Ask button & chat summaries
* GitHub Copilot
* Facebook AI chat
* X's Grok buttons
* Deviantart DreamUp
* Booru AI images
* And more
github.com/Stevoisiak/S...
Person: say, i am alive. Computer: I am alive. Person: oh my god.
I agree, very interesting! Research by Marignani Lab team @pmarignani.bsky.social 💡
A reminder that proteins are highly dynamic molecules.
🟧 We have made much progress in measuring & predicting static protein structures, but the dynamics that animate life remain challenging to measure & model.
Guide to multi-omics integration with toy examples: supervised latent components (DIABLO), unsupervised shared/partial/unique structure (DIVAS), VAEs/conditional VAEs, and key baselines (MOFA, JIVE, SNF) with practical tips + code. github.com/Trhova/Multi...
Advancing regulatory variant effect prediction with AlphaGenome www.nature.com/articles/s41... 🧬💻🧪
Code: github.com/google-deepm...
Author roundtable: www.youtube.com/watch?v=V8lh...
This preprint combines cell-line scRNA-seq reanalysis with bulk LUAD checks in cBioPortal. The cross-dataset consistency for metabolic and cell cycle terms is encouraging.
🚨 Alarm!!! 🚨
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?
20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026
✍️ Jan 15 2026 ✍️
🔁 pls!!
www.janelia.org/you-janelia/...
microcentrifuge tube racks with Rack names
I was lucky enough to inherit a bunch of racks where a graduate student had labelled all of them with Rack jokes 😂, perfect. I am dead at Racksputin.
Most of what makes cells functionally distinct happens at the post-transcriptional level, but we spent a decade obsessing over transcriptomics.
scRNAseq is powerful precisely because it's incomplete.
It forces us to think about what it doesn't capture.
Great work by Hengxin Pan presenting at #abacbs2025 from @nadia-davidson.bsky.social lab @wehi-research.bsky.social CONCERTDR: an R package with a comprehensive suite of tools for drug response data analysis
github.com/DavidsonGrou...
Nature research paper: Semantic design of functional de novo genes from a genomic language model
go.nature.com/48uEnAn
